"PCBD1" Related Products

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Recombinant Human PCBD1, His-tagged

Cat. No.: PCBD1-2809H
Product Overview: Recombinant human PCBD1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. MW = 14.1 kDa (124aa), confirmed by MALDI-TOF.
Description: Pterin-4-alpha-carbinolamine dehydratase precursor, also known as PCBD1, is a component of the phenylalanine hydroxylase (PAH) system and participates in tetrahydrobiopterin biosynthesis. A deficiency of this enzyme leads to hyperphenylalaninemia. The enzyme regulates the homodimerization of the transcription factor hepatocyte nuclear factor 1 (HNF1).
Source: E.coli.
Sequences Of Amino Acids: MGSSHHHHHH SSGLVPRGSH MAGKAHRLSA EERDQLLPNL RAVGWNELEG RDAIFKQFHF KDFNRAFGFM TRVALQAEKL DHHPEWFNVY NKVHITLSTH ECAGLSERDI NLASFIEQVA VSMT
Purity: > 95% by SDS – PAGE.
Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 10% glycerol.
Concentration: 1 mg/ml (determined by Bradford assay).
Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Gene Name: PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha [ Homo sapiens ]
Synonyms: PCBD1; pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha; PCD; PHS; DCOH; PCBD; pterin-4-alpha-carbinolamine dehydratase; dimerizing cofactor for HNF1; dimerization cofactor of HNF1; 4-alpha-hydroxy-tetrahydropterin dehydratase; phenylalanine hydroxylase-stimulating protein; 6-pyruvoyl-tetrahydropterin synthase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1); EC 4.2.1.96; pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1); Pterin-4a-carbinolamine dehydratase (dimerization cofactor of hepatic nuclear factor 1-alpha); Pterin carbinolamine dehydratase; Dimerization cofactor of hepatocyte nuclear factor 1-alpha
Gene ID: 5092
mRNA Refseq: NM_000281
Protein Refseq: NP_000272
MIM: 126090
UniProt ID: P61457
Chromosome Location: 10q22
Pathway: Metabolism of amino acids and derivatives
Function: 4-alpha-hydroxytetrahydrobiopterin dehydratase activity; identical protein binding; lyase activity; phenylalanine 4-monooxygenase activity; protein binding; transcription coactivator activity

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