CHRNA7

  • Official Full Name

    cholinergic receptor, nicotinic, alpha 7 (neuronal)
  • Overview

    The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits. The proposed structure for each subunit is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. The protein encoded by this gene forms a homo-oligomeric channel, displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by, and highly sensitive to, alpha-bungarotoxin. Once this receptor binds acetylcholine, it undergoes an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. This gene is located in a region identified as a major susceptibility locus for juvenile myoclonic epilepsy and a chromosomal location involved in the genetic transmission of schizophrenia. An evolutionarily recent partial duplication event in this region results in a hybrid containing sequence from this gene and a novel FAM7A gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]
  • Synonyms

    CHRNA7;cholinergic receptor, nicotinic, alpha 7 (neuronal);NACHRA7;CHRNA7-2;neuronal acetylcholine receptor subunit alpha-7;a7 nicotinic acetylcholine receptor;alpha-7 nicotinic cholinergic receptor subunit;alpha 7 neuronal nicotinic acetylcholine receptor;cholinergic receptor, nicotinic, alpha polypeptide 7;neuronal acetylcholine receptor protein, alpha-7 chain

Recombinant Proteins

  • Human
  • Zebrafish
  • Rat
  • Mouse
  • Chicken
  • Rhesus macaque
  • E.coli
  • Mammalian Cells
  • Wheat Germ
  • HEK293
  • In Vitro Cell Free System
  • GST
  • His
  • Non
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
CHRNA7-526H Recombinant Human CHRNA7 protein, His-GST-tagged E.coli Human GST&His Gly23~Thr230
CHRNA7-11431Z Recombinant Zebrafish CHRNA7 Mammalian Cells Zebrafish His
CHRNA7-1283H Recombinant Human CHRNA7 Protein, GST-Tagged Wheat Germ Human GST
CHRNA7-1394R Recombinant Rat CHRNA7 Protein Mammalian Cells Rat His
CHRNA7-177H Recombinant Human CHRNA7 Mammalian Cells Human His
CHRNA7-3436M Recombinant Mouse CHRNA7 Protein Mammalian Cells Mouse His
CHRNA7-5755C Recombinant Chicken CHRNA7 Mammalian Cells Chicken His
CHRNA7-863R Recombinant Rhesus monkey CHRNA7 Protein, His-tagged Mammalian Cells Rhesus macaque His
CHRNA7-7514HCL Recombinant Human CHRNA7 293 Cell Lysate HEK293 Human Non
CHRNA7-1052R Recombinant Rat CHRNA7 Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
CHRNA7-1052R-B Recombinant Rat CHRNA7 Protein Pre-coupled Magnetic Beads HEK293 Rat
CHRNA7-1667M Recombinant Mouse CHRNA7 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
CHRNA7-1667M-B Recombinant Mouse CHRNA7 Protein Pre-coupled Magnetic Beads HEK293 Mouse
CHRNA7-1726H Recombinant Human CHRNA7 Protein (Arg118-Tyr227), N-His tagged E.coli Human His Arg118-Tyr227
CHRNA7-2674H Recombinant Human CHRNA7 Protein, His (Fc)-Avi-tagged HEK293 Human Avi&Fc&His
CHRNA7-2674H-B Recombinant Human CHRNA7 Protein Pre-coupled Magnetic Beads HEK293 Human
CHRNa7-3216R Recombinant Rat CHRNa7 protein, His-tagged E.coli Rat His Gly23~Thr230
CHRNA7-3240HF Recombinant Full Length Human CHRNA7 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 321 amino acids
CHRNA7-527H Recombinant Human CHRNA7 Protein, His/GST-tagged E.coli Human GST&His Gly23~Ala502
CHRNA7-6875H Recombinant Human CHRNA7 protein, His-tagged E.coli Human His 130-321 aa
CHRNA7-689R Recombinant Rhesus Macaque CHRNA7 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque Avi&Fc&His
CHRNA7-689R-B Recombinant Rhesus Macaque CHRNA7 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque

