Active Recombinant Human IMPDH2

• Cat.No.: IMPDH2-83H
• Product Overview: Recombinant Human IMPDH2 has been cloned by RT-PCR amplification of mRNA extracted from human hepatoma cells (sequence confirmed) and expressed in E.coli. Purified IMPDH 2 is an active enzyme characterized for its affinity for inosine 5'-monophosphate and NAD substrates, and its sensitivity to enzyme inhibitors such as mycophenolic acid and ribavirine-monophosphate.

Specification

• Description: This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation.
• Source: E. coli
• Species: Human
• Bio-activity: ≥ 0.050 unit/mg protein.
• Unit Definition: One unit of IMPDH Type II catalyzes the oxydation of 1 µmole of IMP to XMP per minute at pH 8.8 at 37 °C

Gene Information

• Gene Name: IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2 [ Homo sapiens (human) ]
• Official Symbol: IMPDH2
• Synonyms: IMPDH2; IMP (inosine 5"-monophosphate) dehydrogenase 2; IMPD2; IMPDH-II; EC 1.1.1.205; Inosine-5"-monophosphate dehydrogenase 2; IMP dehydrogenase 2
• Gene ID: 3615
• mRNA Refseq: NM_000884
• Protein Refseq: NP_000875
• MIM: 146691
• UniProt ID: P12268
• Chromosome Location: 3p21.2
• Pathway: Drug metabolism - other enzymes; Metabolic pathways; Purine metabolism; Metabolism of nucleotides
• Function: IMP dehydrogenase activity; metal ion binding; oxidoreductase activity; protein binding