Ctla4 Protein

Ctla4

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Ctla4

Official Full Name Ctla4 cytotoxic T-lymphocyte-associated protein 4
Background CD152 is a 33 kD member of the immunoglobulin superfamily also known as CTLA-4 or Ly-56. It is expressed on activated T and B lymphocytes. CD152 is similar to CD28 in amino acid sequence, structure, and genomic organization and these two receptors share common B7 family counter-receptors (B7-1, B7-2). Whereas CD28 delivers a costimulatory signal in T cell activation, CTLA-4 negatively regulates cellmediated immune responses. CD152 is thought to play a role in the induction and maintenance of immunological tolerance, as well as the development of protective immunity and thymocyte regulation.
Synonyms CD; GSE; GRD4; ICOS; CD152; CTLA-4; IDDM12; CELIAC3; cytotoxic T-lymphocyte protein 4; CD152 isoform; celiac disease 3; cytotoxic T-lymphocyte antigen 4; cytotoxic T-lymphocyte-associated antigen 4; cytotoxic T-lymphocyte-associated serine esterase-4; cytotoxic T lymphocyte associated antigen 4 short spliced form; ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4; Ipilimumab; Yervoy; 477202-00-9; Ticilimumab (= tremelimumab); 745013-59-6
    • Species :
    • Bovine
    • Canine
    • Chicken
    • Cynomolgus
    • Cynomolgus Monkey
    • Cynomolgus/Rhesus
    • Cynomolgus/Rhesus macaque
    • Dog
    • Homo sapiens (Human)
    • Human
    • Monkey
    • Mouse
    • Mus musculus (Mouse)
    • Oryctolagus cuniculus (Rabbit)
    • Rabbit
    • Rat
    • Rhesus Macaque
    • Source :
    • CHO
    • E.coli
    • E.coli expression system
    • Hamster
    • HEK293
    • HEK293 cells
    • Human Cell
    • Human Cells
    • Insect Cell
    • Mammalian Cell
    • Mammalian cells
    • NS1
    • Sf21 Insect Cell
    • Sf9 Insect Cell
    • Wheat Germ
    • Yeast
    • Tag :
    • APC
    • Avi
    • Fc
    • DDK
    • His
    • DYKDDDDK
    • Fc/Avi
    • Fc/His
    • GST
    • hFc
    • hIgG/His
    • HIgG1 Fc
    • Flag
    • StrepII
    • HIgG
    • T7
    • His-SUMO & Myc
    • HlgG1 Fc
    • human
    • IgG1
    • Mouse
    • IgG2a
    • N/A
    • N-His&GST
    • N-His&SUMO
    • Twin Strep
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CTLA4-160H Active Recombinant Human CTLA4, Fc-tagged CHO Fc
    Human CTLA4-2235H Active Recombinant Human CTLA4 protein, Twin Strep-tagged HEK293 Twin Strep
    Human CTLA4-3256H Active Recombinant Human CTLA4, MIgG2a Fc-tagged NS1 Fc
    Human CTLA4-3258H Active Recombinant Human CTLA4, HIgG1 Fc-tagged, mutant CHO Fc
    Human CTLA4-593H Active Recombinant Human CTLA4, Fc-tagged, Biotinylated Human Cell Fc
    Mouse Ctla4-333M Active Recombinant Mouse Ctla4, MIgG2a Fc-tagged, mutant NS1 Fc
    Mouse Ctla4-4556M Active Recombinant Mouse Ctla4, MIgG2a Fc-tagged NS1 Fc
    Cynomolgus CTLA4-109C Active Recombinant Cynomolgus CTLA4 protein, His-tagged HEK293 His
    Cynomolgus Monkey CTLA4-192C Active Recombinant Cynomolgus Monkey CTLA4 protein, Fc-tagged HEK293 Fc
    Cynomolgus/Rhesus CTLA4-354C Active Recombinant Cynomolgus/Rhesus CTLA4 protein, His-tagged HEK293 His
    Cynomolgus CTLA4-8852C Active Recombinant Cynomolgus CTLA4 protein, Fc-tagged HEK293 Fc
    Human CTLA4-01H Active Recombinant Human CTLA4 Protein, His-Tagged Insect Cell His
