IFI16
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Official Full Name
interferon, gamma-inducible protein 16 -
Overview
IFI16 belongs to the PYHIN family, which consists of four members in humans (Aim2, IFIX, MNDA, and IFI16) and at least thirteen members in mice. The closest homolog of IFI16 in mice is p204. The PYHIN family is characterized by the presence of one or two -
Synonyms
IFI16;interferon, gamma-inducible protein 16;gamma-interferon-inducible protein 16;IFNGIP1;PYHIN2;interferon-gamma induced protein IFI 16;interferon-inducible myeloid differentiation transcriptional activator;MGC9466
Recombinant Proteins
- Human
- Rhesus macaque
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- GST
- His
- T7
- Non
- Flag
- Avi
- Fc
- DDK
- Myc
Involved Pathway
IFI16 involved in several pathways and played different roles in them. We selected most pathways IFI16 participated on our site, such as Cytosolic sensors of pathogen-associated DNA,IRF3-mediated induction of type I IFN,Id Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IFI16 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| IRF3-mediated induction of type I IFN | TREX1,NLRP4E,NLRP4C,DDX41,NLRP4B,NLRP4 |
| Immune System | GBP4,SIGLEC10,CD300E,KIFAP3,ATP6V1G3,CXADR,Mill2,CD200R4,BTR12,IFI27 |
| Senescence and Autophagy | GABARAP,ATG7,AMBRA1,MAP1LC3C,SLC39A1,COL10A1,GABARAPL2,RB1CC1,SLC39A2,SLC39A3 |
| STING mediated induction of host immune responses | MB21D1,NLRP4E,DDX41,NLRP4C,TREX1,NLRP4B,NLRP4 |
| Cytosolic sensors of pathogen-associated DNA | MB21D1,POLR3H,CRCP,LRRFIP1,POLR3F,TICAM1,NLRP4C,RIPK3,TRIM56,S100B |
| Id Signaling Pathway | MYOD1,MYF6,KDR,ELK3,MYOG,TCF12,ACVRL1,PAX2,MSC,TCF3B |
| Innate Immune System | WASF3,DEFB103A,PPAPDC1A,CD300E,DEFA6,CLEC6A,NLRP4E,SIRPB1,PPAPDC1B,IRAK3 |
Protein Function
IFI16 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding,core promoter binding,double-stranded DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IFI16 itself. We selected most functions IFI16 had, and list some proteins which have the same functions with IFI16. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| identical protein binding | HACL1,CEP57L1,GLE1,GOT1,CLDN2,IAPP,SRPX2,NISCH,C1QTNF9,SLK |
| transcription factor binding | KAT2A,PIANP,SIRT1,GNPTAB,FOXO1,E2F5,SP100,NLRP3,PPARG,BPTF |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | NKX6-1,JUND,RFX3,GLI3,ZFP746,PAX5,NEUROG3,POU1F1,ZNF680,JDP2 |
| double-stranded DNA binding | RAD51L1,HNRPDL,TRP53,DMC1,SATB1,TDG,KLF6,NKX2-8,NTHL1,HMGB2 |
| poly(A) RNA binding | WIBG,S100A4,DCN,EIF3D,EIF5A,PRAC,TRA2A,HNRNPK,FAM120B,MYH9 |
| transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding | ZFPM2A,ZGPAT,ETS2,BCL11AB,HINFP,CTCF,NFIL3-6,BATF3,NKX3-2,BCL11A |
| core promoter binding | NOTCH1,XBP1,GTF2B,PYDC3,ELK1,CLOCK,NEUROG3,KLF4,MYBBP1A,DHX36 |
| protein binding | NCAPH2,VAC14,TRDN,URM1,SSTR3,GRHL2,KCNIP2,GPR85,PPARD,SCMH1 |
Interacting Protein
IFI16 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IFI16 here. Most of them are supplied by our site. Hope this information will be useful for your research of IFI16.
BRCA1;AR;TMEM173;TP53;SP1;Tmem173;q7ard3_yerpe;hofG
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References
- Connolly, DJ; Bowie, AG; et al. The emerging role of human PYHIN proteins in innate immunity: Implications for health and disease. BIOCHEMICAL PHARMACOLOGY 92:405-414(2014).
- Suzuki, T; Oshiumi, H; et al. Cell Type-Specific Subcellular Localization of Phospho-TBK1 in Response to Cytoplasmic Viral DNA. PLOS ONE 8:-(2013).
