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Official Full Name notch 2
Background This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
Synonyms NOTCH2; notch 2; hN2; AGS2; HJCYS; neurogenic locus notch homolog protein 2; Notch homolog 2
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • CHO
    • E.coli
    • HEK293
    • Insect Cell
    • Mammalian Cell
    • NS0
    • Wheat Germ
    • Tag :
    • Fc
    • GST
    • His
    • His-Avi
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human NOTCH2-1814H Recombinant Human NOTCH2 protein, His-tagged E.coli His
    Human NOTCH2-29660TH Recombinant Human NOTCH2 Wheat Germ N/A
    Human NOTCH2-504H Recombinant Human NOTCH2 Protein, His-tagged Insect Cell His
    Human NOTCH2-5997H Recombinant Human NOTCH2 Protein, GST-tagged Wheat Germ GST
    Human NOTCH2-721H Recombinant Human NOTCH2 protein, Fc-tagged HEK293 Fc
    Human NOTCH2-721HB Recombinant Human NOTCH2 protein, His-Avi-tagged, Biotinylated HEK293 His-Avi
    Human NOTCH2-722H Recombinant Human NOTCH2 protein, His-Avi-tagged HEK293 His-Avi
    Mouse Notch2-436M Recombinant Mouse Notch2, Fc-tagged CHO Fc
    Mouse Notch2-650M Recombinant Mouse Notch2 Protein, Fc Chimera CHO Fc
    Rat Notch2-2545R Recombinant Rat Notch Homolog 2 (Drosophila) , Fc Chimera NS0 Fc
    Rat NOTCH2-4027R Recombinant Rat NOTCH2 Protein Mammalian Cell His
    Rhesus Macaque NOTCH2-3072R Recombinant Rhesus monkey NOTCH2 Protein, His-tagged Mammalian Cell His
    Chicken NOTCH2-4533C Recombinant Chicken NOTCH2 Mammalian Cell His
    Zebrafish NOTCH2-6534Z Recombinant Zebrafish NOTCH2 Mammalian Cell His

    notch2 involved in several pathways and played different roles in them. We selected most pathways notch2 participated on our site, such as Dorso-ventral axis formation, Notch signaling pathway, Thyroid hormone signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with notch2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Dorso-ventral axis formation PIWIL2; PPP1R2P9; ETS2; EGFRA; SPIRE1; PIWIL1; GRB2A; CPEB2; ETV6; ETV7
    Notch signaling pathway NOTCH1; LNX1; DLL4; LFNG; DTX3L; TLE3A; DVL1B; CNTN6; NOTCH1B; NOTCH4
    Thyroid hormone signaling pathway RXRB; PIK3R1; MED12L; SRC; PLCG1; EP300; PLCE1; GATA4; MAPK3; ESR1
    MicroRNAs in cancer PRKCG; MAPK1; MMP16; SIRT1; ABL1; EZR; IKBKB; GLS; HMGA2; CDC25C

    notch2 has several biochemical functions, for example, calcium ion binding, protein binding, receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by notch2 itself. We selected most functions notch2 had, and list some proteins which have the same functions with notch2. You can find most of the proteins on our site.

    Function Related Protein
    calcium ion binding ASPH; REPS1; PADI2; EFCAB2; PCDHB5; PCDH1GB9; CAPSLB; KCNIP3; EMR1; CA
    protein binding NCKAP1L; DKC1; PRKAA1; ITGA2B; RGS2; PIDD1; MEIS1B; MAGEA2B; CLK4; XPA
    receptor activity ADIPOR1A; NLGN1; CADM4; CD93; NR2C2; RAMP3; RTN4RL1; SLC20A2; Tnfrsf22; ANTXRL
    transcription factor activity, ligand-activated RNA polymerase II transcription factor binding NOTCH2

    notch2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with notch2 here. Most of them are supplied by our site. Hope this information will be useful for your research of notch2.

    ANKRD28; CRKL; IL24; IL13RA2; SMAD1; CST6; ysuR; ITIH5; EPSTI1; FAM84B; MTA3; PSMC3IP; KLK5; ST14; Bmpr1a; RBPJ; Lats2

    Huntzicker, EG; Hotzel, K; et al. Differential Effects of Targeting Notch Receptors in a Mouse Model of Liver Cancer. HEPATOLOGY 61:942-952(2015).
    Minuzzo, S; Agnusdei, V; et al. DLL4 regulates NOTCH signaling and growth of T acute lymphoblastic leukemia cells in NOD/SCID mice. CARCINOGENESIS 36:115-121(2015).

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