PDK1
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Official Full Name
pyruvate dehydrogenase kinase, isozyme 1
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Overview
Phosphoinositide-dependent protein kinase 1 (PDK-1) plays a central role in many signal transduction pathways, activating AKT and the PKC isoenzyme p70S6 kinase and RSK. Through its effects on these kinases, PDK-1 is involved in the regulation of wide variety of process, including cell proliferation, differentiation and apoptosis. -
Synonyms
PDK1; pyruvate dehydrogenase kinase, isozyme 1; pyruvate dehydrogenase kinase, isoenzyme 1; mitochondrial pyruvate dehydrogenase, lipoamide, kinase isoenzyme 1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Assay Kits
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- Human
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- E.coli
- HEK293
- HEK293T
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- Mammalian cells
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- GST
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- Involved Pathway
- Protein Function
- Interacting Protein
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- PDK1 Related Signal Pathway
PDK1 involved in several pathways and played different roles in them. We selected most pathways PDK1 participated on our site, such as HIF- signaling pathway, Central carbon metabolism in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| HIF- signaling pathway | HKDC1;FLT1;HK1;HK3;CUL2;INSR;INS1;TCEB1;CAMK2G |
| Central carbon metabolism in cancer | RET;TP53;NRAS;SCO2;PIK3CD;PDK1;HK1;HK3;FGFR1 |
PDK1 has several biochemical functions, for example, ATP binding, protein binding, protein kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PDK1 itself. We selected most functions PDK1 had, and list some proteins which have the same functions with PDK1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | ACVR1BA;ADCY9;KIF12;DDX47;MYHC4;ABCC12;EHD4;DAK;EPHA4A |
| protein binding | WNT11;RBMS1;FBXO2;KANK2;PRH1;MYO7B;CD5;RAI1;SF3B2 |
| protein kinase activity | INSRB;MMD;CSF1RA;IGF1RB;ADRBK1;ERBB4A;MAPK14B;SMOK2B;STK30 |
| pyruvate dehydrogenase (acetyl-transferring) kinase activity | PDK2;PDK3;PDK4;PDK1 |
PDK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PDK1.
SGK3; PDHA1; RPS6KB1; PKN2; EPAS1; XRCC6; VWA8; CELF2; RIMS1; COG4; HMGN1; MYH1; COL4A5; PDK2
Research Area
Related articles
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Customer Reviews (3)
Write a reviewPDK1 production process is strictly controlled and the quality of the product is guaranteed.
Reproducibility of PDK1 is simply unrivaled, with identical results in every experiment or application, demonstrating its high stability and reliability.
The catalytic activity of PDK1 is excellent, which can simplify complex chemical reactions and improve yields, and its scientific research value is self-evident.
Q&As (6)
Ask a questionMay play a role in the occurrence of obesity, and the current research conclusions still need to be further verified.
PDK1 is thought to be associated with the occurrence and progression of cardiovascular disease, and may affect the health of the cardiovascular system by regulating the glucose metabolism of cardiomyocytes and the activity of phosphatase. However, further research and validation are needed.
Participates in a variety of signaling pathways, such as Akt and PKC, and affects the transmission and regulation of various signaling pathways by regulating the kinase activities of related receptors and enzymes.
PDK1 has abnormal expression in a variety of tumors, such as breast cancer, pancreatic cancer, colorectal cancer, etc., and is one of the important markers of tumor occurrence and prognosis.
The plays an important role in regulating cell metabolism and plays an important role in energy metabolism by regulating the phosphorylation state of various enzymes.
It has been identified as a potential therapeutic target for new diabetes, possibly by improving insulin signaling and glycogen synthesis, but further exploration is needed.
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