Recombinant Human POMT1, GST-tagged

• Cat.No.: POMT1-1856H
• Product Overview: Recombinant Human POMT1 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Source: E.coli
• Species: Human
• Tag: GST
• Protein length: 285-595aa
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: POMT1?protein-O-mannosyltransferase 1 [?Homo sapiens?(human) ]
• Official Symbol: POMT1
• Synonyms: POMT1; RT; LGMD2K; MDDGA1; MDDGB1; MDDGC1; protein-O-mannosyltransferase 1; protein O-mannosyl-transferase 1; dolichyl-phosphate-mannose-protein mannosyltransferase; dolichyl-phosphate-mannose--protein mannosyltransferase 1; NP_001070833.1; EC 2.4.1.109; NP_001070834.1; NP_001129585.1; NP_009102.3
• Gene ID: 10585
• mRNA Refseq: NM_001077365
• Protein Refseq: NP_001070833
• MIM: 607423
• UniProt ID: Q9Y6A1
• Chromosome Location: 9q34.1
• Pathway: Other types of O-glycan biosynthesis
• Function: dolichyl-phosphate-mannose-protein mannosyltransferase activity; mannosyltransferase activity; metal ion binding

Reviews

02/25/2022

Timely results. Accelerates our research timelines.

11/18/2019

Exceptional accuracy. Key to successful research.

10/08/2017

Reliable data source. A vital research asset.

Q&As

How do genetic variations in POMT1 affect muscle function and development?

Genetic defects in POMT1 can lead to impaired muscle development and function, contributing to muscular dystrophies.

What potential therapeutic applications arise from targeting POMT1 in muscular dystrophies?

Targeting POMT1 in therapy could provide new treatments for various forms of muscular dystrophy.

What is the impact of altered POMT1 activity on neuromuscular diseases?

Altered POMT1 activity impacts the stability and function of muscle proteins, exacerbating neuromuscular diseases.

What role does POMT1 play in cell membrane integrity?

POMT1 plays a role in maintaining cell membrane integrity, crucial for muscle and nerve cells.

How does POMT1 interact with other enzymes in the glycosylation pathway?

POMT1 works with other glycosylation enzymes, playing a critical role in protein modification processes.

What is the primary role of POMT1 in protein glycosylation?

POMT1 is involved in the O-mannosylation of proteins, an important type of glycosylation for protein function.

How does POMT1 contribute to muscular dystrophy disorders?

Mutations in POMT1 are linked to certain types of muscular dystrophies, affecting muscle structure and function.