Ifng

  • Official Full Name

    interferon, gamma

  • Overview

    This gene encodes a member of the type II interferon family. The protein encoded is a soluble cytokine with antiviral, immunoregulatory and anti-tumor properties and is a potent activator of macrophages. Mutations in this gene are associated with aplastic anemia.[provided by RefSeq, Nov 2009]
  • Synonyms

    IFNG; interferon, gamma; IFG; IFI; interferon gamma; IFN-gamma; immune interferon;

  • Recombinant Proteins
  • GMP Proteins
  • Cell & Tissue Lysates
  • Therapeutic Proteins
  • Transfected Stable Cell Lines
  • Protein Pre-coupled Magnetic Beads
  • Bovine
  • Canine
  • Cattle
  • Chicken
  • Cynomolgus Monkey
  • Dog
  • Equine
  • Ferret
  • Goat
  • Guinea pig
  • Hamster
  • Horse
  • Human
  • Marmota monax (Woodchuck)
  • Mouse
  • Ovine
  • Pig
  • Porcine
  • Rabbit
  • Rat
  • Rhesus
  • Rhesus Macaque
  • Sheep
  • Siniperca chuatsi (Mandarin fish)
  • Zebrafish
  • Barley Grain
  • CHO
  • CHO-K1
  • COS-7 cells
  • E. coli
  • E.coli
  • HEK293
  • HEK293F
  • Hordeum Vulgare
  • Human Cell
  • Human cells
  • Mammalian Cell
  • Mammalian cells
  • Yeast
  • C
  • hFc
  • His
  • Fc|His
  • Fc
  • His(C
  • ter)
  • Flag
  • GST
  • His (Fc)
  • Avi
  • Myc
  • His|GST
  • His|T7
  • Met
  • Myc|DDK
  • N/A
  • N
  • Strep II
  • Tag free
  • Tag Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human IFNG-510H Active Recombinant Human IFNG HEK293 N/A
Human IFNG-473H Active Recombinant Human IFNG, Met-tagged E.coli Met
Human IFNG-24H Active Recombinant Human IFNG, His-tagged Barley Grain His
Human IFNG-26H Active Recombinant Human Interferon, Gamma HEK293 N/A
Human IFNG-8549H Active Recombinant Human IFNG protein(Met1-Gln166) CHO N/A Met1-Gln166
Human IFNG-1367H Active Recombinant Human IFNG E.coli N/A
Human IFNG-8860H Active Recombinant Human IFNG, His-tagged Hordeum Vulgare N/A
Human IFNG-158HG Active GMP Recombinant Human IFNG protein E.coli N/A
Human IFNG-084H Active Recombinant Human IFNG Protein E.coli
Human IFNG-30HG Active Recombinant Human IFNG Protein (Gln24-Gln166), GMP Grade, Animal-Free E.coli Gln24-Gln166
Human IFNG-01HG Active GMP Recombinant Human IFNG Protein CHO-K1
Human IFNG-94H Recombinant Human Interferon Gamma CHO N/A
Human IFNG-116H Recombinant Human IFNG protein HEK293 143
Human IFNG-257H Recombinant Human IFNG, StrepII-tagged Human Cell Strep II 24-161, 138 a.a.
Human IFNG-28243TH Recombinant Human IFNG, His-tagged E.coli His
Human IFNG-480H Recombinant Human IFNG protein, His-tagged HEK293F His Gln24~Gln166
Human IFNG-145H Recombinant Human Interferon, Gamma, His-tagged E.coli His
Human IFNG-605H Recombinant Human IFNG protein E.coli N/A 144
Human IFNG-28244TH Recombinant Human IFNG, His-tagged E.coli His
Human IFNg-31H Recombinant Human IFN gamma Yeast N/A
Human IFNG-15833H Recombinant Human IFNG, His-tagged E.coli His 24-161aa
Human IFNG-29196TH Recombinant Human IFNG E.coli N/A 143 amino acids
Human IFNG-685H Recombinant Human Interferon, Gamma, HQ-tagged Hordeum Vulgare N/A
Human IFNG-001HCL Recombinant Human IFNG cell lysate CHO N/A
Human IFNG-P011H Recombinant Human IFNG therapeutic protein E.coli N/A 146aa
