Recombinant Human CHRNA6, His-tagged

• Cat.No.: CHRNA6-68H
• Product Overview: Recombinant Human Neuronal Acetylcholine Receptor Subunit α-6/CHRNA6 is produced by our mammalian expression system in human cells. The target protein is expressed with sequence (His328-Arg465) of Human CHRNA6 fused with a polyhistidine tag at the C-terminus.

Specification

• Source: HEK293
• Species: Human
• Tag: His
• AA Sequence: EPSPGTLPRKAGVFSDLSNQELKAV HSFLWSKKELRLQPSSTTTMAKNTV FLIEMLLPKKYHVLR FLDKGERHPVREARAVIFFGDQEHP NVTEFAVGPLPGPCYMRALSPRPGY QSSWASRPISTAEYA LLYHTLQEATKPLHQFFLNTTGFSF QDCHDRCLAFTDVAPRGVASGQRRS WLIIQRYVEGYFLHP TGLELLVDHGSTDAGHWAVEQVWYN GKFYGSPEELARKYADGEVDVVVLE DPLPGGKGHDSTEEP PLFSSHKPRGDFPSPIHVSGPRLVQ PHGPRFRLEGNAVLYGGWSFAFRLR SSSGLQVLNVHFGGE RIAYEVSVQEAVALYGGHTPAGMQT KYLDVGWGLGSVTHELAPGIDCPET ATFLDTFHYYDADDP VHYPRALCLFEMPTGVPLRRHFNSN FKGGFNFYAGLKGQVLVLRTTSTVY NYDYIWDFIFYPNGV MEAKMHATGYVHATFYTPEGLRHGT RLHTHLIGNIHTHLVHYRVDLDVAG TKNSFQTLQMKLENI TNPWSPRHRVVQPTLEQTQYSWERQ AAFRFKRKLPKYLLFTSPQENPWGH KRSYRLQIHSMADQV LPPGWQEEQAITWARYPLAVTKYRE SELCSSSIYHQNDPWDPPVVFEQFL HNNENIENEDLVAWV TVGFLHIPHSEDIPNTATPGNSVGF LLRPFNFFPEDPSLASRDTVIVWPR DNGPNYVQRWIPEDR DCSMPPPFSYNGTYRPVVDHHHHHH
• Endotoxin: Less than 0.1 ng/μg (1 IEU/μg).
• Purity: Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE.

Gene Information

• Gene Name: CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal) [ Homo sapiens ]
• Official Symbol: CHRNA6
• Synonyms: CHRNA6; cholinergic receptor, nicotinic, alpha 6 (neuronal); cholinergic receptor, nicotinic, alpha polypeptide 6; neuronal acetylcholine receptor subunit alpha-6; acetylcholine receptor; nicotinic; alpha 6 (neuronal); acetylcholine receptor, nicotinic, alpha 6 (neuronal); CHNRA6
• Gene ID: 8973
• mRNA Refseq: NM_001199279
• Protein Refseq: NP_001186208
• MIM: 606888
• UniProt ID: Q15825
• Chromosome Location: 8p22
• Pathway: Acetylcholine Binding And Downstream Events, organism-specific biosystem; Activation of Nicotinic Acetylcholine Receptors, organism-specific biosystem; Cholinergic synapse, organism-specific biosystem; Highly calcium permeable nicotinic acetylcholine receptors, organism-specific biosystem; Highly calcium permeable postsynaptic nicotinic acetylcholine receptors, organism-specific biosystem; Neuroactive ligand-receptor interaction, organism-specific biosystem; Neuroactive ligand-receptor interaction, conserved biosystem
• Function: acetylcholine receptor activity; acetylcholine-activated cation-selective channel activity; extracellular ligand-gated ion channel activity; ion channel activity; receptor activity