"TIMP2" Related Products


Recombinant Human TIMP2, His-tagged

Cat. No. : TIMP2-881H
Product Overview : Recombinant Human CSC-21K /TIMP2 Protein (rhTIMP2) Cys 27 - Pro 220 was produced in human 293 cells.
Description : This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix.
Source : HEK293 Cells
Molecular Mass : rhTIMP2, fused with 6×His tag at the C-terminus, has a calculated MW of 22.6 kDa. The predicted N-terminus is Cys 27. DTT-reduced Protein migrates as 22 kDa.
Endotoxin : Less than 1.0 EU per μg of the rhTIMP2 by the LAL method.
Formulation : Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 150 mM NaCl, 0.05% Brij-35, pH 7.5. Normally Mannitol or Trehalose are added as protectants before lyophilization.
Purity : >98% as determined by SDS-PAGE.
Reconstitution : See Certificate of Analysis for details of reconstitution instruction and specific concentration.
Storage : Avoid repeated freeze-thaw cycles. Store at -20oC to -70oC.
OfficialSymbol : TIMP2
Gene Name : TIMP2 TIMP metallopeptidase inhibitor 2 [ Homo sapiens ]
Synonyms : TIMP2; TIMP metallopeptidase inhibitor 2; CSC-21K; tissue inhibitor of metalloproteinase 2; tissue inhibitor of metalloproteinases 2; TIMP-2
Gene ID : 7077
mRNA Refseq : NM_003255
Protein Refseq : NP_003246
MIM : 188825
UniProt ID : P16035
Chromosome Location : 17q25
Pathway : Activation of Matrix Metalloproteinases; Degradation of the extracellular matrix; Extracellular matrix organization
Function : enzyme activator activity; integrin binding; metalloendopeptidase inhibitor activity

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