    Human CTLA4-051H Active Recombinant Human CTLA4 protein, Fc/Avi-tagged, Biotinylated HEK293 cells Fc/Avi
    Monkey CTLA4-109CAF488 Active Recombinant Cynomolgus CTLA4 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His
    Monkey CTLA4-109CAF555 Active Recombinant Cynomolgus CTLA4 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His
    Monkey CTLA4-109CAF647 Active Recombinant Cynomolgus CTLA4 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His
    Monkey CTLA4-109CF Active Recombinant Cynomolgus CTLA4 Protein, His-tagged, FITC conjugated HEK293 His
    Cynomolgus/Rhesus CTLA4-356C Active Recombinant Cynomolgus/Rhesus CTLA4 protein, His-tagged HEK293 His
    Monkey CTLA4-8852CAF488 Active Recombinant Monkey CTLA4 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc
    Monkey CTLA4-8852CAF555 Active Recombinant Monkey CTLA4 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc
    Monkey CTLA4-8852CAF647 Active Recombinant Monkey CTLA4 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc
    Monkey CTLA4-8852CF Active Recombinant Monkey CTLA4 Protein, Fc-tagged, FITC conjugated HEK293 Fc
    Human CTLA4-137H Recombinant Humancytotoxic T-lymphocyte-Associated Protein 4 Sf9 Insect Cell N/A
    Human CTLA4-1598H Recombinant Human Cytotoxic T-lymphocyte-associated Protein 4, Fc-His Sf21 Insect Cell Fc/His
    Human CTLA4-1913H Recombinant Human CTLA4, Fc Chimera E.coli Fc
    Human CTLA4-2073P Recombinant CTLA4 Protein, His-Flag-StrepII-tagged Human Cell His/Flag/StrepII
    Human CTLA4-2075H Recombinant Human CTLA4 Protein, GST-tagged Wheat Germ GST
    Human CTLA4-2232H Recombinant Human CTLA4 protein, His-tagged HEK293 His
    Human CTLA4-2233H Recombinant Human CTLA4, Fc-His tagged Human Cell Fc/His
    Human CTLA4-2234H Recombinant Human CTLA4 protein, Fc-tagged HEK293 human/IgG1/Fc
    Human CTLA4-228H Recombinant Human CTLA4, C13&N15-labeled HEK293 N/A
    Human CTLA4-255H Recombinant Human CTLA4, His-tagged, Biotinylated HEK293 His
    Human CTLA4-256H Recombinant Human CTLA4 protein, Fc/Avi-tagged, Biotinylated HEK293 Avi/Fc
    Human CTLA4-28029TH Recombinant Human CTLA4, Fc-tagged Fc
    Human CTLA4-344H Recombinant Human CTLA4 Protein, DDK/His-tagged HEK293 DDK/His
    Human CTLA4-54H Recombinant Human CTLA4 protein, His-tagged Insect Cell His
    Human CTLA4-7259H Recombinant Human CTLA4, His-tagged E.coli His
    Mouse Ctla4-1717M Recombinant Mouse Ctla4, Fc-His Mammalian cells Fc/His
    Mouse Ctla4-3261M Recombinant Mouse Ctla4 protein, Fc-tagged HEK293 human/IgG1/Fc
    Mouse Ctla4-3307M Recombinant Mouse Ctla4 protein, His-tagged HEK293 His
    Mouse Ctla4-41M Recombinant Mouse Ctla4 Protein, hIgG-His-tagged Insect Cell His/HIgG
    Mouse Ctla4-4557M Recombinant Mouse Ctla4 protein, mouse IgG2a Fc-tagged, low endotoxin HEK293 Mouse/IgG2a/Fc
    Mouse Ctla4-5839M Recombinant Mouse Ctla4 protein, His & T7-tagged E.coli His/T7
    Rat Ctla4-1143R Recombinant Rat Ctla4 protein, Fc-tagged HEK293 human/IgG1/Fc
    Rat Ctla4-1144R Recombinant Rat Ctla4 Protein, His-tagged HEK293 His
    Rat Ctla4-5840R Recombinant Rat Ctla4 protein, His & T7-tagged E.coli His/T7
    Rhesus Macaque CTLA4-1077R Recombinant Rhesus monkey CTLA4 Protein, His-tagged Mammalian Cell His
    Canine CTLA4-1060C Recombinant Canine CTLA4 Protein, Fc-tagged HEK293 Fc
