Recombinant Mouse Paxx Protein, Myc/DDK-tagged

• Cat.No.: Paxx-4689M
• Product Overview: Purified recombinant protein of mouse full-length non-homologous end joining factor (Paxx), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Involved in non-homologous end joining (NHEJ), a major pathway to repair double-strand breaks in DNA. May act as a scaffold required to stabilize the Ku heterodimer, composed of XRCC5/Ku80 and XRCC6/Ku70, at DNA ends and thus promote assembly and/or stability of the NHEJ machinery at double-strand break sites.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 22 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Paxx non-homologous end joining factor [ Mus musculus (house mouse) ]
• Official Symbol: Paxx
• Synonyms: Paxx; non-homologous end joining factor; D930050G13Rik; protein PAXX; paralog of XRCC4 and XLF
• Gene ID: 227622
• mRNA Refseq: NM_153557
• Protein Refseq: NP_705785
• UniProt ID: Q8K0Y7