grn

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grn

Official Full Name granulin
Background Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis.
Synonyms GRN; granulin; GEP; GP88; PEPI; PGRN; PCDGF; progranulin; Acrogranin; Granulin-1; Granulin G; Granulin-2; Granulin F; Granulin-3; Granulin-4; Granulin-5; Granulin-6; Granulin-7; Granulin A; Granulin C; Granulin D; Granulin E; granulin-epithelin; proepithelin; PC cell-derived growth factor
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Human Cell
    • Wheat Germ
    • Tag :
    • C-Myc/DDK
    • Flag
    • GST
    • His
    • S
    • T7
    • MYC/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human GRN-041H Recombinant Human GRN Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
    Human GRN-113H Recombinant Human Granulin, His-tagged E.coli His
    Human GRN-2358H Recombinant Human GRN Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human GRN-2379H Recombinant Human Granulin, FLAG-tagged Human Cell Flag
    Human GRN-26404TH Recombinant Human GRN, His-tagged E.coli His
    Human GRN-2791HCL Recombinant Human GRN cell lysate Human Cell N/A
    Human GRN-28163TH Recombinant Human GRN, FLAG-tagged HEK293 Flag
    Human GRN-4937H Recombinant Human Mitogen-Activated Protein Kinase 11 HEK293 N/A
    Human GRN-5375H Recombinant Human GRN Protein, GST-tagged Wheat Germ GST
    Human GRN-726H Recombinant Human GRN, His tagged Human Cell His
    Human GRN-7847H Recombinant Human GRN protein, His & S-tagged E.coli His/S
    Mouse Grn-1065M Recombinant Mouse Grn Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Mouse GRN-2412MCL Recombinant Mouse GRN cell lysate Human Cell N/A
    Mouse Grn-3287M Recombinant Mouse Grn, His tagged Human Cell His
    Mouse Grn-466M Recombinant Mouse Grn, FLAG-tagged HEK293 Flag
    Mouse Grn-467M Recombinant Mouse Grn HEK293 N/A
    Mouse Grn-7848M Recombinant Mouse Grn protein, His & T7-tagged E.coli His/T7
    Rat Grn-469R Recombinant Rat Grn, FLAG-tagged HEK293 Flag

    grn involved in several pathways and played different roles in them. We selected most pathways grn participated on our site, such as Integrated Breast Cancer Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with grn were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Integrated Breast Cancer Pathway EDAR; ZMIZ1; ERAL1; CYP19A1; JAKMIP1; MYT1; GDI1; CCNB1IP1; UBE2F; GRN

    grn has several biochemical functions, for example, cytokine activity, growth factor activity, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by grn itself. We selected most functions grn had, and list some proteins which have the same functions with grn. You can find most of the proteins on our site.

    Function Related Protein
    cytokine activity TNFSF10; BMP8B; IL4; IL17A/F3; BMP7B; LTA; LEFTY1; MIF; SPP1; SPAW
    growth factor activity HDGF; GDF1; TIMP1; FGF9; IGF1; BMP7; COL20A1; PRL2C2; IL4; FGF10
    poly(A) RNA binding FTSJ3; MRPL42; GNL3; HSD17B10; NOM1; UBFD1; PTRF; MRPL54; EIF5; HNRNPA1
    protein binding ZNF543; AIG1; NUDT18; PPP1R2P3; CRYBA2; APOBEC2B; MRPL51; ACD; DUSP5; KLRG1

    grn has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with grn here. Most of them are supplied by our site. Hope this information will be useful for your research of grn.

    GLRX3; HOXA1; TNFRSF1A; TNFRSF1B; 80125

    Igarashi, K; Ochiai, K; et al. Orchestration of plasma cell differentiation by Bach2 and its gene regulatory network. IMMUNOLOGICAL REVIEWS 261:116-125(2014).
    Evans, RL; Pottala, JV; et al. Classifying Patients for Breast Cancer by Detection of Autoantibodies against a Panel of Conformation-Carrying Antigens. CANCER PREVENTION RESEARCH 7:545-555(2014).

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