PCBD1
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Official Full Name
pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha
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Overview
This gene encodes pterin-4 alpha-carbinolamine dehydratase, an enzyme involved in phenylalanine hydroxylation. A deficiency of this enzyme leads to hyperphenylalaninemia. The enzyme regulates the homodimerization of the transcription factor hepatocyte nuclear factor 1 (HNF1). -
Synonyms
PCBD1; pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha; 6 pyruvoyl tetrahydropterin synthase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) , DCOH, PCBD, pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1); pterin-4-alpha-carbinolamine dehydratase; dimerizing cofactor for HNF1; PCD; pterin 4 alpha carbinolamine dehydratase; Pterin 4a carbinolamine dehydratase (dimerization cofactor of hepatic nuclear factor 1 alpha); 4 alpha hydroxy tetrahydropterin dehydratase; 4-alpha-hydroxy-tetrahydropterin dehydratase; 6 pyruvoyl tetrahydropterin synthase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1); 6 pyruvoyl tetrahydropterin synthase/dimerization cofactor of hepatocyte nuclear factor 1 alpha; DCoH; Dimerization cofactor of hepatic nuclear factor 1 alpha; Dimerization cofactor of hepatocyte nuclear factor 1 alpha; Dimerization cofactor of hepatocyte nuclear factor 1-alpha; Dimerization cofactor of HNF1; PCBD 1; PCBD; Phenylalanine hydroxylase stimulating protein; Phenylalanine hydroxylase-stimulating protein; PHS; PHS_HUMAN; Pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1); Pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha; Pterin carbinolamine dehydratase; OTTHUMP00000019765; 6-pyruvoyl-tetrahydropterin synthase/dimeriza;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- Yeast
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
PCBD1 involved in several pathways and played different roles in them. We selected most pathways PCBD1 participated on our site, such as Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism, Metabolism, Metabolism of amino acids and derivatives, which may be useful for your reference. Also, other proteins which involved in the same pathway with PCBD1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism | ACMSD;IDO2;SLC25A21;PCBD1;AFMID;UROC1;AMDHD1;FTCD;DLST |
| Metabolism | NDUFAF7;NDUFAF2;HAS1;FA2H;CPT2;GCHFR;SLC25A1A;CYP4F22;FABP11B |
| Metabolism of amino acids and derivatives | CKBA;AZIN1B;AFMID;IVD;SLC25A10;NAALAD2;SLC25A15;SLC6A8;ALDH9A1A.2 |
| Phenylalanine and tyrosine catabolism |
PCBD1 has several biochemical functions, for example, 4-alpha-hydroxytetrahydrobiopterin dehydratase activity, identical protein binding, phenylalanine 4-monooxygenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PCBD1 itself. We selected most functions PCBD1 had, and list some proteins which have the same functions with PCBD1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| 4-alpha-hydroxytetrahydrobiopterin dehydratase activity | PCBD2;PCBD1 |
| identical protein binding | GDF5;ACY3;DPP4;NME1;AIRE;TNN;CLDN9;KCNIP2;TPD52L1 |
| phenylalanine 4-monooxygenase activity | PAH;PCBD1;PCBD2 |
| protein binding | PDE3B;RPLP0;APOBEC3H;ITGB2;SHROOM2;TIMM8A;ZBTB7C;PDGFB;CA2 |
| transcription coactivator activity | RUNX1;KAT2A;ATF6;WNT3A;MED27;YAP1;VGLL1;SMARCC2;JUN |
PCBD1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PCBD1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PCBD1.
FXR2; LNX1; HNF1A; TFF3; APP; ACIN1
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