    Canine CTLA4-1061C Recombinant Canine CTLA4 Protein, His-tagged HEK293 His
    Chicken CTLA4-3408C Recombinant Chicken CTLA4 Mammalian Cell His
    Human CTLA4-2526HCL Recombinant Human CTLA4 cell lysate Human Cell N/A
    Mouse CTLA4-2179MCL Recombinant Mouse CTLA4 cell lysate Human Cell N/A
    Cynomolgus Monkey CTLA4-1047CCL Recombinant Cynomolgus CTLA4 cell lysate Human Cell N/A
    Mouse Ctla4-06M Recombinant Mouse Ctla4 Protein, hIgG/His-tagged Insect Cell hIgG/His
    Dog CTLA4-1060CAF488 Recombinant Canine CTLA4 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc
    Dog CTLA4-1060CAF555 Recombinant Canine CTLA4 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc
    Dog CTLA4-1060CAF647 Recombinant Canine CTLA4 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc
    Dog CTLA4-1060CF Recombinant Canine CTLA4 Protein, Fc-tagged, FITC conjugated HEK293 Fc
    Dog CTLA4-1061CAF488 Recombinant Canine CTLA4 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His
    Dog CTLA4-1061CAF555 Recombinant Canine CTLA4 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His
    Dog CTLA4-1061CAF647 Recombinant Canine CTLA4 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His
    Dog CTLA4-1061CF Recombinant Canine CTLA4 Protein, His-tagged, FITC conjugated HEK293 His
    Rat Ctla4-1143RAF488 Recombinant Rat Ctla4 Protein, hFc-tagged, Alexa Fluor 488 conjugated HEK293 hFc
    Rat Ctla4-1143RAF555 Recombinant Rat Ctla4 Protein, hFc-tagged, Alexa Fluor 555 conjugated HEK293 hFc
    Rat Ctla4-1143RAF647 Recombinant Rat Ctla4 Protein, hFc-tagged, Alexa Fluor 647 conjugated HEK293 hFc
    Rat Ctla4-1143RF Recombinant Rat Ctla4 Protein, hFc-tagged, FITC conjugated HEK293 hFc
    Rat Ctla4-1144RAF488 Recombinant Rat Ctla4 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His
    Rat Ctla4-1144RAF555 Recombinant Rat Ctla4 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His
    Rat Ctla4-1144RAF647 Recombinant Rat Ctla4 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His
    Rat Ctla4-1144RF Recombinant Rat Ctla4 Protein, His-tagged, FITC conjugated HEK293 His
    Human CTLA4-152H Recombinant Human CTLA4 Protein, DYKDDDDK-tagged Human Cells DYKDDDDK
    Human CTLA4-2232HAF488 Recombinant Human CTLA4 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His
    Human CTLA4-2232HAF555 Recombinant Human CTLA4 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His
    Human CTLA4-2232HAF647 Recombinant Human CTLA4 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His
    Human CTLA4-2232HF Recombinant Human CTLA4 Protein, His-tagged, FITC conjugated HEK293 His
    Human CTLA4-2233HAF488 Recombinant Human CTLA4 Protein, Fc/His-tagged, Alexa Fluor 488 conjugated HEK293 Fc/His
    Human CTLA4-2233HAF555 Recombinant Human CTLA4 Protein, Fc/His-tagged, Alexa Fluor 555 conjugated HEK293 Fc/His
    Human CTLA4-2233HAF647 Recombinant Human CTLA4 Protein, Fc/His-tagged, Alexa Fluor 647 conjugated HEK293 Fc/His
    Human CTLA4-2233HF Recombinant Human CTLA4 Protein, Fc/His-tagged, FITC conjugated HEK293 Fc/His
    Human CTLA4-2754H Recombinant Human CTLA4 protein, His-tagged E.coli His
    Mouse Ctla4-2755M Recombinant Mouse Ctla4 protein, His-SUMO & Myc-tagged E.coli His-SUMO & Myc
    Human CTLA4-301345H Recombinant Human CTLA4 protein, GST-tagged E.coli GST