    Involved Pathway

    CHRNA7 involved in several pathways and played different roles in them. We selected most pathways CHRNA7 participated on our site, such as Acetylcholine Binding And Downstream Events,Activation of Nicotinic Acetylcholine Receptors,Calcium signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CHRNA7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Chemical carcinogenesis GSTM6,ALDH3A1,UGT1A6A,CYP1B1,CYP3A41B,ADH1C,MGST3,GSTP1,Nat3,GSTM4
    Neuronal System CCDC167,KCNMA1,SLC6A1A,CHRNA1,PPFIA1,GJC1,Apba1,PICK1,GJA10,KCNJ1A.4
    Cholinergic synapse KCNJ3,FYN,CHRNB4,GNAO1,ATF4,CREB3,SLC5A7,CREB3L2,MAPK1,GNAI2
    Calcium signaling pathway CALM,NOS2B,ADRB3,TACR3A,ADCY1A,PLCD1,PPP3CA,PTK2BB,CAMK2D1,CACNA1H
    Acetylcholine Binding And Downstream Events CHRNA5,CHRND,CHRNA2,CHRNA3,CHRNB4,CHRNA4,CHRNB2,CHRNE,CHRNA1
    Activation of Nicotinic Acetylcholine Receptors CHRNA2,CHRNA1,CHRNB2,CHRND,CHRNA5,CHRNA4,CHRNB4,CHRNE,CHRNA3
    Neuroactive ligand-receptor interaction THRA,PTGER4A,P2RY6,NPFFR2,PTGER2,GRIN2D,HRH2,GABRQ,TRY,HTR1F
    Highly calcium permeable postsynaptic nicotinic acetylcholine receptors CHRNA3,CHRNA1,CHRNB4,CHRNA4,CHRNA2,CHRNB2,CHRNA5

    Protein Function

    CHRNA7 has several biochemical functions, for example, ATPase binding,acetylcholine binding,acetylcholine receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CHRNA7 itself. We selected most functions CHRNA7 had, and list some proteins which have the same functions with CHRNA7. You can find most of the proteins on our site.

    Function Related Protein
    protein kinase binding CHEK2,CRY1,TCF7L2,CCNL1,FAM83A,RACGAP1,PPP1CB,PTK2,SCN5A,CALM1
    acetylcholine-activated cation-selective channel activity CHRNA1,CHRNA6,CHRNA2A,CHRNA3,CHRNB4,CHRNA10A,CHRNA2,CHRNB2,Chrng,CHRNA4B
    adenylate cyclase binding ADRB2,CALM2,ADCYAP1R1,CALM3,AKAP12,CALM1,AKAP6,AKAP5
    ATPase binding SYVN1,DERL1,ATP1B3,ATP6V0A1,NHP2L1,DNAJB1,FAM119A,NUFIP1,SNX10,ATP6V1G1
    toxic substance binding GUCY2C,ASS1,Alb,H2-AB1,PHAX,A4GALT,DSG1,NEFH,AZU1,EPHX2
    acetylcholine binding CHRNB1,ACHE,CHRNA3,CHRNA4,CHRFAM7A,CHRM3,CHRNB3,CHRNB2
    chloride channel regulator activity BSND,SGK1,SGK2A,SLC9A3R1,SGK3,SGK2B,SGK2
    acetylcholine receptor activity CHRNA6,CHRNE,CHRNA4,ANXA9,CHRNB2,CHRNA5,CHRNA2,CHRNA3,CHRNB4
    drug binding Alb,CHRNB2,DCK,ACE,DRD1A,FOLR2,HMGCS1,TLR7,ADH1,GABRA1

    Interacting Protein

    CHRNA7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CHRNA7 here. Most of them are supplied by our site. Hope this information will be useful for your research of CHRNA7.

    APP;APP;ATXN1

    Resources

    References

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