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RAP1GAP

Official Full Name

RAP1 GTPase activating protein
Overview

This gene encodes a type of GTPase-activating-protein (GAP) that down-regulates the activity of the ras-related RAP1 protein. RAP1 acts as a molecular switch by cycling between an inactive GDP-bound form and an active GTP-bound form. The product of this gene, RAP1GAP, promotes the hydrolysis of bound GTP and hence returns RAP1 to the inactive state whereas other proteins, guanine nucleotide exchange factors (GEFs), act as RAP1 activators by facilitating the conversion of RAP1 from the GDP- to the GTP-bound form. In general, ras subfamily proteins, such as RAP1, play key roles in receptor-linked signaling pathways that control cell growth and differentiation. RAP1 plays a role in diverse processes such as cell proliferation, adhesion, differentiation, and embryogenesis. Alternative splicing results in multiple transcript variants encoding distinct proteins.
Synonyms

RAP1GAP; RAP1 GTPase activating protein; RAP1, GTPase activating protein 1 , RAP1GA1; rap1 GTPase-activating protein 1; KIAA0474; RAP1GAP1; RAP1GAPII; Rap1 GTPase activating protein 1; RAP1GA1; Rap1ga1 protein; RAPGAP; OTTHUMP00000008709; OTTHUMP00000008710; OTTHUMP00000008711; OTTHUMP00000008712;

Type

Recombinant Proteins
Cell & Tissue Lysates

Species

Human
Mouse
Zebrafish

Source

E.coli
HEK293
HEK293T
Mammalian Cell

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	RAP1GAP-30503TH	Recombinant Human RAP1GAP, His-tagged	E.coli	His	Inquiry
Human	RAP1GAP-1129H	Recombinant Human RAP1 GTPase Activating Protein	E.coli	N/A	Inquiry
Human	RAP1GAP-2527HCL	Recombinant Human RAP1GAP 293 Cell Lysate	HEK293	N/A	Inquiry
Human	RAP1GAP-3334H	Recombinant Human RAP1GAP Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK	Inquiry
Mouse	Rap1gap-466M	Recombinant Mouse Rap1gap Protein, MYC/DDK-tagged	HEK293T	MYC/DDK	Inquiry
Zebrafish	RAP1GAP-6629Z	Recombinant Zebrafish RAP1GAP	Mammalian Cell	His	Inquiry

Involved Pathway
Protein Function
Interacting Protein

RAP1GAP involved in several pathways and played different roles in them. We selected most pathways RAP1GAP participated on our site, such as Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RAP1GAP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Rap signaling pathway	AKT2;BCAR1;LPAR2;PRKD2;CALML3;PDGFC;FLT4;GRIN1;F2R

RAP1GAP has several biochemical functions, for example, GTPase activator activity, GTPase activity, Ras GTPase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RAP1GAP itself. We selected most functions RAP1GAP had, and list some proteins which have the same functions with RAP1GAP. You can find most of the proteins on our site.

Function	Related Protein
GTPase activator activity	CDC42EP1B;RANGAP1A;ADAP1;CDC42EP3;SIPA1L2;ARFGAP3;ARHGEF15;ARHGAP8;ALDH1A1
GTPase activity	RAB10;TUBG1;GBP2;TUFM;GPN1;TUBB;IFT22;NKIRAS1;ARF1
Ras GTPase binding	CIB1;SPHK2;SH3BP4;RAP1GAP;PLCE1;MAPKAP1;RAP1A;RIN1;RASGRP3
protein binding	SPTBN1;DNTT;GGACT;CYHR1;KLRG1;GJA4;ORC2L;PRSS2;MBNL3
protein homodimerization activity	MYH9;DNM1L;IMPA2;MAP3K11;CHEK2;GDNFA;CHMP1A;CAMK2A;TGFB2

RAP1GAP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RAP1GAP here. Most of them are supplied by our site. Hope this information will be useful for your research of RAP1GAP.

RAP1B; Dlg4; YWHAZ; DYNC1I1; PFN2; CSNK1G2; MAPK6; MEX3B; MAP1LC3B