    Mouse Ctla4-3261MAF488 Recombinant Mouse Ctla4 Protein, hFc-tagged, Alexa Fluor 488 conjugated HEK293 hFc
    Mouse Ctla4-3261MAF555 Recombinant Mouse Ctla4 Protein, hFc-tagged, Alexa Fluor 555 conjugated HEK293 hFc
    Mouse Ctla4-3261MAF647 Recombinant Mouse Ctla4 Protein, hFc-tagged, Alexa Fluor 647 conjugated HEK293 hFc
    Mouse Ctla4-3261MF Recombinant Mouse Ctla4 Protein, hFc-tagged, FITC conjugated HEK293 hFc
    Mouse Ctla4-3307MAF488 Recombinant Mouse Ctla4 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His
    Mouse Ctla4-3307MAF555 Recombinant Mouse Ctla4 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His
    Mouse Ctla4-3307MAF647 Recombinant Mouse Ctla4 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His
    Mouse Ctla4-3307MF Recombinant Mouse Ctla4 Protein, His-tagged, FITC conjugated HEK293 His
    Human CTLA4-869H Recombinant Human CTLA4 Protein, His&GST-tagged E.coli N-His&GST
    Human CTLA4-870H Recombinant Human CTLA4 Protein, His&SUMO-tagged E.coli N-His&SUMO
    Homo sapiens (Human) RFL18315HF Recombinant Full Length Human Cytotoxic T-Lymphocyte Protein 4(Ctla4) Protein, His-Tagged E.coli expression system His
    Oryctolagus cuniculus (Rabbit) RFL22810OF Recombinant Full Length Rabbit Cytotoxic T-Lymphocyte Protein 4(Ctla4) Protein, His-Tagged E.coli expression system His
    Mus musculus (Mouse) RFL2295MF Recombinant Full Length Mouse Cytotoxic T-Lymphocyte Protein 4(Ctla4) Protein, His-Tagged E.coli expression system His
    Human CTLA4-1106H Recombinant Human CTLA4 Protein (Met1-Phe162), HlgG1 Fc-tagged, Biotinylated HEK293 HlgG1 Fc
    Human CTLA4-135HG GMP Recombinant Human CTLA4 protein, His-tagged HEK293 His
    Human CTLA4-155HG GMP Recombinant Human CTLA4 Protein HEK293 Fc
    Human CTLA4-257H Recombinant Human CTLA4 Protein, His-Avi-tagged, Biotinylated HEK293 His/Avi
    Human CTLA4-371H Recombinant Human CTLA4 protein, mouse IgG2a Fc-tagged, low endotoxin HEK293 Mouse/IgG2a/Fc
    Human CTLA4-499H Recombinant Human CTLA4 Protein (Met1-Phe162), HIgG1 Fc-tagged HEK293 HIgG1 Fc
    Human CTLA4-500H Recombinant Human CTLA4 Protein (Met1-Asp161) HEK293 N/A
    Human CTLA4-862H Recombinant Human CTLA4 protein, His-tagged, low endotoxin HEK293 His
    Human CTLA4-8722H Recombinant Human CTLA4 protein, His-tagged (MALS verified) HEK293 His
    Human CTLA4-P03H Recombinant Human CTLA4, Fc-tagged therapeutic protein CHO Fc
    Mouse Ctla4-038M Recombinant Mouse Ctla4 Protein, Fc-tagged CHO Fc
    Mouse Ctla4-3307MB Recombinant Mouse Ctla4 protein, His-tagged, Biotinylated HEK293 His
    Mouse CTLA4-3358M Recombinant Mouse CTLA4 Protein, Fc-tagged CHO Fc
    Mouse Ctla4-7168M Recombinant Mouse Ctla4 Protein, hIgG-His-tagged HIgG/His
    Mouse DMABT-H18898 Hamster Anti-CTLA4 Monoclonal Antibody Hamster APC
    Bovine CTLA4-4413B Recombinant Bovine CTLA4 Protein Yeast N/A
    Rabbit CTLA4-372R Recombinant Rabbit CTLA4 protein, Fc-tagged HEK293 human/IgG1/Fc
    Cynomolgus/Rhesus macaque CTLA4-369C Recombinant Cynomolgus/Rhesus macaque CTLA4 protein, His-tagged HEK293 His
    Cynomolgus/Rhesus macaque CTLA4-370C Recombinant Cynomolgus/Rhesus macaque CTLA4 protein, Fc-tagged HEK293 human/IgG1/Fc
    Kit-1712 CTLA4:B7-1[Biotinylated] Inhibitor Screening Assay Kit N/A
    Kit-1713 CTLA4[Biotinylated]:B7-2 Inhibitor Screening Assay Kit N/A

