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Recombinant Human Tumor Susceptibility Gene 101, His-tagged

Cat. No. : TSG101-2357H
Product Overview : Recombinant human TSG101 protein, fused to His-tag at N-terminus, was expressed inE.coliand purified by using conventional chromatography techniques. 20.7 kDa (181aa).
Description : TSG101(Tumor susceptibility gene 101) protein belongs to a group of apparently inactive homologs of ubiquitin-conjugating enzymes. This protein contains a coiled-coil domain that interacts with stathmin, a cytosolic phosphoprotein implicated in tumorigenesis. Mutations and alternative splicing in this protein occur in high frequency in breast cancer and suggest that defects occur during breast cancer tumorigenesis and/or progression.
Source : E.coli.
Form : Liquid. In 20 mM Tris-HCl buffer (pH8.0) containing 1mM DTT, 10% glycerol.
Purity : > 90% by SDS - PAGE.
Concentration : 0.5 mg/ml (determined by Bradford assay).
Sequences Of Amino Acids : MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMAVS ESQLKKMVSK YKYRDLTVRE TVNVITLYKD LKPVLDSYVF NDGSSRELMNLTGTIPVPYR GNTY NIPICL WLLDTYPYNP PICFVKPTSS MTIKTGKHVD ANGKIYLPYL HEWKHPQSDL LGLIQVMIVV FGDEPPVFSRP.
Storage : Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Gene Name : TSG101 tumor susceptibility gene 101 [ Homo sapiens ]
Synonyms : tumor susceptibility gene 101; TSG10; VPS23; TSG101; tumor susceptibility gene 101 protein; tumor susceptibility protein; ESCRT-I complex subunit TSG101; tumor susceptibility gene 10; tumor susceptibility protein
Gene ID : 7251
mRNA Refseq : NM_006292
Protein Refseq : NP_006283
MIM : 601387
UniProt ID : Q99816
Chromosome Location : 11p15
Pathway : Endocytosis
Function : ligand-dependent nuclear receptor transcription coactivator activity; DNA binding; calcium-dependent protein binding; protein binding; small conjugating protein ligase activity; transcription corepressor activity; ubiquitin binding

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