Recombinant Human GREM1
Cat.No. : | GREM1-28484TH |
Product Overview : | Recombinant full length Human Gremlin 1 ; 20.6kDa; O60565 |
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Description : | This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to relay the sonic hedgehog (SHH) signal from the polarizing region to the apical ectodermal ridge during limb bud outgrowth. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
Protein length : | 160 amino acids |
Molecular Weight : | 18.400kDa |
Source : | E. coli |
Tissue specificity : | Highly expressed in small intestine, fetal brain and colon. Weakly expressed in brain, ovary, prostate, pancreas and skeletal muscle. In brain found in the region localized around the internal capsule in the large subcortical nuclei, including caudate, pu |
Form : | Liquid |
Purity : | by SDS-PAGE |
Storage buffer : | Constituent:0.3% Acetic acid |
Storage : | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. |
Sequences of amino acids : | MKKKGSQGAIPPPDKAQHNDSEQTQ SPQQPGSRNRGRGQGRGTAMPGEEV LESSQEALHVTERKYLKRDWCKTQP LKQTIHEEGCNSRTIINRFCYGQCN SFYIPRHIRKEEGSFQSCSFCKPKK FTTMMVTLNCPELQPPTKKKRVTRV KQCRCISIDLD |
Sequence Similarities : | Belongs to the DAN family.Contains 1 CTCK (C-terminal cystine knot-like) domain. |
Gene Name : | GREM1 gremlin 1 [ Homo sapiens ] |
Official Symbol : | GREM1 |
Synonyms : | GREM1; gremlin 1; CKTSF1B1, cysteine knot superfamily 1, BMP antagonist 1 , gremlin 1, cysteine knot superfamily, homolog (Xenopus laevis); gremlin-1; DAND2; DRM; gremlin; |
Gene ID : | 26585 |
mRNA Refseq : | NM_001191322 |
Protein Refseq : | NP_001178251 |
MIM : | 603054 |
Uniprot ID : | O60565 |
Chromosome Location : | 15q13.3 |
Pathway : | BMP receptor signaling, organism-specific biosystem; |
Function : | cytokine activity; protein binding; |
Products Types
◆ Recombinant Protein | ||
GREM1-5321H | Recombinant Human GREM1 Protein, GST-tagged | +Inquiry |
GREM1-2342R | Recombinant Rat GREM1 Protein, His (Fc)-Avi-tagged | +Inquiry |
GREM1-494H | Recombinant Human GREM1 Protein | +Inquiry |
Grem1-316R | Recombinant Rat Grem1 Protein, His-tagged | +Inquiry |
GREM1-2215H | Recombinant Human GREM1 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
GREM1-001MCL | Recombinant Mouse GREM1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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