Human IFNG-88H Human Interferon Gamma (rDNA derived) Reference standard N/A
Human IFNG-4347HG GMP Recombinant Human IFNG protein E.coli N/A 144
Human IFNG-119H Recombinant Active Human IFNG Protein, His-tagged(C-ter) E.coli His(C-ter)
Human IFNG-67H Human Interferon Gamma (Leukocyte derived) Reference standard N/A
Human IFNG-1184H Recombinant Human IFNG Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human IFNG-157HG Active GMP Recombinant Human IFNG Protein HEK293 N/A
Human IFNG-380I Active Recombinant Human IFNG Protein (144 aa) E.coli 144
Human IFNG-50H Recombinant Human IFNG Protein E.coli
Human IFNG-579HB Recombinant Human IFNG protein, His-Avi-tagged, Biotinylated HEK293 His-Avi Gln24-Gly161
Human IFNG-579H Recombinant Human IFNG protein, His-Avi-tagged HEK293 His-Avi Gln24-Gly161
Human IFNG-156H Active Recombinant Human IFNG Protein (Gln24-Gln166), C-His tagged, Animal-free, Carrier-free E.coli C-His Gln24-Gln166
Human IFNG-5432H Recombinant Human IFNG protein, His-tagged Yeast His 24-161aa
Human IFNG-74H Recombinant Human IFNG Protein Human Cell
Human IFNG-587HG Active GMP Recombinant Human IFNG protein CHO
Human IFNG-72HFL Recombinant Full Length Human IFNG Protein, C-Flag-tagged Mammalian cells Flag
Human IFNG-99H Active Recombinant Human IFNG Protein E.coli Gln24-Gln166
Human IFNG-2506H Recombinant Human IFNG Protein (Gln24-Gln166) Mammalian cells Tag Free Gln24-Gln166
Human IFNG-21H Active Recombinant Human IFNG Protein, Animal Free Human cells
Human IFNG-78H Recombinant Human IFNG Protein E.coli Tag free
Human IFNG-264I Active Recombinant Human IFNG Protein CHO
Human IFNG-22H Active Recombinant Human IFNG Protein E.coli
Human IFNG-497H Recombinant Human IFNG Protein 166
Human IFNG-105I Active Recombinant Human IFNG Protein (144 aa) E.coli 144
Human IFNG-6015H Active Recombinant Human IFNG protein E.coli N/A Gln24-Gln166
Human IFNG-1150H Recombinant Human IFNG Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human IFNG-1150H-B Recombinant Human IFNG Protein Pre-coupled Magnetic Beads HEK293
Human IFNG-115H Active Recombinant Human IFNG Protein E.coli
Human IFNG-241H Active Recombinant Human IFNG Protein E.coli Tag Free
Human IFNG-2508H Recombinant Human IFNG Protein (Gln24-Gly161), N-His tagged E.coli N-His Gln24-Gly161
Mouse IFNG-893M Active Recombinant Mouse IFNG Protein, His-tagged HEK293 His
Mouse Ifng-11M Active Recombinant Mouse Ifng E.coli N/A
Mouse Ifng-601M Active Recombinant Mouse Ifng E.coli Met His23-Cys155
Mouse Ifng-01M Active Recombinant Mouse Ifng Protein, His-Tagged E.coli His
Mouse Ifng-532M Recombinant Mouse Ifng protein, His-tagged E.coli His His23~Cys155
Mouse Ifng-119M Recombinant Mouse Ifng protein(Met1-Cys155), hFc-tagged HEK293 C-hFc Met1-Cys155
Mouse Ifng-488M Recombinant Mouse Ifng protein, His-tagged HEK293F His His23~Cys155
Mouse Ifng-114M Recombinant Mouse Ifng protein E.coli N/A 133
Mouse Ifng-10M Recombinant Mouse Ifng protein(His23-Cys155) E. coli N/A His23-Cys155
Mouse Ifng-510M Active Recombinant Mouse Ifng protein HEK293 N/A Met1-Cys155
Mouse IFNG-1797MCL Recombinant Mouse IFNG cell lysate Human Cell N/A
