Recombinant Human IMPDH2 Protein, GST-tagged

• Cat.No.: IMPDH2-5138H
• Product Overview: Human IMPDH2 full-length ORF ( AAH12840, 1 a.a. - 514 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5-monophosphate into xanthine-5-monophosphate, which is then converted into guanosine-5-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation. [provided by RefSeq
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 82.17 kDa
• AA Sequence: MADYLISGGTSYVPDDGLTAQQLFN CGDGLTYNDFLILPGYIDFTADQVD LTSALTKKITLKTPLVSSPMDTVTE AGMAIAMALTGGIGFIHHNCTPEFQ ANEVRKVKKYEQGFITDPVVLSPKD RVRDVFEAKARHGFCGIPITDTGRM GSRLVGIISSRDIDFLKEEEHDCFL EEIMTKREDLVVAPAGITLKEANEI LQRSKKGKLPIVNEDDELVAIIART DLKKNRDYPLASKDAKKQLLCGAAI GTHEDDKYRLDLLAQAGVDVVVLDS SQGNSIFQINMIKYIKDKYPNLQVI GGNVVTAAQAKNLIDAGVDALRVGM GSGSICITQEVLACGRPQATAVYKV SEYARRFGVPVIADGGIQNVGHIAK ALALGASTVMMGSLLAATTEAPGEY FFSDGIRLKKYRGMGSLDAMDKHLS SQNRYFSEADKIKVAQGVSGAVQDK GSIHKFVPYLIAGIQHSCQDIGAKS LTQVRAMMYSGELKFEKRTSSAQVE GGVHSLHSYEKRLF
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: IMPDH2 IMP (inosine 5-monophosphate) dehydrogenase 2 [ Homo sapiens ]
• Official Symbol: IMPDH2
• Synonyms: IMPDH2; IMP (inosine 5-monophosphate) dehydrogenase 2; inosine-5-monophosphate dehydrogenase 2; IMPD 2; IMPDH 2; IMP oxireductase 2; inosine 5 phosphate dehydrogenase 2; IMP (inosine monophosphate) dehydrogenase 2; inosine monophosphate dehydrogenase type II; IMPD2; IMPDH-II
• Gene ID: 3615
• mRNA Refseq: NM_000884
• Protein Refseq: NP_000875
• UniProt ID: P12268