"FCGR2A" Related Products


Recombinant Human FCGR2A, His-tagged

Cat.No.: FCGR2A-399H
Product Overview: A DNA sequence encoding ( Met 1-Ile 218) of human CD32a (NP_001129691.1) was expressed with a C-terminal polyhistidine tag.
Description: Receptors that recognize the Fc portion of IgG (Fcγ Rs) functions in the regulation of immune response and are divided into three classes designated Fcγ RI (CD64), Fcγ RII (CD32), and Fcγ RIII (CD16). Fcγ RI binds IgG with high affinity and functions during early immune responses, whereas Fcγ RII and RIII are low affinity receptors that recognize IgG as aggregates surrounding multivalent antigens during late immune responses. Human CD32 class is encoded by three closely related genes, and designated Fcγ RII A, B, and C which share 94 - 99% amino acid identity in their extracellular domains but differ substantially in their transmembrane and cytoplasmic domains. Fcγ RII A is expressed on cells of both myeloid and lymphoid lineages as well as on cells of non-hematopoietic origin. Associated with an ITAM (immunoreceptor tyrosine-based activation motif)- bearing adapter subunit, Fc Rγ, CD32a (Fcγ RII A) delivers an activating signal upon ligand binding, and results in the initiation of inflammatory responses including cytolysis, phagocytosis, degranulation and cytokine production. The responses can be modulated by signals from the coexpressed inhibitory receptors such as Fcγ RII B, and the strength of the signal is dependent on the ratio of expression of the activating and inhibitory receptors.
Source: CHO Cells
Species: Human
Tag: His
Predicted N Terminal: Gln 34
Form: Lyophilized from sterile PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements.
Molecular Mass: The secreted recombinant human CD32a consists of 196 amino acids and predicts a molecular mass of 22 KDa. The apparent molecular mass of the protein is approximately 29-32 KDa in SDS-PAGE under reducing conditions due to glycosylation.
Endotoxin: < 1.0 eu per μg of the protein as determined by the lal
Purity: >95 % as determined by SDS-PAGE
Stability: Samples are stable for up to twelve months from date of receipt at -70℃
Storage: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Gene Name: FCGR2A?Fc fragment of IgG, low affinity IIa, receptor (CD32) [?Homo sapiens?(human) ]
Official Symbol: FCGR2A
Synonyms: FCGR2A; CD32; FCG2; FcGR; CD32A; CDw32; FCGR2; IGFR2; FCGR2A1; Fc fragment of IgG, low affinity IIa, receptor (CD32); low affinity immunoglobulin gamma Fc region receptor II-a; fcRII-a; fc-gamma-RIIa; fc-gamma RII-a; igG Fc receptor II-a; Immunoglobulin G
Gene ID: 2212
mRNA Refseq: NM_001136219
Protein Refseq: NP_001129691
MIM: 146790
UniProt ID: P12318
Chromosome Location: 1q23
Pathway: FCGR activation; Fc gamma R-mediated phagocytosis; Fcgamma receptor (FCGR) dependent phagocytosis
Function: IgG binding

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