Mouse Ifng-365MG Active GMP Recombinant Mouse Ifng protein HEK293 DNA sequence encoding Mouse Ifng (NP_032363.1) was expressed with His tag at the C-terminal.
Mouse Ifng-077M Active Recombinant Mouse Ifng Protein E.coli
Mouse Ifng-5686M Recombinant Mouse Ifng Protein (His23-Cys155), C-His tagged Mammalian cells C-His His23-Cys155
Mouse IFNG-116M Active Recombinant Mouse IFNG Protein E.coli
Mouse Ifng-3076M Recombinant Mouse Ifng protein, His-tagged E.coli His 27-155aa
Mouse Ifng-6731M Recombinant Mouse Ifng Protein (His23-Cys155) E.coli Tag Free His23-Cys155
Mouse Ifng-42M Active Recombinant Mouse Ifng Protein (His23-Cys155), C-His tagged, Animal-free, Carrier-free E.coli C-His His23-Cys155
Mouse Ifng-6732M Recombinant Mouse Ifng Protein (His23-Cys155) Mammalian cells Tag Free His23-Cys155
Mouse Ifng-379I Active Recombinant Mouse Ifng Protein (134 aa) E.coli 134
Mouse Ifng-031I Active Recombinant Mouse Ifng Protein (134 aa) E.coli 134
Mouse Ifng-078M Active Recombinant Mouse Ifng Protein E.coli
Rat Ifng-115R Recombinant Rat Ifng protein E.coli N/A 134
Rat Ifng-549R Recombinant Rat Ifng protein, His-tagged E.coli His Gln23~Cys156
Rat Ifng-806R Recombinant Rat Ifng protein, His & GST-tagged E.coli His/GST Gln23~Cys156 (Accession # P01581)
Rat Ifng-470R Recombinant Rat Ifng protein, His-tagged HEK293F His Gln23~Cys156
Rat Ifng-7469R Active Recombinant Rat Ifng protein, hFc-tagged HEK293 hFc Met1-Cys156
Rat Ifng-11R Recombinant Rat Interferon-γ E.coli N/A
Rat IFNG-2997R Recombinant Rat IFNG Protein Mammalian Cell His
Rat IFNG-1536RCL Recombinant Rat IFNG cell lysate Human Cell N/A
Rat IFNG-117R Recombinant Rat IFNG Protein E.coli
Rat IFNG-2653R Recombinant Rat IFNG Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Ifng-009I Active Recombinant Rat Ifng Protein (135 aa) E.coli 135
Rat IFNG-2653R-B Recombinant Rat IFNG Protein Pre-coupled Magnetic Beads HEK293
Rat Ifng-192R Active Recombinant Rat Ifng Protein E.coli Tag Free
Rat Ifng-263I Active Recombinant Rat Ifng Protein CHO
Rat Ifng-378I Active Recombinant Rat Ifng Protein (134 aa) E.coli 134
Rat Ifng-118R Recombinant Rat IFNG Protein, Fc-His-tagged(C-ter) HEK293 Fc-His(C-ter) Gln23-Cys156
Rat Ifng-3078R Recombinant Rat Ifng protein, GST-tagged E.coli GST 23-156aa
Rabbit IFNG-807R Recombinant Rabbit IFNG protein, His-tagged E.coli His Gln24~Tyr167
Rabbit IFNG-497R Recombinant Rabbit IFNG protein, His-tagged HEK293F His Gln24~Tyr167
Rabbit IFNg-28R Recombinant Rabbit IFN gamma Yeast N/A
Rabbit IFNG-116R Recombinant Rabbit IFNG Yeast N/A
Dog IFNG-801D Recombinant Dog IFNG protein, His & T7-tagged E.coli His/T7 Gln24~Lys166 (Accession # P42161)
Bovine IFNG-61B Active Recombinant Bovine Interferon, Gamma Yeast N/A
Bovine IFNG-857B Active Recombinant Bovine IFNG E.coli Met Gln24-Thr166 & Gln24-Arg162
Bovine IFNG-130B Recombinant Bovine Interferon, Gamma COS-7 cells N/A
Bovine IFNG-8157B Recombinant Bovine IFNG protein, His-tagged E.coli N-His 24-166aa
Canine IFNG-7822C Recombinant Canine IFNG protein E.coli N/A 143
Cattle IFNG-800C Recombinant Cattle IFNG protein, His-tagged E.coli His Gln24~Thr166 (Accession # P07353)
Cynomolgus Monkey IFNG-1165C Active Recombinant Cynomolgus IFNG Protein E.coli N/A
