RASSF1

  • Official Full Name

    Ras association (RalGDS/AF-6) domain family member 1

  • Overview

    This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Several alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

  • Synonyms

    RASSF1;Ras association (RalGDS/AF-6) domain family member 1;ras association domain-containing protein 1;123F2;NORE2A;RDA32;REH3P21;Ras association domain containing protein 1;Ras association domain family 1;Ras association domain family protein 1;RASF1_HUMAN;RASSF 1a;RASSF1A;RASSF1A isoform;Tumor suppressor protein RDA32;WUGSC:H_LUCA12.5;OTTHUMP00000195503;OTTHUMP00000195504;OTTHUMP00000195505;OTTHUMP00000195507;cardiac-specific ras association domain family 1 protein;pancreas-specific ras associat
Cat.# Product name Source (Host) Species Tag Protein Length Price
RASSF1-1274Z Recombinant Zebrafish RASSF1 Mammalian Cells Zebrafish His
RASSF1-376H Recombinant Human Ras association (RalGDS/AF-6) domain family member 1, His-tagged E.coli Human His 1-340 a.a.
RASSF1-740H Recombinant Human RASSF1 Mammalian Cells Human His
RASSF1-2499HCL Recombinant Human RASSF1 293 Cell Lysate HEK293 Human Non
RASSF1-3967H Recombinant Human RASSF1 Protein, His (Fc)-Avi-tagged HEK293 Human Avi&Fc&His
RASSF1-3967H-B Recombinant Human RASSF1 Protein Pre-coupled Magnetic Beads HEK293 Human

    Involved Pathway

    RASSF1 involved in several pathways and played different roles in them. We selected most pathways RASSF1 participated on our site, such as Bladder cancer,Hippo signaling pathway,MicroRNAs in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with RASSF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Ras signaling pathway PLA2G5,PLCG1,GRIN1,MAPK9,GNGT2,ARF6,RAC3,RAPGEF5,RRAS2,RGL2
    p53 pathway NEDD8,HUWE1,PPP1R13L,TTC5,TRIM28,CSE1L,CSNK1G3,E4F1,DYRK2,KAT8
    Hippo signaling pathway BMP8A,FZD10,NF2,AXIN2,WTIP,PPP1CA,AXIN1,LEF1,PPP2R2B,CRB2
    Pathways in cancer PTCH1,WNT2,DAPK2,LAMA2,VHL,PRKACB,RAC3,TRAF6,BCL2,TCF7
    Non-small cell lung cancer FHIT,PIK3R2,TP53,PIK3R1,PLCG2,RARB,FOXO3,ALK,TRP53,PDPK1
    Bladder cancer E2F2,RB1,MAP2K2,CDK4,ARAF,RAF1,MAP2K1,CCND1,TP53,IL-8
    MicroRNAs in cancer SOX4,NOTCH4,GLS,TNC,MAP2K1,TPM1,BMI1,KIF23,Pdgfa&Pdgfb,PLAU

    Protein Function

    RASSF1 has several biochemical functions, for example, identical protein binding,protein N-terminus binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RASSF1 itself. We selected most functions RASSF1 had, and list some proteins which have the same functions with RASSF1. You can find most of the proteins on our site.

    Function Related Protein
    protein binding PRPF40A,QKI,C22orf28,COP1,BBS1,GFM2,DNAJC15,TUBA1B,LANCL2,KCNA2
    zinc ion binding USP51,TRIM28,RNF144AA,DZIP3,ZMYM4,ZEB1,TRIM35-28,MEX3C,Adamts19,ADAMDEC1
    identical protein binding P2RX2,SMG9,MRI1,DACT3,IAPP,CLDN10,CXADR,GRIK5,SYT9,G6PDX
    protein N-terminus binding CSNK2A1,TSC1,SMARCC1,SCFD1,NPAT,GLRX,ALG2,PIAS3,YWHAQ,UNC13A

    Interacting Protein

    RASSF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RASSF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RASSF1.

    STK4;STK3;DAXX;SUV39H2

    RASSF1 Related Signal Pathway

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