TIMP2

  • Official Full Name

    TIMP metallopeptidase inhibitor 2

  • Overview

    This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix. [provided by RefSeq, Jul 2008]
  • Synonyms

    TIMP2; TIMP metallopeptidase inhibitor 2; DDC8; CSC-21K; metalloproteinase inhibitor 2; TIMP-2; tissue inhibitor of metalloproteinase 2; tissue inhibitor of metalloproteinases 2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Native Proteins
  • Protein Pre-coupled Magnetic Beads
  • Cattle
  • Chicken
  • Dog
  • Horse
  • Human
  • Mouse
  • Rat
  • CHO
  • E.coli
  • HEK293
  • HEK293F
  • HEK293T
  • Human
  • Human Cell
  • Human Fibroblasts
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Sf9 Insect Cell
  • C
  • His
  • Fc
  • GST
  • hFc
  • His (Fc)
  • Avi
  • Myc
  • His|T7
  • DDK
  • Myc|DDK
  • N/A
  • N
  • T7|His
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TIMP2-3835H Active Recombinant Human TIMP2 protein(Cys27-Pro220) HEK293 N/A Cys27-Pro220
Human TIMP2-001H Active Recombinant Human TIMP2, MIgG2a Fc-tagged CHO Fc
Human TIMP2-002H Active Recombinant Human TIMP2, HIgG1 Fc-tagged CHO Fc
Human TIMP2-448H Recombinant Human TIMP2 protein, His-tagged HEK293F His Cys27~Pro220
Human TIMP2-2529H Recombinant Human TIMP Metallopeptidase Inhibitor 2 CHO N/A
Human TIMP2-5141H Recombinant Human TIMP Metallopeptidase Inhibitor 2 Human N/A
Human TIMP2-881H Recombinant Human TIMP2 protein, His-tagged HEK293 His 194
Human TIMP2-880H Recombinant Human TIMP2 protein, hFc-tagged HEK293 hFc Cys27-Pro220
Human TIMP2-2887H Recombinant Human TIMP Metallopeptidase Inhibitor 2 Sf9 Insect Cell N/A
Human TIMP2-604H Recombinant Human TIMP2 protein, His-tagged HEK293 His Cys 27 - Pro 220
Human TIMP2-15H Recombinant Human TIMP2, His-tagged E.coli His 27-220aa
Human TIMP2-29289TH Recombinant Human TIMP2 protein E.coli N/A 194
Human TIMP2-37H Recombinant Human TIMP2 Protein, His-tagged Insect Cell His
Human TIMP2-603H Recombinant Human TIMP2 Protein, His-tagged HEK293 His
Human TIMP2-152H Recombinant Human TIMP2 protein, T7/His-tagged E.coli T7/His
Human TIMP2-2061HCL Recombinant Human TIMP2 cell lysate Human Cell N/A
Human TIMP2-5237H Recombinant Human TIMP2 protein, GST-tagged E.coli GST 30-220aa
Human TIMP2-1027H Recombinant Human TIMP2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human TIMP2-3399H Recombinant Human TIMP2 protein, His-GST-tagged E.coli His/GST Cys27~Pro220
Human TIMP2-6457H Recombinant Human TIMP2 Protein (Cys27-Pro220), C-His tagged Mammalian cells C-His Cys27-Pro220
Human TIMP2-1475H Recombinant Human TIMP2 protein, His-Myc-tagged HEK293 His/Myc 27-220aa
Human TIMP2-8460H Native Human TIMP2 Human Fibroblasts N/A
Mouse Timp2-660M Active Recombinant Mouse Timp2 Mammalian cells N/A Met1-Pro220
Mouse Timp2-542M Recombinant Mouse Timp2 protein, His-tagged E.coli His Cys27~Pro220
Mouse Timp2-10621M-B Recombinant Mouse Timp2 Protein Pre-coupled Magnetic Beads HEK293
Mouse Timp2-10621M Recombinant Mouse Timp2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Timp2-6437M Recombinant Mouse Timp2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat Timp2-543R Recombinant Rat Timp2 protein, His-tagged E.coli His Cys27~Pro220 (Accession # P30121)
Rat TIMP2-6077R Recombinant Rat TIMP2 Protein Mammalian Cell His
Rat TIMP2-5734R Recombinant Rat TIMP2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat TIMP2-5734R-B Recombinant Rat TIMP2 Protein Pre-coupled Magnetic Beads HEK293
Dog TIMP2-540D Recombinant Dog TIMP2 protein, His-tagged E.coli His His33~Glu153 (Accession # Q9TTY1)
Cattle TIMP2-539C Recombinant Cattle TIMP2 protein, His & T7-tagged E.coli His/T7 Cys27~Pro220 (Accession # P16368)
Horse TIMP2-541H Recombinant Horse TIMP2 protein, His-tagged E.coli His Ala2~Thr88 (Accession # O77717)
Chicken TIMP2-5871C Recombinant Chicken TIMP2 Mammalian Cell His
Chicken TIMP2-411C Recombinant Chicken TIMP2 Protein, His-tagged E.coli N-His Cys27-Pro220
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