Cynomolgus Monkey IFNG-612C Recombinant Cynomolgus IFNG Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey IFNG-359C-B Recombinant Cynomolgus Monkey IFNG Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey IFNG-359C Recombinant Cynomolgus Monkey IFNG Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Equine IFNg-19E Recombinant Equine IFN gamma Yeast N/A
Equine IFNG-64E Recombinant Equine Interferon, Gamma Yeast N/A
Ferret IFNG-325F Recombinant Ferret IFNG, His tagged Human Cell Fc/His
Ferret IFNG-1007FCL Recombinant Ferret IFNG cell lysate Human Cell N/A
Ferret IFNG-2404F Recombinant Ferret IFNG protein(Met1-Lys166), His-tagged HEK293 C-His Met1-Lys166
Ferret IFNG-4340F Recombinant Ferret IFNG Protein Yeast N/A 164aa
Goat IFNG-4318G Recombinant Goat IFNG protein, His&Myc-tagged E.coli His&Myc 24-166aa
Guinea pig Ifng-803G Recombinant Guinea pig Ifng protein, His-tagged E.coli His Gln24~Lys166
Hamster Ifng-019H Recombinant Hamster Ifng Protein, Met1-Ile174, C-His tagged HEK293 C-His Met1-Ile174
Horse IFNG-440E Recombinant Horse IFNG protein E.coli N/A 143
Horse IFNG-981H Recombinant Horse IFNG Protein, His-tagged E.coli N-His Ala25-Gln166
Marmota monax (Woodchuck) IFNG-1254M Recombinant Marmota monax IFNG Protein, His-tagged Yeast His
Marmota monax (Woodchuck) IFNG-3077M Recombinant Marmota monax (Woodchuck) IFNG protein, His-tagged E.coli His 24-166aa
Ovine IFNg-51O Recombinant Ovine IFN gamma Yeast N/A
Porcine IFNG-01P Active GMP Recombinant Porcine IFNG Protein, His-Tagged E.coli His
Rhesus IFNG-1165R Active Recombinant Rhesus Protein E.coli N/A Gln24-Gln165
Rhesus IFNG-1164R Recombinant Rhesus IFNG protein(Met1-Gln165), His-tagged HEK293 C-His Met1-Gln165
Rhesus IFNG-74R Recombinant Rhesus IFNG protein E.coli N/A 142
Rhesus Macaque IFNG-2207R Recombinant Rhesus monkey IFNG Protein, His-tagged Mammalian Cell His
Rhesus Macaque IFNG-2028R Recombinant Rhesus Macaque IFNG Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque IFNG-2028R-B Recombinant Rhesus Macaque IFNG Protein Pre-coupled Magnetic Beads HEK293
Sheep IFNG-804S Recombinant Sheep IFNG protein, His-tagged E.coli His Gln24~Met166 (Accession # P17773)
Sheep IFNG-5433S Recombinant Sheep IFNG protein, His-tagged Yeast His 24-166aa
Siniperca chuatsi (Mandarin fish) IFNG-5677S Recombinant Mandarin fish IFNG Protein (Met1-Ala208), His tagged E.coli His Met1-Ala208
Zebrafish IFNG-13Z Recombinant Zebrafish IFN gamma 1 Protein, 146 Yeast
Pig IFNG-805P Recombinant Pig IFNG protein, His-tagged E.coli His Ser21~Lys166
Pig IFNG-21P Recombinant Porcine Interferon-gamma E.coli N/A
Pig IFNg-3366P Recombinant Pig IFNg protein, His-tagged HEK293 His Ser21~Lys166
Pig IFNG-198P Active Recombinant Pig IFNG Protein (Gln23-Lys166), C-His tagged, Animal-free, Carrier-free E.coli C-His Gln23-Lys166
Chicken IFNG-63C Recombinant Chicken Interferon, Gamma Yeast N/A
Chicken IFNG-6706C Recombinant Chicken IFNG Mammalian Cell His
Chicken IFNG-802C Recombinant Chicken IFNG protein, His-tagged E.coli His His20~Cys164
Chicken IFNG-3075C Recombinant Chicken IFNG protein, GST-tagged E.coli GST 20-164aa
  • Background
  • Quality Guarantee
  • Case Study
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource
  • Ifng Related Signal Pathway
IFNG-9.jpg

