Recombinant Human HGS Protein, MYC/DDK-tagged
Cat.No. : | HGS-251H |
Product Overview : | Recombinant Human HGS fused with MYC/DDK tag at C-terminal was expressed in HEK293. |
- Specification
- Gene Information
- Related Products
Description : | Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation. |
Source : | HEK293 |
Species : | Human |
Tag : | MYC/DDK |
Form : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Molecular Mass : | 86 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Concentration : | >50 ug/mL as determined by microplate BCA method |
Gene Name : | HGS hepatocyte growth factor-regulated tyrosine kinase substrate [ Homo sapiens ] |
Official Symbol : | HGS |
Synonyms : | HGS; hepatocyte growth factor-regulated tyrosine kinase substrate; Hrs; Vps27; ZFYVE8; protein pp110; human growth factor-regulated tyrosine kinase substrate; HRS; FLJ11421; FLJ39878; |
Gene ID : | 9146 |
mRNA Refseq : | NM_004712 |
Protein Refseq : | NP_004703 |
MIM : | 604375 |
UniProt ID : | O14964 |
Products Types
◆ Recombinant Protein | ||
HGS-2492R | Recombinant Rat HGS Protein, His (Fc)-Avi-tagged | +Inquiry |
HGS-2238H | Recombinant Human HGS Protein, His-tagged | +Inquiry |
Hgs-1123M | Recombinant Mouse Hgs Protein, MYC/DDK-tagged | +Inquiry |
HGS-4732H | Recombinant Human HGS Protein, GST-tagged | +Inquiry |
HGS-1896R | Recombinant Rhesus Macaque HGS Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
HGS-783HCL | Recombinant Human HGS cell lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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