|Official Full Name||Ctla4 cytotoxic T-lymphocyte-associated protein 4|
|Background||CD152 is a 33 kD member of the immunoglobulin superfamily also known as CTLA-4 or Ly-56. It is expressed on activated T and B lymphocytes. CD152 is similar to CD28 in amino acid sequence, structure, and genomic organization and these two receptors share common B7 family counter-receptors (B7-1, B7-2). Whereas CD28 delivers a costimulatory signal in T cell activation, CTLA-4 negatively regulates cellmediated immune responses. CD152 is thought to play a role in the induction and maintenance of immunological tolerance, as well as the development of protective immunity and thymocyte regulation.|
|Synonyms||CD; GSE; GRD4; ICOS; CD152; CTLA-4; IDDM12; CELIAC3; cytotoxic T-lymphocyte protein 4; CD152 isoform; celiac disease 3; cytotoxic T-lymphocyte antigen 4; cytotoxic T-lymphocyte-associated antigen 4; cytotoxic T-lymphocyte-associated serine esterase-4; cytotoxic T lymphocyte associated antigen 4 short spliced form; ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4; Ipilimumab; Yervoy; 477202-00-9; Ticilimumab (= tremelimumab); 745013-59-6|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
Ctla4 involved in several pathways and played different roles in them. We selected most pathways Ctla4 participated on our site, such as Adaptive Immune System, Autoimmune thyroid disease, CTLA4 inhibitory signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with Ctla4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Adaptive Immune System||RNF25; CTSS; HECTD3; MAP3K8; CD300LD; AP1S3A; KIF3C; KLC3; GRAP2B; SIGLEC9|
|Autoimmune thyroid disease||CGA; IFN-a; CTLA4; OSTN; IL10|
|CTLA4 inhibitory signaling||CTLA4|
|Calcineurin-regulated NFAT-dependent transcription in lymphocytes||CDK4; JUNB; BATF3; IRF4; EGR3; POU2F1; IKZF1; CTLA4; EGR1; EGR2|
|Cell adhesion molecules (CAMs)||NLGN3A; PTPRM; NRXN2; SELL; ICAM3; NTNG1; CLDN15; CD80; LRRC4C; MADCAM1|
|Costimulation by the CD28 family||MAPKAP1; CTLA4; CSK; MAP3K8; HLA-DQB2; THEM4; PDPK1A; BTLA|
|Immune System||UBE2E3; AP1B1; BTR02; SOCS3A; SUGT1; HCST; ASB8; KIF3B; LILRB2; CRP|
|Rheumatoid arthritis||HLA-DOB; TNF; HLA-DQA1; ATP6V1F; CXCL1; HLA-DPA1; MMP1A; IL1B; IL-8; ATP6V0A4|
Ctla4 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Ctla4 itself. We selected most functions Ctla4 had, and list some proteins which have the same functions with Ctla4. You can find most of the proteins on our site.
|protein binding||CSRNP2; PDE6G; SPRED2; CCDC106; ABTB1; AP1M1; PPP1R15B; RTN4RL1B; PAX9; ZNF747|
Ctla4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Ctla4 here. Most of them are supplied by our site. Hope this information will be useful for your research of Ctla4.
CD86; PIK3R1; CD80; FYN; STAT5A; STAT5B; RAPGEF1; RAB8A; TRIM25; LAX1