Fig1. IFN-γ-producing immune cells and key functions. (Jonathan Thuner, 2023)

What is IFNG protein?

IFNG (interferon gamma) gene is a protein coding gene which situated on the long arm of chromosome 12 at locus 12q15. This gene encodes a soluble cytokine that is a member of the type II interferon class. The encoded protein is secreted by cells of both the innate and adaptive immune systems. The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial infections. The IFNG protein is consisted of 166 amino acids and its molecular mass is approximately 19.3 kDa.

What is the function of IFNG protein?

IFNG is an immunomodulatory protein that is primarily released by activated lymphocytes and has a variety of functions. IFN-γ can promote the antiviral ability of host cells, enhance the activity of macrophages, promote the activation of T cells and B cells, and regulate the inflammatory response, which plays an important role in immune response and anti-microbial infection. In addition, IFN-γ can inhibit cell proliferation and regulate immune tolerance and other physiological processes.

IFNG Related Signaling Pathway

IFNG is primarily signaling through its receptor IFNGR, and when IFNG binds to the receptor, it induces dimer subunits of the receptor and activates intracellular Janus kinases (JAKs), which leads to phosphorylation of signal transduction and transcriptional activators (STATs), especially STAT1. Phosphorylated STAT1 dimerizes and is transferred into the nucleus to regulate expression of specific genes, including interferon-stimulated response element (ISRE). In addition, IFN-γ also activates other signaling pathways, such as the MAPK and PI3K/Akt pathways, which are closely related to the regulation of cell proliferation, survival, and inflammatory response.

IFNG Related Diseases

Diseases associated with this protein include immune deficiency diseases, autoimmune diseases, chronic inflammatory diseases, and certain infectious diseases. Its abnormal function or overactivation can lead to dysregulation of the immune response, triggering a variety of inflammation and diseases, including rheumatoid arthritis, inflammatory bowel disease, systemic lupus erythematosus and others. In the tumor microenvironment, IFNG has a complex bidirectional effect, both promoting anti-tumor immune response and possibly supporting immune evasion and tumor growth. Changes in their levels can affect the development of many cancers.

IFNG-10.jpg

Fig2. Immune surveillance and escape from IFN-γ-dependent anticancer activity. (Chiou-Feng Lin, 2017)

Bioapplications of IFNG

Using its powerful broad-spectrum activity against viruses, bacteria and parasites, IFNG is used to treat infections including tuberculosis, chronic granulomatosis and other refractory infections. In vaccine development, IFNG can be used as a molecular adjuvant to enhance the immune response triggered by the vaccine and improve the efficiency of antigen presentation, thereby enhancing the efficacy of the vaccine.

High Purity

High Bioactivity

IFNG-2.jpg

Fig2. Activity Data. (IFNG-116H)

Case study 1: Katelyn J McCann, 2022

Interferon γ (IFNγ) is an essential and pleiotropic activator of human monocytes, but little is known about the changes in cellular metabolism required for IFNγ-induced activation. We sought to elucidate the mechanisms by which IFNγ reprograms monocyte metabolism to support its immunologic activities. IFNγ increased oxygen consumption rates (OCR) in monocytes, indicative of reactive oxygen species generation by both mitochondria and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase. Transcriptional profiling revealed that this oxidative phenotype was driven by IFNγ-induced reprogramming of NAD+ metabolism, which is dependent on nicotinamide phosphoribosyltransferase (NAMPT)-mediated NAD+ salvage to generate NADH and NADPH for oxidation by mitochondrial complex I and NADPH oxidase, respectively. Interestingly, inhibition of NAMPT in healthy monocytes completely abrogated the IFNγ-induced oxygen consumption, comparable to levels observed in CGD monocytes. These data identify an IFNγ-induced, NAMPT-dependent, NAD+ salvage pathway that is critical for IFNγ activation of human monocytes.

IFNG-3.jpg

Fig1. Primary human monocytes were stimulated with media alone, LPS, IFNγ, or LPS plus IFNγ for 24 hours prior to the start of the assay, then ECAR was measured according to the Seahorse Glycolysis Stress Test.

IFNG-4.jpg
Fig2. IFNγ-induced increases in OCR are unique to type II interferon and not dependent on total mitochondrial mass, glucose uptake, or substrate-specific catabolism.

Case study 2: Julian J Freen-van Heeren, 2020

Long-lasting CD8+ T cell responses are critical in combatting infections and tumors. The pro-inflammatory cytokine IFN-γ is a key effector molecule herein. They researchers recently showed that in murine T cells the production of IFN-γ is tightly regulated through adenylate uridylate-rich elements (AREs) that are located in the 3' untranslated region (UTR) of the Ifng mRNA molecule. Loss of AREs resulted in prolonged cytokine production in activated T cells and boosted anti-tumoral T cell responses. Here, they investigated whether these findings can be translated to primary human T cells.

