APP

  • Official Full Name

    amyloid beta (A4) precursor protein

  • Overview

    This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • Synonyms

    APP; amyloid beta (A4) precursor protein; AAA; AD1; PN2; ABPP; APPI; CVAP; ABETA; PN-II; CTFgamma; amyloid beta A4 protein; preA4; protease nexin-II; peptidase nexin-II; beta-amyloid peptide; alzheimer disease amyloid protein; cerebral vascular amyloid peptide;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Others
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Homo sapiens (Human)
  • Human
  • Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
  • Mouse
  • Mus musculus (Mouse)
  • Rat
  • Rattus norvegicus (Rat)
  • Sus scrofa (Pig)
  • Takifugu rubripes (Japanese pufferfish) (Fugu rubripes)
  • Tetraodon fluviatilis (Green pufferfish) (Chelonodon fluviatilis)
  • E. coli
  • E.coli
  • E.coli expression system
  • E.Coli or Yeast
  • HEK293
  • HEK293T
  • Human Cell
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Sf21 Insect Cell
  • Synthetic
  • Wheat Germ
  • C
  • Fc
  • hFc
  • His
  • GST
  • GST|His
  • His (Fc)
  • Avi
  • His|GST
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
  • SUMO
  • Tag Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human APP-526H Active Recombinant Human Amyloid Beta (A4) Precursor Protein, His-tagged Mammalian cells His
Human APP-192H Active Recombinant Human APP Protein, His/GST-tagged E.coli His/GST
Human APP-586H Active Recombinant Human APP protein(Met1-Leu669), hFc-tagged HEK293 C-hFc
Human APP-54H Active Recombinant Human APP/Protease Nexin II, CF Sf21 Insect Cell His
Human APP-6866H Recombinant Human Amyloid Beta(A4) Precursor Protein, GST-tagged and His-tagged E.coli GST/His
Human APP-191H Recombinant Human APP, His-GST tagged E.coli Fc
Human APP-243H Recombinant Human APP protein, MYC/DDK-tagged HEK293 Myc/DDK
Human APP-26791TH Recombinant Human APP protein(Asp672-Val710), His&GST-tagged E. coli N-His&GST
Human APP-3850H Recombinant Human APP, His & GST-tagged E.coli His/GST
Human APP-27315TH Recombinant Human APP E.coli N/A
Human APP-15839H Recombinant Human APP, His-tagged E.coli His
Human APP-244H Recombinant Human APP protein, MYC/DDK-tagged HEK293 Myc/DDK
Human APP-721H Recombinant Human APP protein, GST-tagged Wheat Germ GST
Human APP-3087HCL Recombinant Human APP cell lysate Human Cell N/A
Human APP-1191H Beta - Amyloid (1 - 40) N/A
Human APP-001H Human β-Amyloid (1-42) Synthetic N/A
Human APP-2877H Recombinant Human APP protein, His-tagged HEK293 His
Human APP-231H Recombinant Human APP Protein, His-tagged E.coli N-His
Human APP-62H Recombinant Human APP Protein, Fc-tagged Human Cell Fc
Human APP-5154H Recombinant Human APP Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human APP-0593H Recombinant Human APP Protein (Asp672-Val711), N-GST-tagged E.coli N-GST
Human APP-2746H Recombinant Human APP Protein, His&SUMO-tagged E.coli N-His&SUMO
Human APP-23H Active Recombinant Human APP Protein (18-701aa), C-His tagged HEK293 C-His
Human APP-1153HF Recombinant Full Length Human APP Protein, GST-tagged In Vitro Cell Free System GST
Human APP-3234H Recombinant Human APP protein(Asp672-Gly709), His&GST-tagged E. coli N-His&GST
Human APP-2488H-B Recombinant Human APP Protein Pre-coupled Magnetic Beads HEK293
Human APP-2878H Recombinant Human APP protein, His-tagged HEK293 His
Human APP-1290H Recombinant Human APP protein, His-tagged E.coli His
Human APP-1850H Recombinant Human APP protein, GST-tagged E.coli GST
Human APP-2876H Active Recombinant Human APP protein, His-tagged E.coli His
Human APP-2419H Recombinant Human APP Protein (Met1-Leu669), C-Fc tagged Mammalian cells C-Fc
Human APP-2488H Recombinant Human APP Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human APP-3646H Recombinant Human APP protein, His-tagged E.coli His
Human APP-4261H Recombinant Human APP Protein (Met1-Leu613), C-Fc tagged Mammalian cells C-Fc
Human APP-230H Recombinant Human APP Protein, His-tagged E.coli N-His
Human APP-0594H Recombinant Human APP Protein, Tag Free E.coli Tag Free
Mouse App-5746M Recombinant Mouse App protein, His-tagged E.coli His
Mouse APP-1812M Recombinant Mouse APP Protein Mammalian Cell His
Mouse App-3440M Recombinant Mouse App, His-tagged E.Coli or Yeast His
Mouse APP-643M Recombinant Mouse APP Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse APP-643M-B Recombinant Mouse APP Protein Pre-coupled Magnetic Beads HEK293
Mouse App-1666M Recombinant Mouse App Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat APP-731R Recombinant Rat APP Protein Mammalian Cell His
Rat APP-387R Recombinant Rat APP Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat APP-387R-B Recombinant Rat APP Protein Pre-coupled Magnetic Beads HEK293
Rat App-232R Recombinant Rat App Protein, His&GST-tagged E.coli N-His&GST
Homo sapiens (Human) RFL-31562HF Recombinant Full Length Human Amyloid-Beta Precursor Protein(App) Protein, His-Tagged E.coli expression system His
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) RFL-617MF Recombinant Full Length Macaca Fascicularis Amyloid Beta A4 Protein(App) Protein, His-Tagged E.coli expression system His
Mus musculus (Mouse) RFL-18930MF Recombinant Full Length Mouse Amyloid-Beta Precursor Protein(App) Protein, His-Tagged E.coli expression system His
Rattus norvegicus (Rat) RFL-10672RF Recombinant Full Length Rat Amyloid Beta A4 Protein(App) Protein, His-Tagged E.coli expression system His
Sus scrofa (Pig) RFL-30702SF Recombinant Full Length Pig Amyloid Beta A4 Protein(App) Protein, His-Tagged E.coli expression system His
Takifugu rubripes (Japanese pufferfish) (Fugu rubripes) RFL-31760TF Recombinant Full Length Takifugu Rubripes Amyloid Beta A4 Protein(App) Protein, His-Tagged E.coli expression system His
Tetraodon fluviatilis (Green pufferfish) (Chelonodon fluviatilis) RFL-14031TF Recombinant Full Length Tetraodon Fluviatilis Amyloid Beta A4 Protein(App) Protein, His-Tagged E.coli expression system His
Chicken APP-5881C Recombinant Chicken APP Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • APP Related Articles
  • APP Related Research Area
  • APP Related Signal Pathway

