"RASSF5" Related Products

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Recombinant Human RASSF5, GST-tagged

Cat. No.: RASSF5-1071H
Description: Nore1 (Novel Ras effector 1) is a non-catalytic 413 amino acid polypeptide that contains several PXXP motifs, a central C1 zinc finger and a Ras-Rap association domain (RA) at its C-terminus. Consistently, Nore1 interacts in a GTP-dependent fashion with a number of Ras-family GTPases, including Ras itself, M-Ras, TC21 and Rap2A. The C-terminal portion of Nore1 exhibits 50 % identity with members of the RASSF Family of putative tumour suppressor proteins. Nore1 mediates the antiproliferative and/or pro-apoptotic effects of Ras in certain cell types, at least partly by activating the MST1 kinase (Mammalian Ste20-like kinase). Recent reports on the epigenetic silencing of Nore1 in a variety of human tumours have made a strong case for a role of Nore1 as a tumour suppressor. Recombinant Human RASSF5 has a molecular weight 47 kDa with GST-tag.
Source: E. coli.
Form: Liquid. Supplied in PBS supplemented with 1 mM EDTA.
Purity: >90% by SDS-PAGE.
Usage: For in vitro use only.
Storage: Quality guaranteed for 12 months store at - 80°C. Avoid freeze / thaw cycles.
Gene Name: RASSF5 Ras association (RalGDS/AF-6) domain family member 5 [ Homo sapiens ]
Synonyms: RASSF5; Ras association (RalGDS/AF-6) domain family member 5; RAPL; Maxp1; NORE1; NORE1A; NORE1B; RASSF3; MGC10823; MGC17344; Ras association domain-containing protein 5; New ras effector 1; Regulator for cell adhesion and polarization enriched in lymphoid tissues; MGC10823; MGC17344; OTTHUMP00000034534; OTTHUMP00000034535; Rap1-binding protein; Ras association (RalGDS/AF-6) domain family 5; Ras effector-like protein; novel Ras effector 1; tumor suppressor RASSF3; Rap1-binding protein
Gene ID: 83593
mRNA Refseq: NM_182663
Protein Refseq: NP_872604
MIM: 607020
UniProt ID: Q8WWW0
Chromosome Location: 1q31
Pathway: Leukocyte transendothelial migration; Non-small cell lung cancer; Pathways in cancer
Function: identical protein binding; metal ion binding; zinc ion binding

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