TIMP3

  • Official Full Name

    TIMP metallopeptidase inhibitor 3

  • Overview

    This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix (ECM). Expression of this gene is induced in response to mitogenic stimulation and this netrin domain-containing protein is localized to the ECM. Mutations in this gene have been associated with the autosomal dominant disorder Sorsbys fundus dystrophy. [provided by RefSeq, Jul 2008]
  • Synonyms

    TIMP3; TIMP metallopeptidase inhibitor 3; SFD; K222; K222TA2; HSMRK222; metalloproteinase inhibitor 3; TIMP-3; MIG-5 protein; protein MIG-5; tissue inhibitor of metalloproteinases 3;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Cattle
  • Chicken
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • CHO
  • E.coli
  • HEK293
  • Mammalian Cell
  • Mammalian cells
  • Fc
  • His
  • His (Fc)
  • Avi
  • His|T7
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TIMP3-001H Active Recombinant Human TIMP3, MIgG2a Fc-tagged CHO Fc
Human TIMP3-002H Active Recombinant Human TIMP3 protein, Fc-tagged HEK293 Fc Cys24-Pro211
Human TIMP3-545H Recombinant Human TIMP3 protein, His & T7-tagged E.coli His/T7 Cys26~Pro211 (Accession # P35625)
Human TIMP3-852H Recombinant Human TIMP3 protein, His-tagged E.coli His
Human TIMP3-31151TH Recombinant Human TIMP3 N/A
Human TIMP3-2528H Recombinant Human TIMP Metallopeptidase Inhibitor 3 Mammalian cells N/A
Human TIMP3-2529H Recombinant Human TIMP Metallopeptidase Inhibitor 3, GST-tagged E.coli His 1-211aa
Human TIMP3-1064HCL Recombinant Human TIMP3 293 Cell Lysate HEK293 N/A
Human TIMP3-4492H-B Recombinant Human TIMP3 Protein Pre-coupled Magnetic Beads HEK293
Human TIMP3-412H Recombinant Human TIMP3 Protein, His-tagged E.coli N-His Cys26-Pro211
Human TIMP3-4492H Recombinant Human TIMP3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human TIMP3-2394H Recombinant Human TIMP3 Protein (Cys24-Pro211), His tagged E.coli His Cys24-Pro211
Mouse Timp3-546M Recombinant Mouse Timp3 protein, His-tagged E.coli His Gly20~Pro211
Mouse TIMP3-16800M Recombinant Mouse TIMP3 Protein Mammalian Cell His
Mouse TIMP3-9226M-B Recombinant Mouse TIMP3 Protein Pre-coupled Magnetic Beads HEK293
Mouse TIMP3-9226M Recombinant Mouse TIMP3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Timp3-547R Recombinant Rat Timp3 protein, His-tagged E.coli His Ser27~Thr209 (Accession # P48032)
Cattle TIMP3-544C Recombinant Cattle TIMP3 protein, His & T7-tagged E.coli His/T7 Pro31~Thr209 (Accession # P79121)
Cattle TIMP3-1271C Recombinant Cattle TIMP3 protein, His-GST-tagged E.coli His Cys24~Pro211
Cynomolgus Monkey TIMP3-1024C Recombinant Cynomolgus TIMP3 Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey TIMP3-767C Recombinant Cynomolgus Monkey TIMP3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey TIMP3-767C-B Recombinant Cynomolgus Monkey TIMP3 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque TIMP3-4723R Recombinant Rhesus monkey TIMP3 Protein, His-tagged Mammalian Cell His
Rhesus Macaque TIMP3-4537R-B Recombinant Rhesus Macaque TIMP3 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque TIMP3-4537R Recombinant Rhesus Macaque TIMP3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chicken TIMP3-7036C Recombinant Chicken TIMP3 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • TIMP3 Related Articles
  • TIMP3 Related Research Area

TIMP3 involved in several pathways and played different roles in them. We selected most pathways TIMP3 participated on our site, such as Proteoglycans in cancer, MicroRNAs in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with TIMP3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Proteoglycans in cancerFASLG;PRKACA;COL21A1;WNT5B;CAMK2D;HSPG2;PRKCA;GRB2;RPS6
MicroRNAs in cancerMDM2;CDC25A;DDIT4;BMPR2;SLC45A3;ERBB3;NOTCH2;STAT3;PLCG1

TIMP3 has several biochemical functions, for example, metal ion binding, metalloendopeptidase inhibitor activity, protease binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TIMP3 itself. We selected most functions TIMP3 had, and list some proteins which have the same functions with TIMP3. You can find most of the proteins on our site.

Function Related Protein
metal ion bindingZC3H7A;USP19;NUDT10;NRXN2;DNAJC21;CSHL1;NDUFS8;NEK10;XPA
metalloendopeptidase inhibitor activityTIMP4;COL4A3;RECK;NGF;TIMP3;SPOCK3;LXN;FETUB;SPOCK1
protease bindingSERPINB3;INS2;BCL2;FLOT2;LCN2;VWF;SEMG2;SERPINA5;SERPINB9
protein bindingTRIM29;JAK2;C1QTNF9B-AS1;HELZ;RACGAP1;CHRNB2;ZC3H8;CCDC9;TBC1D5

TIMP3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TIMP3 here. Most of them are supplied by our site. Hope this information will be useful for your research of TIMP3.

AGTR2; ADAMTS5

Jackson, MT; Moradi, B; et al. Activation of Matrix Metalloproteinases 2, 9, and 13 by Activated Protein C in Human Osteoarthritic Cartilage Chondrocytes. ARTHRITIS & RHEUMATOLOGY 66:1525-1536(2014).
Weizman, A; Huang, B; et al. Clinical, Serologic, and Genetic Factors Associated with Pyoderma Gangrenosum and Erythema Nodosum in Inflammatory Bowel Disease Patients. INFLAMMATORY BOWEL DISEASES 20:525-533(2014).
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Customer Reviews (3)

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Reviews
09/05/2019

    Manufacturers might offer customization options, such as different variants or modifications of the TIMP3 protein, to cater to specific research requirements.

    01/28/2018

      Such support helps researchers overcome challenges and obtain reliable results.

      06/06/2016

        This flexibility allows researchers to focus on specific aspects of TIMP3 protein functionality, regulation, or disease associations, enhancing the relevance and applicability of their work.

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