"KARS" Related Products

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Recombinant Human KARS, His-tagged

Cat. No.: KARS-1010H
Product Overview: Recombinant human KARS protein, fused to His-tag at N-terminus, was expressed in E.coliand purified by using conventional chromatography.
Description: KARS, also known as Lysyl-tRNAsynthetase, belongs to the class-II aminoacyl-tRNAsynthetase family. It exists as both mitochondrial and cytoplasmic isoforms produced by alternative splicing, and thought to play a role in autoimmune diseases, such as polymyositis or dermatomyositis. This protein functions to catalyze the aminoacylation of tRNAs by their corresponding amino acids, thus linking amino acids with tRNA-contained nucleotide triplets.
Form: Liquid. 20mM Tris-HCl buffer (pH8.0) containing 20% glycerol, 0.1M NaCl,1mM DTT
Molecular Weight: 63.7 kDa (558aa)
Purity: > 95% by SDS - PAGE
Concentration: 1.0 mg/ml (determined by Bradford assay)
Sequences of amino acids: MGSSHHHHHH SSGLVPRGSH MGSGVGPEEE SVDPNQYYKI RSQAIHQLKV NGEDPYPHKF HVDISLTDFI QKYSHLQPGD HLTDITLKVAGRIHAKRASG GKLIFYDLRG EGVKLQVMAN SRNYKSEEEF IHINNKLRRG DIIGVQGNPG KTKKGELSII PYEITLLSPC LHMLPHLHFGLKDKETRYRQ RYLDLILNDF VRQKFIIRSK IITYIRSFLD ELGFLEIETP MMNIIPGGAV AKPFITYHNE LDMNLYMRIA PELYHKMLVVGGIDRVYEIG RQFRNEGIDL THNPEFTTCE FYMAYADYHD LMEITEKMVS GMVKHITGSY KVTYHPDGPE GQAYDVDFTP PFRRINMVEELEKALGMKLP ETNLFETEET RKILDDICVA KAVECPPPRT TARLLDKLVG EFLEVTCINP TFICDHPQIM SPLAKWHRSK EGLTERFELFVMKKEICNAY TELNDPMRQR QLFEEQAKAK AAGDDEAMFI DENFCTALEY GLPPTAGWGM GIDRVAMFLT DSNNIKEVLL FPAMKPEDKKENVATTDTLE STTVGTSV
Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C.Avoid repeated freezing and thawing cycles.
Gene Name: KARS lysyl-tRNA synthetase [ Homo sapiens ]
Official Symbol: KARS
Synonyms: KARS; KRS; KARS2; CMTRIB; KIAA0070; lysyl-tRNAsynthetase;lysRS; OTTHUMP00000174948; OTTHUMP00000174949; lysine tRNA ligase; EC 6.1.1.6; Lysine--tRNA ligase
Gene ID: 3735
mRNA Refseq: NM_001130089
Protein Refseq: NP_001123561
MIM: 601421
UniProt ID: Q15046
Chromosome Location: 16q23.1
Function: ATP binding; ligase activity; lysine-tRNA ligase activity; metal ion binding; nucleic acid binding; nucleotide binding; tRNA binding

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