TIMP2
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Official Full Name
TIMP metallopeptidase inhibitor 2
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Overview
This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix. [provided by RefSeq, Jul 2008] -
Synonyms
TIMP2; TIMP metallopeptidase inhibitor 2; DDC8; CSC-21K; metalloproteinase inhibitor 2; TIMP-2; tissue inhibitor of metalloproteinase 2; tissue inhibitor of metalloproteinases 2;
- Recombinant Proteins
- Cell & Tissue Lysates
- Native Proteins
- Protein Pre-coupled Magnetic Beads
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- Sf9 Insect Cell
- Fc
- GST
- His
- Avi
- Myc
- T7
- DDK
- Non
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
TIMP2 involved in several pathways and played different roles in them. We selected most pathways TIMP2 participated on our site, such as Activation of Matrix Metalloproteinases, Angiogenesis, Degradation of the extracellular matrix, which may be useful for your reference. Also, other proteins which involved in the same pathway with TIMP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Activation of Matrix Metalloproteinases | MGC174152;MMP13;LOC100686744;FURINB;TIMP2A;CMA1;CTSL2;CTSLL;CTSG |
| Angiogenesis | TIMP2;CREBBP |
| Degradation of the extracellular matrix | TIMP2A;MGC174155;COL9A3;CTSG;CTSS;ADAM8A;MMP13;MMP17;ADAM15 |
| Extracellular matrix organization | ADAMTS5;COL6A2;COL10A1;ELANE;FURINB;LEPREL1;PTPRS;ICAM4;MFAP4 |
| Matrix Metalloproteinases | MMP11;MMP24;MMP10;MMP28;MMP8;MMP15;MMP23B;MMP27;MMP19 |
TIMP2 has several biochemical functions, for example, enzyme activator activity, integrin binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TIMP2 itself. We selected most functions TIMP2 had, and list some proteins which have the same functions with TIMP2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| enzyme activator activity | DNMT3L;CASP9;DCP1B;MMP15;CFLAR;TAB1;OGT;RAB3GAP2;CTAGE5 |
| integrin binding | FCER2;LYN;DST;FBLN1;S1PR3;ADAM15;EDIL3;MFGE8;L1CAM |
| metal ion binding | KLF11;PPP4CA;B3GAT1;ADARB1;ZFP488;GIT2B;ZKSCAN6;WBSCR17;THAP7 |
| metalloendopeptidase inhibitor activity | TIMP2A;BST2;TIMP2B;COL4A3;LXN;WFIKKN2;NGF;TIMP3;SPOCK3 |
| protease binding | PYCARD;CHL1;SERPINA1A;BCL2;FLOT1;SEMG2;ADRM1;TIMP1;UBC |
| protein binding | GATA4;S100A1;RBBP8;CD79A;SNX8;PLDN;DHX30;EDC3;PTGDR |
TIMP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TIMP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TIMP2.
MMP2; 51464480; PGRMC1; PSMA7; SNCG; HSPA4L; APC2; RAB3A; PCMT1; PAICS; ECHS1; RANBP1; RPL29; MMP14; NPEPPS; PSMA6; PSME3; GANAB; NUDC
Research Area
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