|Official Full Name||notch 3|
|Background||This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). [provided by RefSeq, Jul 2008]|
|Synonyms||NOTCH3; notch 3; IMF2; CASIL; CADASIL; neurogenic locus notch homolog protein 3; Notch homolog 3;|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
notch3 involved in several pathways and played different roles in them. We selected most pathways notch3 participated on our site, such as Dorso-ventral axis formation, Notch signaling pathway, Thyroid hormone signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with notch3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Dorso-ventral axis formation||SPIRE1; GRB2B; CPEB1B; NOTCH1B; MAP2K1; PIWIL1; SOS1; FMN2; PPP1R2P9; ETS1|
|Notch signaling pathway||RBPJL; JAG2B; CIR1; PTCRA; DLB; CNTN6; PSEN2; DLC; APH1C; DTX2|
|Thyroid hormone signaling pathway||PIK3CA; PIK3CB; NOTCH2; MED12L; PIK3R2; CASP9; MED4; PRKACG; SLC2A1; PRKACB|
|MicroRNAs in cancer||SOS1; TP53; CDCA5; CCND2; RECK; RAF1; CYP24A1; CDC25B; BRCA1; CDC25C|
notch3 has several biochemical functions, for example, calcium ion binding, enzyme binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by notch3 itself. We selected most functions notch3 had, and list some proteins which have the same functions with notch3. You can find most of the proteins on our site.
|calcium ion binding||CGREF1; CAPN2; PCDH1GB9; PCDH1G31; MFGE8B; MGMT; HEG; SDF4; EMR2; DSG4|
|enzyme binding||ECM1; PHKG2; HSPA2; NFKBIA; CBS; RYR2; MLL5; HIST1H2AM; NOP14; UGT1A9|
|protein binding||TUBB; IL17RE; CARTPT; ACVR2A; NEK6; EMP2; HEXIM1; TK1; AICDA; TJP1|
notch3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with notch3 here. Most of them are supplied by our site. Hope this information will be useful for your research of notch3.
Psma1; ABL1; NCK1; JAG1; LRP1; ANKRD28; FBLN1; CSNK2B; opuD; ald1; q8d176_yerpe; rhsA5; E2F3