• Official Full Name

    RAP1A, member of RAS oncogene family

  • Overview

    The product of this gene belongs to the family of RAS-related proteins. These proteins share approximately 50% amino acid identity with the classical RAS proteins and have numerous structural features in common. The most striking difference between RAP proteins and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. The product of this gene counteracts the mitogenic function of RAS because it can interact with RAS GAPs and RAF in a competitive manner. Two transcript variants encoding the same protein have been identified for this gene.
  • Synonyms

    RAP1A; RAP1A, member of RAS oncogene family; ras-related protein Rap-1A; KREV 1; SMGP21; C21KG; G 22K; G-22K; GTP binding protein smg p21A; GTP-binding protein smg p21A; KREV1; OTTHUMP00000013741; RAP 1A; RAP1; RAP1A member of RAS oncogene family; RAP1A_HUMAN; Ras related protein Krev 1; Ras related protein Rap 1A; RAS related protein RAP1A; Ras-related protein Krev-1; OTTHUMP00000013740; RAS-related protein RAP1A; KREV-1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • MYC
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human RAP1A-118H Recombinant Human RAP1A, GST-tagged E.coli GST
Human RAP1A-2176H Recombinant Human RAP1A, His-tagged E.coli His 1-184aa
Human RAP1A-2584H Recombinant Human RAP1A, His-tagged E.coli His
Human RAP1A-30502TH Recombinant Human RAP1A, His-tagged E.coli His
Human RAP1A-2529HCL Recombinant Human RAP1A 293 Cell Lysate HEK293 N/A
Human RAP1A-2530HCL Recombinant Human RAP1A 293 Cell Lysate HEK293 N/A
Human RAP1A-6523H Recombinant Human RAP1A Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Mouse Rap1a-443M Recombinant Mouse Rap1a Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rat RAP1A-4923R Recombinant Rat RAP1A Protein Mammalian Cell His
Rat Rap1a-255R Recombinant Rat Rap1a E.coli N/A
Rat RAP1A-4582R Recombinant Rat RAP1A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat RAP1A-4582R-B Recombinant Rat RAP1A Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque RAP1A-3784R Recombinant Rhesus monkey RAP1A Protein, His-tagged Mammalian Cell His
Rhesus Macaque RAP1A-3601R-B Recombinant Rhesus Macaque RAP1A Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque RAP1A-3601R Recombinant Rhesus Macaque RAP1A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

RAP1A involved in several pathways and played different roles in them. We selected most pathways RAP1A participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RAP1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Ras signaling pathwayANGPT1;RGL2;FGF16;FGFR3;RAC2;PRKACB;GNG4;HRAS;PIK3R3
Rap signaling pathwayGNAS;ITGB2L;VASP;IGF1;Kitl;FYB;ITGAL;NGF;TLN1
Chemokine signaling pathwayMAPK3;GRK6;CXCR3;RELA;CXCL6;GRK5;CCL19;CCR6;BRAF
Leukocyte transendothelial migrationCLDN20;CYBB;CLDN4;ARHGAP5;VASP;MYL9;NIPAL1;CLDN18;VAV1
Long-term potentiationMAP2K1;EP300;PPP3CB;PLCB4;CAMK2B;CALM2;RPS6KA2;ARAF;RAP1B
Neurotrophin signaling pathwayMAPK13;ARHGDIG;NRAS;SHC3;PIK3R1;IRS1;CAMK2A;KRAS;MAPK11
Pancreatic secretionRAB8A;ATP1B1;PRKCA;TPCN2;PNLIP;PLCB2;ATP1A3;PRSS2;Cel
Renal cell carcinomaGAB1;RAP1A;NRAS;MET;PIK3CD;GRB2;RBX1;PTPN11;EGLN1

RAP1A has several biochemical functions, for example, GTP binding, GTPase activity, Rap guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RAP1A itself. We selected most functions RAP1A had, and list some proteins which have the same functions with RAP1A. You can find most of the proteins on our site.

Function Related Protein
Rap guanyl-nucleotide exchange factor activityRAPGEF5;RAPGEF3;RAP1A
protein complex bindingTULP3;ARRB2;FYB;KIF11;TWF1;NFYB;KRIT1;PPIB;ATF1
protein transporter activityVPS35;IPO8;TIMM10;AP1S3A;TMCO6;COG2;EIF4ENIF1;IPO4;CHMP7

RAP1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RAP1A here. Most of them are supplied by our site. Hope this information will be useful for your research of RAP1A.

RASSF5; RAF1; YWHAZ; RAPGEF2; FAS; VHL; Rassf5; RASGRP4; RASSF5; FTSJ1; TRAF6; Rabac1; GANAB; pi3p; gd3

Research Area

Related articles

Sayyah, J; Bartakova, A; et al. The Ras-related Protein, Rap1A, Mediates Thrombin-stimulated, Integrin-dependent Glioblastoma Cell Proliferation and Tumor Growth. JOURNAL OF BIOLOGICAL CHEMISTRY 289:17689-17698(2014).
Liu, LH; Aerbajinai, W; et al. Radil controls neutrophil adhesion and motility through beta 2-integrin activation. MOLECULAR BIOLOGY OF THE CELL 23:4751-4765(2012).
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