APP involved in several pathways and played different roles in them. We selected most pathways APP participated on our site, such as Serotonergic synapse, Alzheimers disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with APP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Serotonergic synapseHTR5A;GNG13;PLCB3;PRKCB;SLC6A4;GNAS;NRAS;KRAS;ALOX5
Alzheimers diseaseGAPDH;PPP3R1;Atp5g2;COX5B;NDUFS7;MME;NDUFA1;NDUFS5;NDUFV1

APP has several biochemical functions, for example, DNA binding, PTB domain binding, acetylcholine receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by APP itself. We selected most functions APP had, and list some proteins which have the same functions with APP. You can find most of the proteins on our site.

Function Related Protein
DNA bindingZFPM1;MB21D1;MSL3;YBX2;SPRTN;HOXB2A;GZF1;JUNB;PUF60
PTB domain bindingINSR;INPP5D;APP;NUP62
acetylcholine receptor bindingNRXN1;KCNS1;APP;DLG4;UBXN2A;RIC3;JAK2;RAPSN;RER1
enzyme bindingHSPA6;TNKS2;PRKCE;KAT8;TAL1;TOP2A;NKX2-1;CYP2A4;TGFB1
growth factor receptor bindingFYN;SLC9A3R1;SRC;APP
heparin bindingVEGFA;GPNMB;CECR1;PTPRF;LIPI;NRP1;RPL29;SELL;RSPO3
identical protein bindingSTK4;HSPB1;EWSR1;SLIT2;BNIP3;NME1;NOXO1;VCP;L1CAM
peptidase activator activityFBLN1;MMP14;PSME4;CLPX;FN1;PCOLCE2;CAV1;APP;MMP25
protein bindingWWC1;NPHS1;DOCK4;GNB5;MBD3;NEGR1;EYA3;TSGA10IP;LRRC26
receptor bindingTMEM38A;ITGA1;HLA-F;TNFSF4;MIF;PTK2AA;CADM2A;FGF6A;SLC9A3R1
serine-type endopeptidase inhibitor activityCOL6A3;SPINK11;SERPINE2;SERPINB12;SPINT2;FURIN;WFDC10A;SERPINB6;MUG1
transition metal ion bindingAPLP1;APPB;APPA;APP;APLP2;HRSP12

APP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with APP here. Most of them are supplied by our site. Hope this information will be useful for your research of APP.