Utilizing CRISPR-Cas9 technology, they deleted the ARE region from the IFNG 3' UTR in peripheral blood-derived human T cells. Loss of AREs stabilized the IFNG mRNA in T cells and supported a higher proportion of IFN-γ protein-producing T cells. Importantly, combining MART-1 T cell receptor engineering with ARE-Del gene editing showed that this was also true for antigen-specific activation of T cells. MART-1-specific ARE-Del T cells showed higher percentages of IFN-γ producing T cells in response to MART-1 expressing tumor cells.

IFNG-5.jpg

Fig3. Representative concatenated flow cytometry dot plots of IFN-γ production of control and ARE-Del T cells after removal from stimulus for indicated time points.

IFNG-6.jpg
Fig4. Representative concatenated flow cytometry dot plots of IFN-γ production of control and ARE-Del T cells after 6, 24, and 48 h of co-culture with MART-1+ and MART-1− tumor cells.
IFNG-7.jpg

Fig1. Diagram of pathways by which IFNγ regulates cellular NAD+ metabolism. (Katelyn J McCann, 2022)

IFNG-8.jpg

Fig2. IFN-γ and IL-17 signaling pathways working together, separately. (Hui Dai, 2020)

Ifng involved in several pathways and played different roles in them. We selected most pathways Ifng participated on our site, such as Proteasome, Cytokine-cytokine receptor interaction, HIF- signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Ifng were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ProteasomePSMA5;PSMD3;PSMD4B;PSMA3;PSMB8;PSMD12;PSMD8;PSMD13;PSMB11
Cytokine-cytokine receptor interactionIl23a; Il12b;IFNB;EDA;BMPR1B;PRL;CXCR6;INHBC;M17;MET
HIF- signaling pathwayCUL2;ALDOA;ENO2;MAP2K1;RBX1;NOX1;TIMP1;PLCG2;SLC2A1
Regulation of autophagyULK2;IFNA14;ATG14;IFNA3;ULK3;ATG7;IFNA16;PRKAA1;IFNA4
TGF-beta signaling pathwayBMP7A;BMPR1AA;BMP7B;SMAD7;SMAD4;BMP7;RHOA;INHBB;RPS6KB1
Osteoclast differentiationTYROBP;LILRA1;PIK3CG;OSCAR;MAP2K7;MAPK8;NOX1;TRAF6;CSF1R
Antigen processing and presentationHSPA6;HLA-F;HLA-DQA1;LGMN;RFXAP;HLA-A;IFI30;RFXANK;KIR2DS4
Jak-STAT signaling pathwayGM-CSF;LIF;IFNPHI3;IRX1;CSH2;IFNE;PTPN2B;IL5RA;IL3RA
Natural killer cell mediated cytotoxicityIFNA1;SYK;PIK3CB;FYN;PIK3CG;KIR2DL3;FCGR3;Casp3;SHC1
T cell receptor signaling pathwayMUC1;CD8A;DLG1;PPP3R1;PDPK1;PIK3CD;NFKBIE;MAP2K7;CD247
Type I diabetes mellitusCPE;HLA-DRB5;HLA-DMA;HLA-DRB3;HLA-F;Il2;HLA-A;HLA-B;HLA-C
Salmonella infectionARPC4L;KLC2;PFN4;DYNC1LI2;RILP;FLNB;FLNA;RAC1B;PFN1
LeishmaniasisNOS2;HLA-DRB5;MAPK12;ITGB1;STAT1;MARCKSL1;FCGR3A;Itgam&Itgb2;TGFB3
Chagas disease (American trypanosomiasis)ACE;PPP2R1B;PIK3R1;CASP8;CD3E; CD3D;MAPK13;IFNG;GNAS;PIK3R3
African trypanosomiasisF2RL1;PLCB3;IL18;HPR;HBB-B1;APOL1;FASLG;IL1B2;IL10
MalariaGYPC;GYPB;SDC2;HBB;KLRB1;KLRK1;DARC;COMP;CD81
ToxoplasmosisIFNGR2;CYCS;BCL2;BIRC8;HLA-DPA1;Toxoplasma Gondii Microneme Protein MIC3;TYK2;TLR2;H2-AB1
AmoebiasisCOL2A1;SERPINB10;ACTN3;LAMB4;VCL;GNA14;LAMC3;GM-CSF;GNAL
TuberculosisCD209A;FCGR1A;CAMK2A;VDR;TNF;ITGB2;MAPK8;Casp3;MRC1
MeaslesTNFRSF10D;CCND1;Fasl;Ifna11;TLR9;IL12B;IFIH1;IL1B;AKT2
Influenza APRSS2;PIK3CG;IFNA4;MAPK12;HSPA1A;KPNA2;NXF1;IFNA7;PIK3CA
Herpes simplex infectionMAPK8B;HLA-B;STAT2;IFNG;ABCB3L1;PPP1CAA;HLA-DOB;NXF2;UBE2R2
Epstein-Barr virus infectionMAPK10;TRAF5;CDK1;POLR2I;YWHAE;RBPJL;IFNG;HLA-DRB5;HLA-DPA1
Inflammatory bowel disease (IBD)HLA-DRB5;IFNGR1;HLA-DQA1;NFKB1;STAT4;HLA-DOA;IL6;TBX21;TNF
Systemic lupus erythematosusHIST1H4I;HIST2H3C2;HIST1H3E;HIST1H2BO;HLA-DQB1;HIST1H2AL;H2AFX;HIST1H2BL;HIST1H2AC
Rheumatoid arthritisANGPT1;MMP1;IL11;ATP6V0E;IL-8;Ccl12;IL1B;HLA-DQA2;TNFSF13B
Allograft rejectionHLA-B;HLA-DRB1;HLA-DQA1;HLA-DPB1;CD40;HLA-DMA;HLA-A;HLA-F;CD86
Graft-versus-host diseaseHLA-E;H2-AA;H2-Q10;HLA-DRB1;IFNG;HLA-DRB4;CD80;KLRC1;HLA-DQB1

