|Official Full Name||TIMP metallopeptidase inhibitor 1|
|Background||This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction. [provided by RefSeq, Jul 2008]|
|Synonyms||TIMP1; TIMP metallopeptidase inhibitor 1; EPA; EPO; HCI; CLGI; TIMP; metalloproteinase inhibitor 1; TIMP-1; collagenase inhibitor; erythroid potentiating activity; erythroid-potentiating activity; fibroblast collagenase inhibitor; tissue inhibitor of metalloproteinases 1|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
timp1 involved in several pathways and played different roles in them. We selected most pathways timp1 participated on our site, such as HIF- signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with timp1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|HIF- signaling pathway||LDHA; HK1; LTBR; VHL; MTOR; MAPK3; EIF4E2; SLC2A1; MAPK1; PIK3CB|
timp1 has several biochemical functions, for example, cytokine activity, growth factor activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by timp1 itself. We selected most functions timp1 had, and list some proteins which have the same functions with timp1. You can find most of the proteins on our site.
|cytokine activity||NDR1; IFNG1-2; GM13279; TXLNA; LEFTY2; Il1f6; IL10; GM13278; GDF11; IFNPHI2|
|growth factor activity||INHA; PTN; GDF6; LEFTY1; FGF11; FGF10B; NODAL; COL20A1; BMP2; VEGFC|
|metal ion binding||CYP2K17; KCND3; GNA13; PRICKLE1A; APLF; FGD3; DOHH; ERI3; PRUNE; ZFP106|
|metalloendopeptidase inhibitor activity||RECK; WFIKKN1; TIMP2; SPOCK3; TIMP2A; LXN; BST2; TIMP2B; WFIKKN2; TIMP4|
|protease binding||TTN; FURIN; ADAMTS4; CRADD; TIMP2A; HSPD1; SERPINA1; FN1; ITGA3; UBC|
|protein binding||NLRC4; RGP1; PHF16; EID1; RBM15B; THOP1; IFT46; RPS6KA2; CEP72; KLKB1|
timp1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with timp1 here. Most of them are supplied by our site. Hope this information will be useful for your research of timp1.
CD63; MMP9; RECQL5; EEF1B2; SUMO2; ECH1