TIMP2 involved in several pathways and played different roles in them. We selected most pathways TIMP2 participated on our site, such as Activation of Matrix Metalloproteinases, Angiogenesis, Degradation of the extracellular matrix, which may be useful for your reference. Also, other proteins which involved in the same pathway with TIMP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Activation of Matrix MetalloproteinasesMMP24;TIMP2A;FURINB;MMP10;MGC174155;TPSAB1;CTSK;CTSG;TIMP2
AngiogenesisCREBBP;TIMP2
Degradation of the extracellular matrixMGC174155;TLDC2;BMP1A;ADAMTS18;CTSG;CMA1;ADAMTS1;MMP24;MMP10
Extracellular matrix organizationCAPNS1;ICAM4;COL2A1;CTSD;FURINB;FBLN1;SERPINH1B;MMP24;ITGB3A
Matrix MetalloproteinasesMMP26;MMP10;MMP11;MMP19;MMP23B;MMP12;MMP17;TIMP4;TIMP2

TIMP2 has several biochemical functions, for example, enzyme activator activity, integrin binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TIMP2 itself. We selected most functions TIMP2 had, and list some proteins which have the same functions with TIMP2. You can find most of the proteins on our site.

Function Related Protein
enzyme activator activityAPOA5;MMP15;CLPSL1;MMP16;RAB3GAP2;PRKCE;PSAP;TRIM23;ARL1
integrin bindingANXA7;S1PR2;IGF1;ITGA5;ICAM3;ADAM23;SRC;ICAM2;ANGPTL3
metal ion bindingU2AF1L4;SMAD2;ARAF;SETDB1B;BMPR1B;FGD4;ACMSD;ZNF404;LHX8A
metalloendopeptidase inhibitor activityRECK;WFIKKN1;SPOCK3;TIMP4;FETUB;SPOCK1;TIMP3;WFIKKN2;TIMP2
protease bindingBCL2;TNFAIP3;TRP53;FN1;OS9;LDLR;Cstb;SERPINE1;CFLAR
protein bindingBLMH;DCTN3;ERN1;ASXL1;RUFY1;ARL6IP1;MET;PAX5;S100A11

TIMP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TIMP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TIMP2.

MMP2; 51464480; PGRMC1; PSMA7; SNCG; HSPA4L; APC2; RAB3A; PCMT1; PAICS; ECHS1; RANBP1; RPL29; MMP14; NPEPPS; PSMA6; PSME3; GANAB; NUDC

Research Area

Related articles

Bennett, RG; Heimann, DG; et al. Relaxin decreases the severity of established hepatic fibrosis in mice. LIVER INTERNATIONAL 34:416-426(2014).
Albert, CR; Schlesinger, WJ; et al. Effect of Hydroxychloroquine on Antiphospholipid Antibody-Induced Changes in First Trimester Trophoblast Function. AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY 71:154-164(2014).
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