Ifng has several biochemical functions, for example, cytokine activity, interferon-gamma receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Ifng itself. We selected most functions Ifng had, and list some proteins which have the same functions with Ifng. You can find most of the proteins on our site.

Function Related Protein
cytokine activityIFNA5;SECTM1;IL18;IL17F;INHBB;LIF;RNF207B;IFNA7;IFNG1-2
interferon-gamma receptor bindingDNAJA3;IFNG;IFNG1-2;IFNG1-1

Ifng has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Ifng here. Most of them are supplied by our site. Hope this information will be useful for your research of Ifng.

IFNGR1; b8_vaccw

Research Area

Related articles

Voigt, RM; Keshavarzian, A; et al. HIV-associated mucosal gene expression: region-specific alterations. AIDS 29:537-546(2015).
Lv, W; Duan, QL; et al. Expression of B-cell-associated genes in peripheral blood mononuclear cells of patients with symptomatic pulmonary embolism. MOLECULAR MEDICINE REPORTS 11:2299-2305(2015).
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Q&As (6)

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What is the role of IFNG in tumor immunotherapy? 09/23/2022

IFNG plays an important role in tumor immunotherapy, which can activate the immune response of tumor cells, promote apoptosis of tumor cells and inhibit the proliferation of tumor cells.

What is the current progress in drug development for IFNG? 12/19/2021

The development of drugs for IFNG is currently in clinical trials, including monoclonal antibodies against IFNG receptors and inhibitors against IFNG signaling pathways.

How is IFNG related to muscle wasting? 12/02/2021

Studies have shown that IFNG can inhibit the occurrence of muscle atrophy, but the specific mechanism is not clear.

How can IFNG be used as a biomarker in clinical practice? 03/01/2021

In clinical practice, the expression level of IFNG can be measured to predict the progression and prognosis of the disease, and to guide the choice of treatment regimen.

Are there other coding variants in the IFNG gene? 07/12/2020

Yes, there are other coding variants in the IFNG gene that may have different functions and expression patterns.

Is the expression of IFNG affected by environmental factors? 05/26/2020

Such as nutritional status, inflammation levels, etc. Yes, the expression of IFNG is affected by environmental factors, such as nutritional status, inflammation level, etc.

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12/17/2022

    It is analyzed by X-ray crystallography or other crystallization techniques and has good crystallization properties.

    06/10/2022

      Easy to attach to the surface of cells or materials.

      04/02/2022

        IFNG products have a complete range of specifications for experimental designs of different sizes and needs.

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