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Recombinant Mouse Grn

Cat.No. : Grn-467M
Product Overview : Signal peptide and mouse progranulin (aa 1-589) is untagged. Reflects the native sequence with no additional aa.
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Description : Progranulin (PGRN) is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of frontotemporal degeneration (FTLD). In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimer‘s Disease (AD) and potentially for MCI (Mild Cognitive Impairment). Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis.
Source : HEK293 Cells
Species : Mouse
Tag : N/A
Form : Lyophilized from 0.2μm-filtered solution in PBS, pH 7.2.
Molecular Mass : ~65kDa (SDS-PAGE)
Purity : Silver staining was used for visualization.
Stability : Working aliquots are stable for up to 3 months when stored at -20°C.
Storage : Short Term Storage: +4°C; Long Term Storage: -20°C. After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Gene Name : Grn granulin [ Mus musculus ]
Official Symbol : Grn
Synonyms : GRN; granulin; granulins; PEPI; PCDGF; progranulin; acrogranulin; proepithelin; PC cell-derived growth factor; epithelin;
Gene ID : 14824
mRNA Refseq : NM_008175
Protein Refseq : NP_032201

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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Are there have any relationship between GRN protein and TDP-43 protein? 11/04/2019

There is an interaction between GRN protein and TDP-43 protein, and together they are involved in the development of neurodegenerative diseases.

Why does GRN protein play a role in neuroprotection? 07/21/2019

GRN protein is involved in neuroprotection by regulating cell survival, apoptosis, inflammatory response and other pathways. It may work by promoting neuronal survival, suppressing inflammatory responses, and more.

What is the diagnostic significance of GRN protein in neurodegenerative diseases? 06/17/2019

Abnormal expression of GRN protein is related to neurodegenerative diseases, and detecting the expression level of GRN protein or gene mutation can help diagnose these diseases and provide reference for treatment and prognosis assessment.

What is the role of GRN protein in Alzheimer's disease? 05/05/2019

The role of GRN protein in Alzheimer's disease is not fully understood, but studies have shown that it is involved in the metabolism and clearance of β-amyloid, which may have an important impact on the pathological process.

Are there transcription factors involved in the regulation of GRN protein expression? 02/26/2019

Yes, some transcription factors have been found to regulate the expression of GRN proteins, including CREB, SMAD, etc.

Which role of GRN protein in prefrontal dementia? 02/08/2019

GRN protein plays an important role in prefrontal dementia. It is involved in the survival and maintenance of nerve cells, and its deletion or mutation may lead to degenerative loss of nerve cells.

Customer Reviews (3)

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Reviews
06/16/2022

    The outstanding quality of proteins lies in their strong biological activity and their high purity during production, which is really rare.

    04/30/2022

      Application of this protein enables researchers to conduct research in more fields and broadens the horizon of scientific research.

      06/29/2019

        This protein has a short half-life, high clearance rate, and high safety and efficacy.

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