| Description : |
This gene encodes a member of the HIN-200 (hematopoietic interferon-inducible nuclear antigens with 200 amino acid repeats) family of cytokines. The encoded protein contains domains involved in DNA binding, transcriptional regulation, and protein-protein interactions. The protein localizes to the nucleoplasm and nucleoli, and interacts with p53 and retinoblastoma-1. It modulates p53 function, and inhibits cell growth in the Ras/Raf signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2011] |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
81.9 kDa |
| AA Sequence : |
MGKKYKNIVLLKGLEVINDYHFRMV KSLLSNDLKLNLKMREEYDKIQIAD LMEEKFRGDAGLGKLIKIFEDIPTL EDLAETLKKEKLKVKGPALSRKRKK EVHATSPAPSTSSTVKTEGAEATPG AQKRKKSTKEKAGPKGSKVSEEQTQ PPSPAGAGMSTAMGRSPSPKTSLSA PPNSSSTENPKTVAKCQVTPRRNVL QKRPVIVKVLSTTKPFEYETPEMEK KIMFHATVATQTQFFHVKVLNTSLK EKFNGKKIIIISDYLEYDSLLEVNE ESTVSEAGPNQTFEVPNKIINRAKE TLKIDILHKQASGNIVYGVFMLHKK TVNQKTTIYEIQDDRGKMDVVGTGQ CHNIPCEEGDKLQLFCFRLRKKNQM SKLISEMHSFIQIKKKTNPRNNDPK SMKLPQEQRQLPYPSEASTTFPESH LRTPQMPPTTPSSSFFTKKSEDTIS KMNDFMRMQILKEGSHFPGPFMTSI GPAESHPHTPQMPPSTPSSSFLTTL KPRLKTEPEEVSIEDSAQSDLKEVM VLNATESFVYEPKEQKKMFHATVAT ENEVFRVKVFNIDLKEKFTPKKIIA IANYVCRNGFLEVYPFTLVADVNAD RNMEIPKGLIRSASVTPKINQLCSQ TKGSFVNGVFEVHKKNVRGEFTYYE IQDNTGKMEVVVHGRLNTINCEEGD KLKLTSFELAPKSGNTGELRSVIHS HIKVIKTRKNKKDILNPDSSMETSP DFFFTRTRPLEQKLISEEDLAANDI LDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
