timp1

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timp1

Official Full Name TIMP metallopeptidase inhibitor 1
Background This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction. [provided by RefSeq, Jul 2008]
Synonyms TIMP1; TIMP metallopeptidase inhibitor 1; EPA; EPO; HCI; CLGI; TIMP; metalloproteinase inhibitor 1; TIMP-1; collagenase inhibitor; erythroid potentiating activity; erythroid-potentiating activity; fibroblast collagenase inhibitor; tissue inhibitor of metalloproteinases 1
    • Species :
    • Bovine
    • Dog
    • Horse
    • Human
    • Mouse
    • Rabbit
    • Rat
    • Rhesus Macaque
    • Sheep
    • Source :
    • Bovine Plasma
    • CHO
    • E.coli
    • HEK293
    • Human
    • Human Cell
    • Human Fibroblasts
    • Human Neutrophil
    • Insect Cell
    • Mammalian Cell
    • Mouse
    • NSO
    • Rabbit
    • Sf9 Insect Cell
    • Tag :
    • Fc
    • His
    • GST
    • T7
    • MBP
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CAB11616MH Mouse Monoclonal Antibody to Human TIMP Metallopeptidase Inhibitor 1 Mouse N/A
    Human CAB11617RH Rabbit Monoclonal Antibody to Human TIMP Metallopeptidase Inhibitor 1 Rabbit N/A
    Human TIMP1-001H Recombinant Human TIMP1 Protein, MBP-tagged E.coli MBP
    Human TIMP1-002H Recombinant Human TIMP1, HIgG1 Fc-tagged CHO Fc
    Human TIMP1-1688H Recombinant Human TIMP Metallopeptidase Inhibitor 1 NSO N/A
    Human TIMP1-2530H Recombinant Human TIMP Metallopeptidase Inhibitor 1 CHO N/A
    Human TIMP1-261H Recombinant Human TIMP1 Protein, Fc-tagged HEK293 Fc
    Human TIMP1-2678HCL Recombinant Human TIMP1 cell lysate Human Cell N/A
    Human TIMP1-287H Recombinant Human metallopeptidase inhibitor 1, His-tagged E.coli His
    Human TIMP1-2886H Recombinant Human TIMP Metallopeptidase Inhibitor 1 Sf9 Insect Cell N/A
    Human TIMP1-30303TH Recombinant Human TIMP1 E.coli N/A
    Human TIMP1-30304TH Recombinant Human TIMP1, His-tagged E.coli His
    Human TIMP1-30840TH Native Human TIMP1 Human Fibroblasts N/A
    Human TIMP1-30841TH Recombinant Human TIMP1, MBP-tagged E.coli MBP
    Human TIMP1-3194H Recombinant Human TIMP1, None tagged Human Cell N/A
    Human TIMP1-3241H Recombinant Human TIMP1, His-tagged E.coli His
    Human TIMP1-4764H Recombinant Human TIMP1 protein, His-tagged HEK293 His
    Human TIMP1-5140H Recombinant Human TIMP Metallopeptidase Inhibitor 1 Human N/A
    Human TIMP1-601H Recombinant Human TIMP1 Protein, His-tagged HEK293 His
    Human TIMP1-77H Recombinant Human TIMP1, His-tagged Insect Cell His
    Human TIMP1-878H Recombinant Human TIMP1, His tagged Human Cell His
    Human TIMP1-92H Native Human TIMP-1 Human Neutrophil N/A
    Mouse TIMP1-1034M Recombinant Mouse TIMP1 Protein, His-tagged HEK293 His
    Mouse TIMP1-2376MCL Recombinant Mouse TIMP1 cell lysate Human Cell N/A
    Mouse Timp1-2788M Recombinant Mouse Timp1 protein, His-tagged E.coli His
    Mouse Timp1-3285M Recombinant Mouse Timp1, None tagged Human Cell N/A
    Mouse Timp1-6436M Recombinant Mouse Timp1 Protein, His-tagged HEK293 His
    Mouse Timp1-69M Recombinant Mouse Timp1 protein, His-tagged Insect Cell His
    Rat TIMP1-1072R Recombinant Rat TIMP1 Protein HEK293 N/A
    Rat TIMP1-1490RCL Recombinant Rat TIMP1 cell lysate Human Cell N/A
    Rat Timp1-1798R Recombinant Rat TIMP Metallopeptidase Inhibitor 1 NSO N/A
    Rat Timp1-2790R Recombinant Rat Timp1 protein, His-tagged E.coli His
    Rat TIMP1-6076R Recombinant Rat TIMP1 Protein Mammalian Cell His
    Rat Timp1-61R Recombinant Rat Timp1 protein, His-tagged Insect Cell His
    Rhesus Macaque TIMP1-4722R Recombinant Rhesus monkey TIMP1 Protein, His-tagged Mammalian Cell His
    Dog TIMP1-2786D Recombinant Dog TIMP1 protein, His-tagged E.coli His
    Bovine TIMP1-91B Native Bovine Thrombin Bovine Plasma N/A
    Rabbit TIMP1-2791R Recombinant Rabbit TIMP1 protein, His-tagged E.coli His
    Horse TIMP1-2787H Recombinant Horse TIMP1 protein, His & GST-tagged E.coli His/GST
    Sheep TIMP1-2789S Recombinant Sheep TIMP1 protein, His & T7-tagged E.coli His/T7

    timp1 involved in several pathways and played different roles in them. We selected most pathways timp1 participated on our site, such as HIF- signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with timp1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    HIF- signaling pathway LDHA; HK1; LTBR; VHL; MTOR; MAPK3; EIF4E2; SLC2A1; MAPK1; PIK3CB

    timp1 has several biochemical functions, for example, cytokine activity, growth factor activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by timp1 itself. We selected most functions timp1 had, and list some proteins which have the same functions with timp1. You can find most of the proteins on our site.

    Function Related Protein
    cytokine activity NDR1; IFNG1-2; GM13279; TXLNA; LEFTY2; Il1f6; IL10; GM13278; GDF11; IFNPHI2
    growth factor activity INHA; PTN; GDF6; LEFTY1; FGF11; FGF10B; NODAL; COL20A1; BMP2; VEGFC
    metal ion binding CYP2K17; KCND3; GNA13; PRICKLE1A; APLF; FGD3; DOHH; ERI3; PRUNE; ZFP106
    metalloendopeptidase inhibitor activity RECK; WFIKKN1; TIMP2; SPOCK3; TIMP2A; LXN; BST2; TIMP2B; WFIKKN2; TIMP4
    protease binding TTN; FURIN; ADAMTS4; CRADD; TIMP2A; HSPD1; SERPINA1; FN1; ITGA3; UBC
    protein binding NLRC4; RGP1; PHF16; EID1; RBM15B; THOP1; IFT46; RPS6KA2; CEP72; KLKB1

    timp1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with timp1 here. Most of them are supplied by our site. Hope this information will be useful for your research of timp1.

    CD63; MMP9; RECQL5; EEF1B2; SUMO2; ECH1

    Shi, M; Movius, J; et al. Cerebrospinal Fluid Peptides as Potential Parkinson Disease Biomarkers: A Staged Pipeline for Discovery and Validation. MOLECULAR & CELLULAR PROTEOMICS 14:544-555(2015).
    Krabben, A; Huizinga, TWJ; et al. Biomarkers for Radiographic Progression in Rheumatoid Arthritis. CURRENT PHARMACEUTICAL DESIGN 21:147-169(2015).

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