Lee, HJ; Kwon, TY; et al. In Vitro Evaluation of Hydroxyapatite-Coated Titanium Implant with Atmospheric Plasma Treatment. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY 15:5593-5596(2015).
Chuang, YT; et al. SSCLS: A Smartphone-Supported Collaborative Learning System. TELEMATICS AND INFORMATICS 32:463-474(2015).
  • Q&As
  • Reviews

Q&As (18)

Ask a question
Are there any ongoing research efforts targeting the APP protein for Alzheimer's disease treatment? 04/26/2023

Yes, there is ongoing research focused on developing therapies that target the APP protein and its associated pathways in Alzheimer's disease. These include clinical trials investigating the effectiveness of anti-amyloid antibodies, small molecule inhibitors of amyloid-beta production, and modulators of APP processing enzymes. Additionally, other approaches targeting downstream processes related to APP or amyloid-beta toxicity are also being explored.

How does the APP protein contribute to synaptic dysfunction in Alzheimer's disease? 04/10/2023

The excessive accumulation of amyloid-beta peptides in Alzheimer's disease leads to synaptic dysfunction and loss. Amyloid-beta can disrupt neurotransmitter signaling, impair synaptic plasticity, and induce inflammation, ultimately leading to cognitive impairment and memory deficits commonly observed in Alzheimer's disease.

Are there any potential therapeutic strategies targeting APP protein dysregulation? 11/08/2022

Yes, there are various therapeutic strategies being explored to target APP protein dysregulation in Alzheimer's disease. One approach is to reduce the production or aggregation of amyloid-beta, which is derived from APP cleavage. This can be done through the use of small molecule inhibitors or antibodies that target the enzymes involved in APP cleavage or amyloid-beta aggregation. Another approach is to modulate the expression or processing of APP itself, aiming to reduce the production of amyloid-beta.

How is the APP protein processed and cleaved in the brain? 08/28/2022

The APP protein can undergo two main pathways of processing. The non-amyloidogenic pathway involves the cleavage of APP by alpha-secretase, producing soluble APP-alpha (sAPPα) and preventing the formation of amyloid-beta. The amyloidogenic pathway involves sequential cleavage by beta-secretase and gamma-secretase, resulting in the generation of amyloid-beta peptides of various lengths.

Are there any therapeutic strategies targeting the APP protein in Alzheimer's disease? 02/28/2022

Numerous therapeutic strategies have been explored to target the APP protein and the production of amyloid-beta in Alzheimer's disease. These include inhibiting the enzymes responsible for amyloid-beta formation (beta-secretase and gamma-secretase), immunotherapies targeting amyloid-beta, and modulating APP processing and trafficking.

Are there any non-genetic factors that can influence APP protein dysregulation? 01/20/2022

Yes, certain lifestyle and environmental factors have been associated with increased APP protein dysregulation. For example, chronic oxidative stress, inflammation, and metabolic dysfunction can impact APP processing and amyloid-beta production. Additionally, lifestyle choices such as a sedentary lifestyle, poor diet, and chronic stress may also contribute to APP dysregulation and the risk of developing Alzheimer's disease.

Can imaging techniques detect amyloid-beta plaques in the brain? 08/11/2021

Yes, there are several imaging techniques, such as positron emission tomography (PET) using specific radioactive tracers, that can detect and quantify amyloid-beta plaque deposition in the brain. These imaging modalities are clinically used to support the diagnosis of Alzheimer's disease and monitor disease progression.

Can the APP protein be targeted for diagnostic purposes? 08/07/2020

While the measurement of APP protein levels or its cleavage products in biological samples has shown promise as a diagnostic tool for Alzheimer's disease, it is not currently used in routine clinical practice. The sensitivity and specificity of these measurements need to be further improved to ensure their accuracy and reliability for diagnostic purposes.

