Recombinant Mouse Ctla4, Fc-His
Cat.No. : | Ctla4-1717M |
Product Overview : | Recombinant Mouse Ctla4 was expressed inNSO cells. The DNA sequence encoding amino acid residues 37 - 162 of the extracellular domain of mouse CTLA-4 was fused to the Fc region of human IgG1 (with IEGR added at the amino-terminus and 6x his-tag added at the carboxy-terminus). |
- Specification
- Gene Information
- Related Products
Cat. No. : | Ctla4-1717M |
Description : | CTLA4 (Cytotoxic T-Lymphocyte Antigen 4) also known as CD152, is a protein which is expressed on the surface of Helper T cells and plays an important regulatory role in the immune system. CTLA4 is a member of the immunoglobulin superfamily, expressed on the surface of Helper T cells. CTLA4 transmits an inhibitory signal to T cells. CTLA4 is potentially therapeutic in auto-immune diseases, such as rheumatoid arthritis, HIV, autoimmune thyroid disease, multiple sclerosis and may also be useful during organ transplantation and cancer treatment. |
Molecular Weight : | The predicted molecular weight of Recombinant Mouse CTLA-4 is Mr 41 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 55 kDa. |
Source : | Mammalian cells |
State Of Matter : | Lyophilized. |
Purity : | >97% by SDS Page and analyzed by silver stain. |
Formulation : | 0.2 μm filtered and lyophilized from PBS. |
Endotoxin : | <1.0 EU/µg as determined by the LAL method. |
Biological Activity : | Measured by its ability to inhibit IL-2 production in Jurkat cells stimulated with 1 μg/ml rhB7-1/Fc in the presence of PHA. The expected ED50 for this effect is 0.1 - 0.4 μg/ml. |
Storage And Stability : | This lyophilized protein is stable for six to twelve months when stored desiccated at -20℃ to -70℃. After aseptic reconstitution, this protein may be stored at 2℃ to 8℃ for one month or at -20℃ to -70℃ in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions. |
Gene Name : | Ctla4 cytotoxic T-lymphocyte-associated protein 4 [ Mus musculus ] |
Synonyms : | Ctla4; cytotoxic T-lymphocyte-associated protein 4; Cd152; Ly-56; Ctla-4; CD152 antigen; OTTMUSP00000002168 |
Gene ID : | 12477 |
mRNA Refseq : | NM_009843 |
Protein Refseq : | NP_033973 |
UniProt ID : | P09793 |
Chromosome Location : | 1 C; 1 30.1 cM |
Pathway : | Autoimmune thyroid disease; Cell adhesion molecules (CAMs); T cell receptor signaling pathway |
Products Types
◆ Recombinant Protein | ||
CTLA4-647C | Recombinant Cynomolgus monkey CTLA4 Protein | +Inquiry |
CTLA4-2075H | Recombinant Human CTLA4 Protein, GST-tagged | +Inquiry |
Ctla4-650H | Recombinant Human Ctla4 Protein, Fc-tagged | +Inquiry |
CTLA4-656R | Recombinant Rabbit CTLA4 Protein, Fc-tagged | +Inquiry |
CTLA4-257H | Active Recombinant Human CTLA4 Protein, His-Avi-tagged, Biotinylated | +Inquiry |
◆ Lysates | ||
CTLA4-2526HCL | Recombinant Human CTLA4 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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