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Recombinant Rat Notch Homolog 2 (Drosophila) , Fc Chimera

Cat. No.: Notch2-2545R
Product Overview: Recombinant Rat Notch Homolog 2 produced inNSO cellswas expressed with Fc region of human.
Description: NOTCH2 is associated with Alagille syndrome.This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development.
Source: NSO cells.
Molecular Weight: Calculated mol wt 76.5 kDa; mol wt 105-115 kDa by SDS-PAGE (reducing).
Purity: ≥90% (SDS-PAGE).
Form: Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.
Analysis Note: The biological activity is measured by its ability to bind Jagged-1.
Storage: −20°C.
Gene Name: Notch2 Notch homolog 2 (Drosophila) [ Rattus norvegicus ]
Synonyms: Notch2; Notch homolog 2 (Drosophila); neurogenic locus notch homolog protein 2; notch 2; notch gene homolog 2
Gene ID: 29492
mRNA Refseq: NM_024358
Protein Refseq: NP_077334
UniProt ID: Q9QW30
Chromosome Location: 2q34
Pathway: Dorso-ventral axis formation; Notch signaling pathway
Function: calcium ion binding; protein binding; receptor activity

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