Is the APP protein involved in any other diseases or conditions? 06/11/2019

Besides its role in Alzheimer's disease, the APP protein has been implicated in other neurodegenerative disorders such as Down syndrome and cerebral amyloid angiopathy. Additionally, it may play a role in certain types of cancers, as altered APP expression has been observed in some tumors.

Are there any known risk factors associated with APP protein dysregulation? 05/14/2019

While genetic mutations in the APP gene are associated with familial Alzheimer's disease, there are also other risk factors that can influence APP protein dysregulation. Age is the most significant risk factor, as the incidence of Alzheimer's disease increases with age. Other factors such as genetic variations in other genes, lifestyle choices (e.g., smoking, diet, exercise), and environmental factors may also contribute to APP protein dysregulation and the development of the disease.

Can changes in APP protein expression or processing be detected in animal models of Alzheimer's disease? 02/01/2019

Yes, animal models of Alzheimer's disease play an important role in studying changes in APP protein expression and processing. These models mimic certain aspects of Alzheimer's disease pathology, enabling researchers to investigate the effects of genetic and environmental manipulations on APP metabolism and amyloid-beta production. They help in understanding disease mechanisms and testing potential therapeutic interventions.

Can the APP protein be measured in biological samples for diagnostic purposes? 01/16/2019

Yes, the measurement of APP protein or its cleavage products can be performed in cerebrospinal fluid (CSF) and blood samples. These measurements are explored for their potential diagnostic value and monitoring disease progression in Alzheimer's disease. However, they are not currently used as routine diagnostic tools due to limitations in sensitivity and specificity.

What are the potential functions of amyloid-beta produced from APP cleavage? 01/24/2018

The functional role of amyloid-beta peptides is not entirely clear. Some studies suggest that amyloid-beta may have antimicrobial properties, play a role in synaptic activity, or act as a neuroprotectant. However, it is thought that abnormal accumulation of amyloid-beta contributes to neurotoxicity and neurodegeneration in Alzheimer's disease.

Does the APP protein have any known physiological roles outside the brain? 09/27/2017

Yes, the APP protein is not limited to the brain and has been found in various tissues and cell types throughout the body. While its function outside the brain is less understood, studies suggest its involvement in processes such as cell adhesion, wound healing, fertilization, and tissue repair. However, further research is needed to fully elucidate its physiological roles beyond the brain.

Are there any known compounds or drugs that can modulate APP protein expression or processing? 04/18/2017

Several compounds and drugs have shown potential in modulating APP protein expression or processing in preclinical and clinical studies. Examples include gamma-secretase inhibitors, beta-secretase inhibitors, and anti-amyloid antibodies. However, the development of effective and safe therapeutic interventions targeting APP dysregulation remains an active area of research.

Are there any genetic mutations or variants associated with the APP gene? 03/07/2017

Yes, mutations or variations in the APP gene have been identified in some familial forms of Alzheimer's disease. These mutations can increase the production or accumulation of amyloid-beta plaques, leading to an earlier onset and more aggressive form of the disease.

How is the expression or processing of APP protein regulated? 10/21/2016

The expression and processing of APP protein are regulated by various mechanisms. Transcriptional regulation plays a role in controlling APP expression, where different transcription factors can influence its production. Moreover, post-translational modifications, such as phosphorylation and glycosylation, can affect APP processing pathways. Enzymes involved in APP cleavage, including beta-secretase (BACE1) and gamma-secretase, are also regulated and can influence the generation of amyloid-beta.

How is the APP protein associated with Alzheimer's disease? 05/22/2016

In Alzheimer's disease, the APP protein undergoes abnormal processing, leading to the production and accumulation of amyloid-beta (Aβ) plaques in the brain. These plaques are a hallmark feature of the disease and are believed to contribute to neurodegeneration and cognitive decline.

Customer Reviews (4)

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Reviews
11/19/2021

    This can be advantageous in understanding disease mechanisms and developing novel therapeutics.

    07/28/2019

      APP protein is highly recommended for various research applications, including ELISA and protein electron microscopy structure analysis.

      12/23/2017

        The manufacturer can provide detailed documentation on the quality control measures undertaken during protein production and purification.

        04/29/2016

          APP protein might have biomarker properties, meaning its levels or activity could be indicative of disease progression or treatment response.

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