GRN

  • Official Full Name

    granulin

  • Overview

    Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis.
  • Synonyms

    GRN; granulin; GEP; GP88; PEPI; PGRN; PCDGF; progranulin; Acrogranin; Granulin-1; Granulin G; Granulin-2; Granulin F; Granulin-3; Granulin-4; Granulin-5; Granulin-6; Granulin-7; Granulin A; Granulin C; Granulin D; Granulin E; granulin-epithelin; proepithelin; PC cell-derived growth factor;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Baculovirus-Insect cells
  • E.coli
  • HEK293
  • HEK293T
  • Human Cell
  • In Vitro Cell Free System
  • Mammalian cells
  • Wheat Germ
  • C
  • His
  • Myc
  • DDK
  • Flag
  • GST
  • His (Fc)
  • Avi
  • His|S
  • His|T7
  • MYC
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human GRN-26404TH Recombinant Human GRN, His-tagged E.coli His
Human GRN-4937H Recombinant Human Mitogen-Activated Protein Kinase 11 HEK293 N/A
Human GRN-2379H Recombinant Human Granulin, FLAG-tagged Human Cell Flag
Human GRN-113H Recombinant Human Granulin, His-tagged E.coli His
Human GRN-28163TH Recombinant Human GRN, FLAG-tagged HEK293 Flag
Human GRN-726H Recombinant Human GRN protein, His-tagged HEK293 His
Human GRN-7847H Recombinant Human GRN protein, His & S-tagged E.coli His/S
Human GRN-2791HCL Recombinant Human GRN cell lysate Human Cell N/A
Human GRN-2358H Recombinant Human GRN Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human GRN-5599HF Recombinant Full Length Human GRN Protein, GST-tagged In Vitro Cell Free System GST
Human GRN-3063H Recombinant Human GRN Protein (Thr18-Asp363), N-His tagged E.coli N-His
Human GRN-5375H Recombinant Human GRN Protein, GST-tagged Wheat Germ GST
Human GRN-844HFL Recombinant Full Length Human GRN Protein, C-Flag-tagged Mammalian cells Flag
Human GRN-041H Recombinant Human GRN Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human GRN-1022H-B Recombinant Human GRN Protein Pre-coupled Magnetic Beads HEK293
Human GRN-1022H Recombinant Human GRN Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Grn-466M Active Recombinant Mouse Grn, FLAG-tagged HEK293 Flag
Mouse Grn-467M Recombinant Mouse Grn HEK293 N/A
Mouse Grn-3287M Recombinant Mouse Grn protein, His-tagged HEK293 His
Mouse Grn-7848M Recombinant Mouse Grn protein, His & T7-tagged E.coli His/T7
Mouse GRN-2412MCL Recombinant Mouse GRN cell lysate Human Cell N/A
Mouse Grn-1065M Recombinant Mouse Grn Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse Grn-0148M Recombinant Mouse Grn Protein (Met1-Leu589), C-His-tagged Baculovirus-Insect cells C-His
Rat Grn-469R Recombinant Rat Grn, FLAG-tagged HEK293 Flag
Rat Grn-1593R Recombinant Rat Grn Protein, His-tagged E.coli N-His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • GRN Related Articles
  • GRN Related Research Area

GRN involved in several pathways and played different roles in them. We selected most pathways GRN participated on our site, such as Integrated Breast Cancer Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Integrated Breast Cancer PathwayBACH1;MYT1;GRN;ERAL1;ALKBH1;DCAKD;CYP19A1;SELK;APOBEC3G

GRN has several biochemical functions, for example, cytokine activity, growth factor activity, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GRN itself. We selected most functions GRN had, and list some proteins which have the same functions with GRN. You can find most of the proteins on our site.

Function Related Protein
cytokine activitySCGB3A1;WNT2;IFNG;GM13285;LIF;TNFSF4;CD70;MSTNA;IL36B
growth factor activityFGF21;FGF10B;IL11;CXCL1;TGFB1A;F2;FGF11A;GDF9;FGF17
poly(A) RNA bindingRPL14;RPL29;QK;RPS19;TSNAX;NOC3L;H1FX;ASS1;HIST1H1E
protein bindingHTT;FZD6;STK10;PIK3R4;EPN2;AK8;UBE2F;GZMA;FKBP3

GRN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRN here. Most of them are supplied by our site. Hope this information will be useful for your research of GRN.

GLRX3; HOXA1; TNFRSF1A; TNFRSF1B; 80125

Igarashi, K; Ochiai, K; et al. Orchestration of plasma cell differentiation by Bach2 and its gene regulatory network. IMMUNOLOGICAL REVIEWS 261:116-125(2014).
Evans, RL; Pottala, JV; et al. Classifying Patients for Breast Cancer by Detection of Autoantibodies against a Panel of Conformation-Carrying Antigens. CANCER PREVENTION RESEARCH 7:545-555(2014).
  • Q&As
  • Reviews

Q&As (6)

Ask a question
Are there have any relationship between GRN protein and TDP-43 protein? 11/04/2019

There is an interaction between GRN protein and TDP-43 protein, and together they are involved in the development of neurodegenerative diseases.

Why does GRN protein play a role in neuroprotection? 07/21/2019

GRN protein is involved in neuroprotection by regulating cell survival, apoptosis, inflammatory response and other pathways. It may work by promoting neuronal survival, suppressing inflammatory responses, and more.

What is the diagnostic significance of GRN protein in neurodegenerative diseases? 06/17/2019

Abnormal expression of GRN protein is related to neurodegenerative diseases, and detecting the expression level of GRN protein or gene mutation can help diagnose these diseases and provide reference for treatment and prognosis assessment.

What is the role of GRN protein in Alzheimer's disease? 05/05/2019

The role of GRN protein in Alzheimer's disease is not fully understood, but studies have shown that it is involved in the metabolism and clearance of β-amyloid, which may have an important impact on the pathological process.

Are there transcription factors involved in the regulation of GRN protein expression? 02/26/2019

Yes, some transcription factors have been found to regulate the expression of GRN proteins, including CREB, SMAD, etc.

Which role of GRN protein in prefrontal dementia? 02/08/2019

GRN protein plays an important role in prefrontal dementia. It is involved in the survival and maintenance of nerve cells, and its deletion or mutation may lead to degenerative loss of nerve cells.

Customer Reviews (3)

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Reviews
06/16/2022

    The outstanding quality of proteins lies in their strong biological activity and their high purity during production, which is really rare.

    04/30/2022

      Application of this protein enables researchers to conduct research in more fields and broadens the horizon of scientific research.

      06/29/2019

        This protein has a short half-life, high clearance rate, and high safety and efficacy.

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