"PDK3" Related Products

Recombinant Human PDK3, His-tagged

Cat. No.: PDK3-652H
Product Overview: Recombinant Human PDK3 with a His tag is expressed inBacteriaand column-purified.
Description: PDH kinases (PDK"s) deactivate PDH by reversible phosphorylation. In humans and rodents, 4 PDK"s are present in an organ-dependent manner. In all cases, PDK"s are physically part of the PDH complex (binding via lipoyl domain 2 of E2), and they phosphorylate the E1 subunit at 3 specific serine residues. PDH phosphatases remove the phosphorylation and restore activity of PDH.
Source: Bacteria.
Storage: Store at -80°C.
Gene Name: PDK3 pyruvate dehydrogenase kinase, isozyme 3 [ Homo sapiens ]
Synonyms: PDK3; pyruvate dehydrogenase kinase, isozyme 3; [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3, mitochondrial; pyruvate dehydrogenase kinase, isoenzyme 3; pyruvate dehydrogenase, lipoamide, kinase isozyme 3, mitochondrial; EC 2.7.11.2
Gene ID: 5165
mRNA Refseq: NM_001142386
Protein Refseq: NP_001135858
MIM: 602526
UniProt ID: Q15120
Chromosome Location: Xp22.11
Pathway: Integration of energy metabolism; Pyruvate metabolism and Citric Acid (TCA) cycle
Function: ATP binding; nucleotide binding; protein heterodimerization activity; pyruvate dehydrogenase (acetyl-transferring) kinase activity; protein homodimerization activity; transferase activity; two-component sensor activity

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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