IMPDH1

  • Official Full Name

    IMP (inosine 5-monophosphate) dehydrogenase 1

  • Overview

    The protein encoded by this gene acts as a homotetramer to regulate cell growth. The encoded protein is an enzyme that catalyzes the synthesis of xanthine monophosphate (XMP) from inosine-5-monophosphate (IMP). This is the rate-limiting step in the de novo synthesis of guanine nucleotides. Defects in this gene are a cause of retinitis pigmentosa type 10 (RP10). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]

  • Synonyms

    IMPDH1;IMP (inosine 5-monophosphate) dehydrogenase 1;IMPD;RP10;IMPD1;LCA11;sWSS2608;inosine-5-monophosphate dehydrogenase 1;IMPD 1;IMPDH 1;IMPDH-I;IMP dehydrogenase 1;IMP (inosine monophosphate) dehydrogenase 1

Recombinant Proteins

  • Human
  • Mouse
  • Sf21 Cells
  • E.coli
  • Mammalian Cells
  • HEK293
  • In Vitro Cell Free System
  • His
  • Non
  • DDK
  • Myc
  • Avi
  • Fc
  • GST
Cat.# Product name Source (Host) Species Tag Protein Length Price
IMPDH1-01H Active Recombinant Human IMPDH1 Protein, His-Tagged Sf21 Cells Human His
IMPDH1-28268TH Recombinant Human IMPDH1, His-tagged E.coli Human His 514 amino acids
IMPDH1-8198M Recombinant Mouse IMPDH1 Protein Mammalian Cells Mouse His
IMPDH1-5211HCL Recombinant Human IMPDH1 293 Cell Lysate HEK293 Human Non
IMPDH1-280H Recombinant Human IMPDH1 protein, His-tagged E.coli Human His
Impdh1-3531M Recombinant Mouse Impdh1 Protein, Myc/DDK-tagged HEK293 Mouse DDK&Myc
IMPDH1-4534M Recombinant Mouse IMPDH1 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
IMPDH1-4534M-B Recombinant Mouse IMPDH1 Protein Pre-coupled Magnetic Beads HEK293 Mouse
IMPDH1-4548H Recombinant Human IMPDH1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293 Human DDK&Myc
IMPDH1-5865HF Recombinant Full Length Human IMPDH1 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 563 amino acids

    Involved Pathway

    IMPDH1 involved in several pathways and played different roles in them. We selected most pathways IMPDH1 participated on our site, such as Purine metabolism,Drug metabolism - other enzymes,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with IMPDH1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Metabolic pathways GM5506,SGMS1,OCRL,POLA1,INPP4B,TKTL1,SARDH,G6PD,NT5C3L,GGPS1
    Drug metabolism - other enzymes UGT1A7,UGT5G1,NAT1,GUSB,UPP2,UPP1,TPMT.1,UGT1A1,NAT,UGT1AB
    Purine metabolism PDE4D,AK1,POLR2L,AK8,NPR1,PPAT,PNP5B,ITPA,PDE3B,PDE6A

    Protein Function

    IMPDH1 has several biochemical functions, for example, DNA binding,IMP dehydrogenase activity,RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IMPDH1 itself. We selected most functions IMPDH1 had, and list some proteins which have the same functions with IMPDH1. You can find most of the proteins on our site.

    Function Related Protein
    RNA binding SMARCE1,NOP56,HENMT1,EIF4EB,FAM103A1,RBMY1B,OASL1,PPIE,CTU1,U2SURP
    DNA binding TCEANC,EN1,LASS5,RX3,TOMM20A,RABGEF1L,HIST3H2A,MIER1A,ERCC6L2,SSRP1A
    IMP dehydrogenase activity IMPDH1A,IMPDH1B,IMPDH2
    nucleic acid binding REXO4,SETD1B,ZNFL2A,ZKSCAN14,ATF7A,QK,ZIC6,MSI2A,ENPP1,ZFP354C
    metal ion binding ZMYND17,ITGA9,TUT1,PAPOLG,ZNF773,OLA1,COLEC12,ZNF670,RHEB,BTK

    Interacting Protein

    IMPDH1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IMPDH1 here. Most of them are supplied by our site. Hope this information will be useful for your research of IMPDH1.

    GMNN;q7cfv5_yerpe;HTRA1;MYO1C;SEC16A;XRCC3;Junb;Lgals3bp;EMC2;Rpl35;MMGT1

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