    Ctla4 involved in several pathways and played different roles in them. We selected most pathways Ctla4 participated on our site, such as Adaptive Immune System, Autoimmune thyroid disease, CTLA4 inhibitory signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with Ctla4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Adaptive Immune System RNF25; CTSS; HECTD3; MAP3K8; CD300LD; AP1S3A; KIF3C; KLC3; GRAP2B; SIGLEC9
    Autoimmune thyroid disease CGA; IFN-a; CTLA4; OSTN; IL10
    CTLA4 inhibitory signaling CTLA4
    Calcineurin-regulated NFAT-dependent transcription in lymphocytes CDK4; JUNB; BATF3; IRF4; EGR3; POU2F1; IKZF1; CTLA4; EGR1; EGR2
    Cell adhesion molecules (CAMs) NLGN3A; PTPRM; NRXN2; SELL; ICAM3; NTNG1; CLDN15; CD80; LRRC4C; MADCAM1
    Costimulation by the CD28 family MAPKAP1; CTLA4; CSK; MAP3K8; HLA-DQB2; THEM4; PDPK1A; BTLA
    Immune System UBE2E3; AP1B1; BTR02; SOCS3A; SUGT1; HCST; ASB8; KIF3B; LILRB2; CRP
    Rheumatoid arthritis HLA-DOB; TNF; HLA-DQA1; ATP6V1F; CXCL1; HLA-DPA1; MMP1A; IL1B; IL-8; ATP6V0A4

    Ctla4 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Ctla4 itself. We selected most functions Ctla4 had, and list some proteins which have the same functions with Ctla4. You can find most of the proteins on our site.

    Function Related Protein
    protein binding CSRNP2; PDE6G; SPRED2; CCDC106; ABTB1; AP1M1; PPP1R15B; RTN4RL1B; PAX9; ZNF747

    Ctla4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Ctla4 here. Most of them are supplied by our site. Hope this information will be useful for your research of Ctla4.

    CD86; PIK3R1; CD80; FYN; STAT5A; STAT5B; RAPGEF1; RAB8A; TRIM25; LAX1

    Venditti, O; De Lisi, D; et al. Ipilimumab and immune-mediated adverse events: a case report of anti-CTLA4 induced ileitis. BMC CANCER 15:-(2015).
    Garin, EH; Reiser, J; et al. Case series: CTLA4-IgG1 therapy in minimal change disease and focal segmental glomerulosclerosis. PEDIATRIC NEPHROLOGY 30:469-477(2015).

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