Recombinant Mouse Pak5 Protein, Myc/DDK-tagged

• Cat.No.: Pak5-4664M
• Product Overview: Purified recombinant protein of mouse full-length p21 (RAC1) activated kinase 7 (Pak7), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates the proto-oncogene RAF1 and stimulates its kinase activity. Promotes cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Phosphorylates CTNND1, probably to regulate cytoskeletal organization and cell morphology. Keeps microtubules stable through MARK2 inhibition and destabilizes the F-actin network leading to the disappearance of stress fibers and focal adhesions.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 81.4 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Pak5 p21 (RAC1) activated kinase 5 [ Mus musculus (house mouse) ]
• Official Symbol: Pak5
• Synonyms: PAK7; p21 protein (Cdc42/Rac)-activated kinase 7; serine/threonine-protein kinase PAK 7; PAK-5; PAK-7; p21-activated kinase 5; p21-activated kinase 7; Pak5; 6430627N20; 2900083L08Rik; MGC117585
• Gene ID: 241656
• mRNA Refseq: NM_172858
• Protein Refseq: NP_766446
• UniProt ID: Q8C015