timp2

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timp2

Official Full Name TIMP metallopeptidase inhibitor 2
Background This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix. [provided by RefSeq, Jul 2008]
Synonyms TIMP2; TIMP metallopeptidase inhibitor 2; DDC8; CSC-21K; metalloproteinase inhibitor 2; TIMP-2; tissue inhibitor of metalloproteinase 2; tissue inhibitor of metalloproteinases 2;
    • Species :
    • Cattle
    • Chicken
    • Dog
    • Horse
    • Human
    • Mouse
    • Rat
    • Source :
    • CHO
    • E.coli
    • HEK293
    • HEK293F
    • HEK293T
    • Human
    • Human Cell
    • Human Fibroblasts
    • Insect Cell
    • Mammalian Cell
    • NS0
    • Sf9 Insect Cell
    • Tag :
    • Fc
    • His
    • T7
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human TIMP2-001H Recombinant Human TIMP2, MIgG2a Fc-tagged CHO Fc
    Human TIMP2-002H Recombinant Human TIMP2, HIgG1 Fc-tagged CHO Fc
    Human TIMP2-1027H Recombinant Human TIMP2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human TIMP2-152H Recombinant Human TIMP2 protein, T7/His-tagged E.coli T7/His
    Human TIMP2-15H Recombinant Human TIMP2, His-tagged E.coli His
    Human TIMP2-2061HCL Recombinant Human TIMP2 cell lysate Human Cell N/A
    Human TIMP2-2529H Recombinant Human TIMP Metallopeptidase Inhibitor 2 CHO N/A
    Human TIMP2-2887H Recombinant Human TIMP Metallopeptidase Inhibitor 2 Sf9 Insect Cell N/A
    Human TIMP2-29289TH Recombinant Human TIMP2 protein E.coli N/A
    Human TIMP2-37H Recombinant Human TIMP2 Protein, His-tagged Insect Cell His
    Human TIMP2-3835H Recombinant Human TIMP2, None tagged Human Cell N/A
    Human TIMP2-448H Recombinant Human TIMP2 protein, His-tagged HEK293F His
    Human TIMP2-5141H Recombinant Human TIMP Metallopeptidase Inhibitor 2 Human N/A
    Human TIMP2-603H Recombinant Human TIMP2 Protein, His-tagged HEK293 His
    Human TIMP2-604H Recombinant Human TIMP2 Protein, His-tagged HEK293 His
    Human TIMP2-8460H Native Human TIMP2 Human Fibroblasts N/A
    Human TIMP2-880H Recombinant Human TIMP2, Fc tagged Human Cell Fc
    Human TIMP2-881H Recombinant Human TIMP2 protein, His-tagged HEK293 His
    Mouse Timp2-542M Recombinant Mouse Timp2 protein, His-tagged E.coli His
    Mouse Timp2-6437M Recombinant Mouse Timp2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse Timp2-660M Recombinant Mouse Timp2 NS0 N/A
    Rat Timp2-543R Recombinant Rat Timp2 protein, His-tagged E.coli His
    Rat TIMP2-6077R Recombinant Rat TIMP2 Protein Mammalian Cell His
    Dog TIMP2-540D Recombinant Dog TIMP2 protein, His-tagged E.coli His
    Chicken TIMP2-5871C Recombinant Chicken TIMP2 Mammalian Cell His
    Cattle TIMP2-539C Recombinant Cattle TIMP2 protein, His & T7-tagged E.coli His/T7
    Horse TIMP2-541H Recombinant Horse TIMP2 protein, His-tagged E.coli His

    timp2 involved in several pathways and played different roles in them. We selected most pathways timp2 participated on our site, such as Activation of Matrix Metalloproteinases, Angiogenesis, Degradation of the extracellular matrix, which may be useful for your reference. Also, other proteins which involved in the same pathway with timp2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Activation of Matrix Metalloproteinases MMP8; CTSG; CTRB1; CTSLL; MMP10; CTSL2; MGC174152; CTSK; FURINA; MGC174857
    Angiogenesis CREBBP; TIMP2
    Degradation of the extracellular matrix CTRB1; CTS7; MGC174857; MMP20; FAM49BA; COL9A1; MMP15; CTSLL; COL15A1B; TIMP2
    Extracellular matrix organization COL8A1; COL10A1; PCOLCEB; BGNB; PTPRS; CTSLL; EFEMP2; EFEMP1; COL13A1; HAPLN1
    Matrix Metalloproteinases MMP20; TIMP2; TIMP4; MMP28; MMP24; MMP19; MMP10; MMP27; MMP25; BSG

    timp2 has several biochemical functions, for example, enzyme activator activity, integrin binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by timp2 itself. We selected most functions timp2 had, and list some proteins which have the same functions with timp2. You can find most of the proteins on our site.

    Function Related Protein
    enzyme activator activity SAE1; SEC14L2; GM1679; RICTOR; GMFB; ASAP2; RAB3GAP2; SFTPBB; TIMP2; PSAPL1
    integrin binding LAMA5; SYK; PXN; FCER2; TSPAN4; ANGPTL3; LYN; DST; ADAM15; ICAM2
    metal ion binding THAP7; ACVR1C; CELA1; DNAJA3B; ZDHHC15B; DNAJC21; HAND2; CAR7; RASSF5; ZFP27
    metalloendopeptidase inhibitor activity TIMP2; RECK; TIMP1; COL4A3; BST2; TIMP3; LXN; TIMP2B; TIMP2A; WFIKKN2
    protease binding ITGB3; ELANE; CNTNAP2; DVL3; FURIN; PYCARD; HSPA6; TIMP2; TIMP2B; FLOT1
    protein binding RAB11FIP2; RAMP3; STXBP4; ZCCHC17; SCFD1; UNC45B; RGMA; ARL14; FAM81B; GTF2H4

    timp2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with timp2 here. Most of them are supplied by our site. Hope this information will be useful for your research of timp2.

    MMP2; 51464480; PGRMC1; PSMA7; SNCG; HSPA4L; APC2; RAB3A; PCMT1; PAICS; ECHS1; RANBP1; RPL29; MMP14; NPEPPS; PSMA6; PSME3; GANAB; NUDC

    Bennett, RG; Heimann, DG; et al. Relaxin decreases the severity of established hepatic fibrosis in mice. LIVER INTERNATIONAL 34:416-426(2014).
    Albert, CR; Schlesinger, WJ; et al. Effect of Hydroxychloroquine on Antiphospholipid Antibody-Induced Changes in First Trimester Trophoblast Function. AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY 71:154-164(2014).

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