"RAP1A" Related Products

Recombinant Human RAP1A, His-tagged

Cat. No. : RAP1A-2584H
Product Overview : Recombinant human RAP1A, fused to His-tag at N-terminus, was expressed inE.coliand purified by using conventional chromatography.
Description : Ras-related protein Rap-1A (RAP1A) belongs to the family of RAS-related proteins. These proteins share approximately 50% amino acid identity with the classical RAS proteins and have numerous structural features in common. The most striking difference between RAP proteins and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. This Protein Induces morphological reversion of a cell line transformed by a Ras oncogene and Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner.
Source : E.coli.
Sequences : MGSSHHHHHH SSGLVPRGSH MREYKLVVLG SGGVGKSALT VQFVQGIFVE KYDPTIEDSY RKQVEVDCQQ CMLEILDTAG TEQFTAMRDL YMKNGQGFAL VYSITAQSTF NDLQDLREQI LRVKDTEDVP MILVGNKCDL EDERVVGKEQ GQNLARQWCN CAFLESSAKS KINVNEIFYD LVRQINRKTP VEKKKPKKKS C.
Molecular Weight : 22.8kDa (201aa) confirmed by MALDI-TOF.
Form : Liquid. 20mM Tris-HCl buffer (pH8.0) containing 40% glycerol, 5mM DTT, 200mM NaCl.
Purity : > 85% by SDS – PAGE.
Concentration : 0.25mg/ml (determined by Bradford assay).
Storage : Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Gene Name : RAP1A RAP1A, member of RAS oncogene family [ Homo sapiens ]
Synonyms :
RAP1A; RAP1A, member of RAS oncogene family; C21KG; G-22K; GTP-binding protein smg p21A; OTTHUMP00000013742; RAS-related protein RAP1A; Ras-related protein Krev-1; ras-related protein Rap-1A; KREV-1; KREV1; RAP1; SMGP21
Gene ID : 5906
mRNA Refseq : NM_001010935
Protein Refseq : NP_001010935
MIM : 179520
UniProt ID : P62834
Chromosome Location : 1p13.3
Pathway : Chemokine signaling pathway; Focal adhesion; Leukocyte transendothelial migration; Neurotrophin signaling pathway; Diabetes pathways; Integration of energy metabolism; Integrin cell surface interactions; Signalling by NGF
Function : GTP binding; GTPase activity; Ras GTPase binding; nucleotide binding; protein binding

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