| Description : |
This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
83 kDa |
| AA Sequence : |
MLPGLALLLLAAWTARALEVPTDGN AGLLAEPQIAMFCGRLNMHMNVQNG KWDSDPSGTKTCIDTKEGILQYCQE VYPELQITNVVEANQPVTIQNWCKR GRKQCKTHPHFVIPYRCLVGEFVSD ALLVPDKCKFLHQERMDVCETHLHW HTVAKETCSEKSTNLHDYGMLLPCG IDKFRGVEFVCCPLAEESDNVDSAD AEEDDSDVWWGGADTDYADGSEDKV VEVAEEEEVAEVEEEEADDDEDDED GDEVEEEAEEPYEEATERTTSIATT TTTTTESVEEVVREVCSEQAETGPC RAMISRWYFDVTEGKCAPFFYGGCG GNRNNFDTEEYCMAVCGSAIPTTAA STPDAVDKYLETPGDENEHAHFQKA KERLEAKHRERMSQVMREWEEAERQ AKNLPKADKKAVIQHFQEKVESLEQ EAANERQQLVETHMARVEAMLNDRR RLALENYITALQAVPPRPRHVFNML KKYVRAEQKDRQHTLKHFEHVRMVD PKKAAQIRSQVMTHLRVIYERMNQS LSLLYNVPAVAEEIQDEVDELLQKE QNYSDDVLANMISEPRISYGNDALM PSLTETKTTVELLPVNGEFSLDDLQ PWHSFGADSVPANTENEVEPVDARP AADRGLTTRPGSGLTNIKTEEISEV KMDAEFRHDSGYEVHHQKLVFFAED VGSNKGAIIGLMVGGVVIATVIVIT LVMLKKKQYTSIHHGVVEVDAAVTP EERHLSKMQQNGYENPTYKFFEQMQ NTRTRPLEQKLISEEDLAANDILDY KDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
