"DHH" Related Products

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Recombinant Human Desert Hedgehog Homolog (Drosophila)

Cat. No.: DHH-345H
Product Overview: Recombinant DHH protein was expressed in E.coli and purified by using conventional chromatography techniques(197 aa, 22 kDa).
Description: DHH belongs to the hedgehog family. The C-terminal domain displays an autoproteolysis activity and a cholesterol transferase activity. The N- terminal domain is the active species in both local and long-range signaling, whereas the C-terminal domain has no signaling activity. This protein is produced by Sertoli cells and may be involved in both male gonadal differentiation and perineurial development. Defects in this protein have been associated with partial gonadal dysgenesis (PGD) accompanied by minifascicular polyneuropathy.
Source: E.coli.
Formulation: Liquid. In 20 mM MES buffer (pH 5.5) containing 0.5 mM DTT, 20% glycerol.
Molecular Weight: 22 kDa (197aa).
Purity: > 95% by SDS – PAGE.
Concentration: 1 mg/ml (determined by Bradford assay).
Sequence: MGSSHHHHHH SSGLVPRGSH MCGPGRGPVG RRRYARKQLV PLLYKQFVPG VPERTLGASG PAEGRVARGS ERFRDLVPNY NPDIIFKDEE NSGADRLMTE RCKERVNALA IAVMNMWPGV RLRVTEGWDE DGHHAQDSLH YEGRALDITT SDRDRNKYGL LARLAVEAGF DWVYYESRNH VHVSVKADNS LAVRAGG
Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Gene Name: DHH
Synonyms: DHH; desert hedgehog homolog (Drosophila); HHG-3; MGC35145; desert hedgehog; desert hedgehog (Drosophila) homolog.
Gene ID: 50846
mRNA Refseq: NM_021044.2
Protein Refseq: NP_066382.1
MIM: 605423
UniProt ID: O43323
Chromosome Location: 12q12-q13.1
Pathway: Hedgehog signaling pathway.
Function: peptidase activity; protein binding.

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