Recombinant Human HGS Protein, GST-tagged
Cat.No. : | HGS-4732H |
Product Overview : | Human HGS full-length ORF ( NP_004703.1, 1 a.a. - 777 a.a.) recombinant protein with GST-tag at N-terminal. |
- Specification
- Gene Information
- Related Products
Description : | The protein encoded by this gene regulates endosomal sorting and plays a critical role in the recycling and degradation of membrane receptors. The encoded protein sorts monoubiquitinated membrane proteins into the multivesicular body, targeting these proteins for lysosome-dependent degradation. [provided by RefSeq, Dec 2010] |
Source : | Wheat Germ |
Species : | Human |
Tag : | GST |
Molecular Mass : | 112.6 kDa |
AA Sequence : | MGRGSGTFERLLDKATSQLLLETDW ESILQICDLIRQGDTQAKYAVNSIK KKVNDKNPHVALYALEVMESVVKNC GQTVHDEVANKQTMEELKDLLKRQV EVNVRNKILYLIQAWAHAFRNEPKY KVVQDTYQIMKVEGHVFPEFKESDA MFAAERAPDWVDAEECHRCRVQFGV MTRKHHCRACGQIFCGKCSSKYSTI PKFGIEKEVRVCEPCYEQLNRKAEG KATSTTELPPEYLTSPLSQQSQLPP KRDETALQEEEELQLALALSQSEAE EKERLRQKSTYTSYPKAEPMPSASS APPASSLYSSPVNSSAPLAEDIDPE LARYLNRNYWEKKQEEARKSPTPSA PVPLTEPAAQPGEGHAAPTNVVENP LPETDSQPIPPSGGPFSEPQFHNGE SEESHEQFLKALQNAVTTFVNRMKS NHMRGRSITNDSAVLSLFQSINGMH PQLLELLNQLDERRLYYEGLQDKLA QIRDARGALSALREEHREKLRRAAE EAERQRQIQLAQKLEIMRQKKQEYL EVQRQLAIQRLQEQEKERQMRLEQQ KQTVQMRAQMPAFPLPYAQLQAMPA AGGVLYQPSGPASFPSTFSPAGSVE GSPMHGVYMSQPAPAAGPYPSMPST AADPSMVSAYMYPAGATGAQAAPQA QAGPTASPAYSSYQPTPTAGYQNVA SQAPQSLPAISQPPQSSTMGYMGSQ SVSMGYQPYNMQNLMTTLPSQDASL PPQQPYIAGQQPMYQQMAPSGGPPQ QQPPVAQQPQAQGPPAQGSEAQLIS FD |
Applications : | Enzyme-linked Immunoabsorbent Assay Western Blot (Recombinant protein) Antibody Production Protein Array |
Notes : | Best use within three months from the date of receipt of this protein. |
Storage : | Store at -8 centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | HGS hepatocyte growth factor-regulated tyrosine kinase substrate [ Homo sapiens ] |
Official Symbol : | HGS |
Synonyms : | HGS; hepatocyte growth factor-regulated tyrosine kinase substrate; Hrs; Vps27; ZFYVE8; protein pp110; human growth factor-regulated tyrosine kinase substrate; HRS; FLJ11421; FLJ39878; |
Gene ID : | 9146 |
mRNA Refseq : | NM_004712 |
Protein Refseq : | NP_004703 |
MIM : | 604375 |
UniProt ID : | O14964 |
Products Types
◆ Recombinant Protein | ||
HGS-1068H | Recombinant Human HGS Protein, His (Fc)-Avi-tagged | +Inquiry |
HGS-251H | Recombinant Human HGS Protein, MYC/DDK-tagged | +Inquiry |
HGS-1896R | Recombinant Rhesus Macaque HGS Protein, His (Fc)-Avi-tagged | +Inquiry |
HGS-2492R | Recombinant Rat HGS Protein, His (Fc)-Avi-tagged | +Inquiry |
Hgs-1123M | Recombinant Mouse Hgs Protein, MYC/DDK-tagged | +Inquiry |
◆ Lysates | ||
HGS-783HCL | Recombinant Human HGS cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionHGS contributes to the regulation of cell signaling by promoting the downregulation of activated receptors in the endocytic pathway.
Dysregulation or abnormal expression of HGS is associated with conditions such as cancer and neurodegenerative disorders.
HGS participates in the endocytic pathway by facilitating the degradation of receptor tyrosine kinases (RTKs) through the ESCRT complex.
Hepatocyte growth factor-regulated tyrosine kinase substrate (HGS) functions in cellular processes, primarily playing a role in intracellular trafficking.
HGS is predominantly localized in endosomes and lysosomes, key compartments for the endocytic pathway.
Specific interactions or binding partners of HGS include ESCRT components, influencing its role in receptor downregulation and intracellular trafficking.
There are potential therapeutic implications related to HGS in diseases involving intracellular trafficking and signaling, making it a target for drug development.
Customer Reviews (3)
Write a reviewMinimal background noise in our assays was indicative of the product's superior quality.
Compatibility with a range of assays expanded our research possibilities significantly.
Our research benefited greatly from the product's ability to induce specific cellular responses, enriching our findings.
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