Active Recombinant Mouse Ifng

• Cat.No.: Ifng-11M
• Product Overview: Recombinant murine IFN-γ is a 15.6 kDa protein containing 134 amino acid residues.

Specification

• Description: IFN-γ is an acid-labile interferon produced by CD4 and CD8 T lymphocytes as well as activated NK cells. IFN-γ receptors are present in most immune cells, which respond to IFN-γ signaling by increasing the surface expression of class I MHC proteins. This promotes the presentation of antigen to T-helper (CD4+) cells. IFN-γ signaling in antigen-presenting cells and antigen-recognizing B and T lymphocytes regulates the antigen-specific phases of the immune response. Additionally, IFN-γ stimulates a number of lymphoid cell functions including the anti-microbial and anti-tumor responses of macrophages, NK cells, and neutrophils. Human IFN-γ species-specific and is biologically active only in human and primate cells.
• Source: E.coli
• Species: Mouse
• Bio-activity: Determined by its ability to inhibit the proliferation of murine WEHI-279 cells. The expected ED50 is ≤ 0.2 ng/ml, corresponding to a specific activity of ≥ 5 x 10^6 units/mg.
• Molecular Mass: 15.6 kDa
• AA Sequence: MHGTVIESLE SLNNYFNSSG IDVEEKSLFL DIWRNWQKDG DMKILQSQII SFYLRLFEVL KDNQAISNNI SVIESHLITT FFSNSKAKKD AFMSIAKFEV NNPQVQRQAF NELIRVVHQL LPESSLRKRK RSRC
• Purity: Greater than 98% by SDS-PAGE gel and HPLC analyses.

Gene Information

• Gene Name: Ifng interferon gamma [ Mus musculus (house mouse) ]
• Official Symbol: Ifng
• Synonyms: Ifng; Ifg; IFN-g; interferon gamma; IFN-gamma; gamma interferon
• Gene ID: 15978
• mRNA Refseq: NM_008337
• Protein Refseq: NP_032363
• UniProt ID: P01580
• Chromosome Location: 10 D2; 10 66.75 cM
• Pathway: African trypanosomiasis; Allograft rejection; Antigen processing and presentation
• Function: cytokine activity; interferon-gamma receptor binding