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Recombinant Human Mevalonate (diphospho) Decarboxylase, His-tagged

Cat. No.: MVD-1569H
Product Overview: Recombinant human MVD protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.
Description: MVD, also known as diphosphomevalonate decarboxylase, catalyzes the conversion of mevalonate pyrophosphate into isopentenyl pyrophosphate in one of the early steps in cholesterol biosynthesis. It decarboxylates and dehydrates its substrate while hydrolyzing ATP.
Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 20% glycerol, 1mM DTT.
Molecular Weight: 45.6 kDa (420aa), confirmed by MALDI-TOF.
Purity: >85% by SDS-PAGE
Concentration: 0.5 mg/ml (determined by Bradford assay)
Sequences of amino acids: MGSSHHHHHH SSGLVPRGSH MASEKPLAAV TCTAPVNIAV IKYWGKRDEE LVLPINSSLS VTLHQDQLKT TTTAVISKDF TEDRIWLNGR EEDVGQPRLQ ACLREIRCLA RKRRNSRDGD PLPSSLSCKV HVASVNNFPT AAGLASSAAG YACLAYTLAR VYGVESDLSE VARRGSGSAC RSLYGGFVEW QMGEQADGKD SIARQVAPES HWPELRVLIL VVSAEKKLTG STVGMRASVE TSPLLRFRAE SVVPARMAEM ARCIRERDFP SFAQLTMKDS NQFHATCLDT FPPISYLNAI SWRIIHLVHR FNAHHGDTKV AYTFDAGPNA VIFTLDDTVA EFVAAVWHGF PPGSNGDTFL KGLQVRPAPL SAELQAALAM EPTPGGVKYI IVTQVGPGPQ ILDDPCAHLL GPDGLPKPAA
Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Pathways: Cholesterol Biosynthesis; Metabolic pathways; Metabolism of lipids and lipoproteins; Terpenoid backbone biosynthesis; mevalonate pathway I; superpathway of cholesterol biosynthesis; superpathway of geranylgeranyldiphosphate
Gene Name: MVD mevalonate (diphospho) decarboxylase [ Homo sapiens ]
Official Symbol: MVD
Synonyms: MVD; mevalonate (diphospho) decarboxylase; diphosphomevalonate decarboxylase; MDDase; OTTHUMP00000175197; mevalonate pyrophosphate decarboxylase; EC 4.1.1.33
Gene ID: 4597
mRNA Refseq: NM_002461
Protein Refseq: NP_002452
MIM: 603236
UniProt ID: P53602
Chromosome Location: 16q24.3
Function: ATP binding; Hsp70 protein binding; diphosphomevalonate decarboxylase activity; kinase activity; lyase activity; nucleotide binding; protein homodimerization activity

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