|Official Full Name||granulin|
|Background||Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis.|
|Synonyms||GRN; granulin; GEP; GP88; PEPI; PGRN; PCDGF; progranulin; Acrogranin; Granulin-1; Granulin G; Granulin-2; Granulin F; Granulin-3; Granulin-4; Granulin-5; Granulin-6; Granulin-7; Granulin A; Granulin C; Granulin D; Granulin E; granulin-epithelin; proepithelin; PC cell-derived growth factor|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
grn involved in several pathways and played different roles in them. We selected most pathways grn participated on our site, such as Integrated Breast Cancer Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with grn were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Integrated Breast Cancer Pathway||EDAR; ZMIZ1; ERAL1; CYP19A1; JAKMIP1; MYT1; GDI1; CCNB1IP1; UBE2F; GRN|
grn has several biochemical functions, for example, cytokine activity, growth factor activity, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by grn itself. We selected most functions grn had, and list some proteins which have the same functions with grn. You can find most of the proteins on our site.
|cytokine activity||TNFSF10; BMP8B; IL4; IL17A/F3; BMP7B; LTA; LEFTY1; MIF; SPP1; SPAW|
|growth factor activity||HDGF; GDF1; TIMP1; FGF9; IGF1; BMP7; COL20A1; PRL2C2; IL4; FGF10|
|poly(A) RNA binding||FTSJ3; MRPL42; GNL3; HSD17B10; NOM1; UBFD1; PTRF; MRPL54; EIF5; HNRNPA1|
|protein binding||ZNF543; AIG1; NUDT18; PPP1R2P3; CRYBA2; APOBEC2B; MRPL51; ACD; DUSP5; KLRG1|
grn has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with grn here. Most of them are supplied by our site. Hope this information will be useful for your research of grn.
GLRX3; HOXA1; TNFRSF1A; TNFRSF1B; 80125