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Official Full Name interferon, gamma-inducible protein 16
Background IFI16 belongs to the PYHIN family, which consists of four members in humans (Aim2, IFIX, MNDA, and IFI16) and at least thirteen members in mice. The closest homolog of IFI16 in mice is p204. The PYHIN family is characterized by the presence of one or two
Synonyms IFI16; interferon, gamma-inducible protein 16; gamma-interferon-inducible protein 16; IFNGIP1; PYHIN2; interferon-gamma induced protein IFI 16; interferon-inducible myeloid differentiation transcriptional activator; MGC9466
    • Species :
    • Human
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • C-Myc/DDK
    • GST
    • His
    • T7
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human IFI16-14060H Recombinant Human IFI16, GST-tagged E.coli GST
    Human IFI16-1946H Recombinant Human IFI16 protein, His & T7-tagged E.coli His/T7
    Human IFI16-195H Recombinant Human IFI16 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
    Human IFI16-26947TH Recombinant Human IFI16 Wheat Germ N/A
    Human IFI16-5297HCL Recombinant Human IFI16 293 Cell Lysate HEK293 N/A
    Rhesus Macaque IFI16-2197R Recombinant Rhesus monkey IFI16 Protein, His-tagged Mammalian Cell His

    ifi16 involved in several pathways and played different roles in them. We selected most pathways ifi16 participated on our site, such as Cytosolic sensors of pathogen-associated DNA, IRF3-mediated induction of type I IFN, Id Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ifi16 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytosolic sensors of pathogen-associated DNA SAA1; TICAM1; CRCP; POLR3F; IFI16; MB21D1; NLRP4; RIPK3; DDX41; POLR3C
    IRF3-mediated induction of type I IFN TREX1; NLRP4C; NLRP4B; IFI16; NLRP4; NLRP4E; DDX41
    Id Signaling Pathway MYOG; IFI16; TCF12; MYF6; PAX2; ELK3; KDR; MSC; ACVRL1; TCF3B
    Immune System KLRF1; MASP2; SPSB2; CRCP; RNF14; AF251705; FCN3; RAP1GAP2; ERAP1; TRIM14
    STING mediated induction of host immune responses MB21D1; NLRP4B; NLRP4E; TREX1; NLRP4; IFI16; NLRP4C; DDX41
    Senescence and Autophagy ING1; ATG7; RB1CC1; MAP1LC3B; AMBRA1; IGFBP5; MAP1LC3C; UVRAG; SLC39A1; ING2

    ifi16 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding, core promoter binding, double-stranded DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ifi16 itself. We selected most functions ifi16 had, and list some proteins which have the same functions with ifi16. You can find most of the proteins on our site.

    Function Related Protein
    RNA polymerase II core promoter proximal region sequence-specific DNA binding SALL1; OTX1; MXD1; SMAD4; PGR; GMEB1; NFATC3; HLTF; HNRNPC; SREBF2
    core promoter binding HDAC2; ELK4; NKX3-1; MYOD1; INSM1B; CCAR1; ELK1; KDM3A; IFI16; MTA1
    double-stranded DNA binding NEIL3; TP73; RAD51B; SETMAR; CGGBP1; HNRPDL; MCM10; CTNNB1; SP8B; IFI203
    identical protein binding DAPK2; C; ATXN3; NOL3; CLDN6; DPY30; EID3; TRA@; FUS; C1QL4
    poly(A) RNA binding MAGOH2; WDR36; ZC3HAV1; DIAP1; HARS2; PPP1R2P9; P4HB; RRP8; AKAP17A; NCBP1
    transcription factor binding INSIG2; PPP1R13BA; CAMTA2; PITX2; MAPK1; E2F1; HHEX; NFATC2; GTF2B; STK4
    transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding ZGPAT; ATF7; BACH1; PROX1A; PROX1B; SFPI1; REST; BATF3; PROX1; NFIL3-5

    ifi16 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ifi16 here. Most of them are supplied by our site. Hope this information will be useful for your research of ifi16.

    BRCA1; AR; TMEM173; TP53; SP1; Tmem173; q7ard3_yerpe; hofG

    Connolly, DJ; Bowie, AG; et al. The emerging role of human PYHIN proteins in innate immunity: Implications for health and disease. BIOCHEMICAL PHARMACOLOGY 92:405-414(2014).
    Suzuki, T; Oshiumi, H; et al. Cell Type-Specific Subcellular Localization of Phospho-TBK1 in Response to Cytoplasmic Viral DNA. PLOS ONE 8:-(2013).

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