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Recombinant Human HGS Protein, GST-tagged

Cat.No. : HGS-4732H
Product Overview : Human HGS full-length ORF ( NP_004703.1, 1 a.a. - 777 a.a.) recombinant protein with GST-tag at N-terminal.
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  • Gene Information
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Description : The protein encoded by this gene regulates endosomal sorting and plays a critical role in the recycling and degradation of membrane receptors. The encoded protein sorts monoubiquitinated membrane proteins into the multivesicular body, targeting these proteins for lysosome-dependent degradation. [provided by RefSeq, Dec 2010]
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 112.6 kDa
AA Sequence : MGRGSGTFERLLDKATSQLLLETDW ESILQICDLIRQGDTQAKYAVNSIK KKVNDKNPHVALYALEVMESVVKNC GQTVHDEVANKQTMEELKDLLKRQV EVNVRNKILYLIQAWAHAFRNEPKY KVVQDTYQIMKVEGHVFPEFKESDA MFAAERAPDWVDAEECHRCRVQFGV MTRKHHCRACGQIFCGKCSSKYSTI PKFGIEKEVRVCEPCYEQLNRKAEG KATSTTELPPEYLTSPLSQQSQLPP KRDETALQEEEELQLALALSQSEAE EKERLRQKSTYTSYPKAEPMPSASS APPASSLYSSPVNSSAPLAEDIDPE LARYLNRNYWEKKQEEARKSPTPSA PVPLTEPAAQPGEGHAAPTNVVENP LPETDSQPIPPSGGPFSEPQFHNGE SEESHEQFLKALQNAVTTFVNRMKS NHMRGRSITNDSAVLSLFQSINGMH PQLLELLNQLDERRLYYEGLQDKLA QIRDARGALSALREEHREKLRRAAE EAERQRQIQLAQKLEIMRQKKQEYL EVQRQLAIQRLQEQEKERQMRLEQQ KQTVQMRAQMPAFPLPYAQLQAMPA AGGVLYQPSGPASFPSTFSPAGSVE GSPMHGVYMSQPAPAAGPYPSMPST AADPSMVSAYMYPAGATGAQAAPQA QAGPTASPAYSSYQPTPTAGYQNVA SQAPQSLPAISQPPQSSTMGYMGSQ SVSMGYQPYNMQNLMTTLPSQDASL PPQQPYIAGQQPMYQQMAPSGGPPQ QQPPVAQQPQAQGPPAQGSEAQLIS FD
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -8 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : HGS hepatocyte growth factor-regulated tyrosine kinase substrate [ Homo sapiens ]
Official Symbol : HGS
Synonyms : HGS; hepatocyte growth factor-regulated tyrosine kinase substrate; Hrs; Vps27; ZFYVE8; protein pp110; human growth factor-regulated tyrosine kinase substrate; HRS; FLJ11421; FLJ39878;
Gene ID : 9146
mRNA Refseq : NM_004712
Protein Refseq : NP_004703
MIM : 604375
UniProt ID : O14964

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How does HGS contribute to the regulation of cell signaling and receptor downregulation in the endocytic pathway? 05/10/2022

HGS contributes to the regulation of cell signaling by promoting the downregulation of activated receptors in the endocytic pathway.

What diseases or conditions are associated with dysregulation or abnormal expression of HGS? 02/28/2022

Dysregulation or abnormal expression of HGS is associated with conditions such as cancer and neurodegenerative disorders.

How does HGS participate in the endocytic pathway, particularly in the degradation of receptor tyrosine kinases (RTKs)? 02/08/2022

HGS participates in the endocytic pathway by facilitating the degradation of receptor tyrosine kinases (RTKs) through the ESCRT complex.

What is the primary function of Hepatocyte growth factor-regulated tyrosine kinase substrate (HGS) in cellular processes and intracellular trafficking? 02/07/2020

Hepatocyte growth factor-regulated tyrosine kinase substrate (HGS) functions in cellular processes, primarily playing a role in intracellular trafficking.

In which cellular compartments is HGS predominantly localized? 11/12/2019

HGS is predominantly localized in endosomes and lysosomes, key compartments for the endocytic pathway.

Are there specific interactions or binding partners of HGS that influence its role in intracellular trafficking? 04/09/2019

Specific interactions or binding partners of HGS include ESCRT components, influencing its role in receptor downregulation and intracellular trafficking.

Are there therapeutic implications or potential targets related to HGS in diseases involving intracellular trafficking and signaling? 04/30/2018

There are potential therapeutic implications related to HGS in diseases involving intracellular trafficking and signaling, making it a target for drug development.

Customer Reviews (3)

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Reviews
05/13/2019

    Minimal background noise in our assays was indicative of the product's superior quality.

    01/24/2018

      Compatibility with a range of assays expanded our research possibilities significantly.

      12/19/2016

        Our research benefited greatly from the product's ability to induce specific cellular responses, enriching our findings.

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