Recombinant Human DHH Protein, GST-tagged

• Cat.No.: DHH-2589H
• Product Overview: Human DHH full-length ORF ( NP_066382.1, 1 a.a. - 396 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes a member of the hedgehog family. The hedgehog gene family encodes signaling molecules that play an important role in regulating morphogenesis. This protein is predicted to be made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the organism. Defects in this protein have been associated with partial gonadal dysgenesis (PGD) accompanied by minifascicular polyneuropathy. This protein may be involved in both male gonadal differentiation and perineurial development. [provided by RefSeq, May 2010]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 70 kDa
• AA Sequence: MALLTNLLPLCCLALLALPAQSCGP GRGPVGRRRYARKQLVPLLYKQFVP GVPERTLGASGPAEGRVARGSERFR DLVPNYNPDIIFKDEENSGADRLMT ERCKERVNALAIAVMNMWPGVRLRV TEGWDEDGHHAQDSLHYEGRALDIT TSDRDRNKYGLLARLAVEAGFDWVY YESRNHVHVSVKADNSLAVRAGGCF PGNATVRLWSGERKGLRELHRGDWV LAADASGRVVPTPVLLFLDRDLQRR ASFVAVETEWPPRKLLLTPWHLVFA ARGPAPAPGDFAPVFARRLRAGDSV LAPGGDALRPARVARVAREEAVGVF APLTAHGTLLVNDVLASCYAVLESH QWAHRAFAPLRLLHALGALLPGGAV QPTGMHWYSRLLYRLAEELLG
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: DHH desert hedgehog [ Homo sapiens ]
• Official Symbol: DHH
• Synonyms: DHH; desert hedgehog; desert hedgehog (Drosophila) homolog; desert hedgehog protein; HHG 3; MGC35145; mutant desert hedgehog; desert hedgehog homolog; GDXYM; HHG-3; SRXY7
• Gene ID: 50846
• mRNA Refseq: NM_021044
• Protein Refseq: NP_066382
• MIM: 605423
• UniProt ID: O43323