Recombinant Human RASSF5, GST-tagged
Cat.No. : | RASSF5-1071H |
- Specification
- Gene Information
- Related Products
Cat. No. : | RASSF5-1071H |
Description : | Nore1 (Novel Ras effector 1) is a non-catalytic 413 amino acid polypeptide that contains several PXXP motifs, a central C1 zinc finger and a Ras-Rap association domain (RA) at its C-terminus. Consistently, Nore1 interacts in a GTP-dependent fashion with a number of Ras-family GTPases, including Ras itself, M-Ras, TC21 and Rap2A. The C-terminal portion of Nore1 exhibits 50 % identity with members of the RASSF Family of putative tumour suppressor proteins. Nore1 mediates the antiproliferative and/or pro-apoptotic effects of Ras in certain cell types, at least partly by activating the MST1 kinase (Mammalian Ste20-like kinase). Recent reports on the epigenetic silencing of Nore1 in a variety of human tumours have made a strong case for a role of Nore1 as a tumour suppressor. Recombinant Human RASSF5 has a molecular weight 47 kDa with GST-tag. |
Source : | E. coli. |
Form : | Liquid. Supplied in PBS supplemented with 1 mM EDTA. |
Purity : | >90% by SDS-PAGE. |
Usage : | For in vitro use only. |
Storage : | Quality guaranteed for 12 months store at - 80°C. Avoid freeze / thaw cycles. |
Gene Name : | RASSF5 Ras association (RalGDS/AF-6) domain family member 5 [ Homo sapiens ] |
Synonyms : | RASSF5; Ras association (RalGDS/AF-6) domain family member 5; RAPL; Maxp1; NORE1; NORE1A; NORE1B; RASSF3; MGC10823; MGC17344; Ras association domain-containing protein 5; New ras effector 1; Regulator for cell adhesion and polarization enriched in lymphoid tissues; MGC10823; MGC17344; OTTHUMP00000034534; OTTHUMP00000034535; Rap1-binding protein; Ras association (RalGDS/AF-6) domain family 5; Ras effector-like protein; novel Ras effector 1; tumor suppressor RASSF3; Rap1-binding protein |
Gene ID : | 83593 |
mRNA Refseq : | NM_182663 |
Protein Refseq : | NP_872604 |
MIM : | 607020 |
UniProt ID : | Q8WWW0 |
Chromosome Location : | 1q31 |
Pathway : | Leukocyte transendothelial migration; Non-small cell lung cancer; Pathways in cancer |
Function : | identical protein binding; metal ion binding; zinc ion binding |
Products Types
◆ Recombinant Protein | ||
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RASSF5-7449M | Recombinant Mouse RASSF5 Protein, His (Fc)-Avi-tagged | +Inquiry |
RASSF5-29658TH | Recombinant Human RASSF5, His-tagged | +Inquiry |
RASSF5-29726TH | Recombinant Human RASSF5 | +Inquiry |
RASSF5-13967M | Recombinant Mouse RASSF5 Protein | +Inquiry |
◆ Lysates | ||
RASSF5-2495HCL | Recombinant Human RASSF5 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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