"THPO" Related Products

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Recombinant Human Thrombopoietin

Cat. No.: THPO-175H
Description: Thrombopoietin (leukemia virus oncogene ligand, megakaryocyte growth and development factor), also known as THPO is a lineage-dominant hematopoietic cytokine. TPO is a glycoprotein hormone constitutively produced mainly by the liver and kidney and is the primary physiological regulator megakaryopoiesis and platelet production.
Source: Sf 21 Insect Cells.
Molecular Weight: The predicted molecular weight of Recombinant Human TPO is Mr 35 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 47 kDa.
State Of Matter: Lyophilized.
Biological Activity: The biological activity of Human Thrombopoietin is determined by the dose-dependent stimulation of the proliferation of human MO7e cells. The expected ED50 for this effect is 1.0-3.0 ng/ml.
Purity: >97% by SDS Page and analyzed by silver stain.
Endotoxin: <1.0 EU/µg as determined by the LAL method.
Storage And Stability: This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Gene Name: THPO thrombopoietin [ Homo sapiens ]
Synonyms: thrombopoietin nirs variant 1; megakaryocyte stimulating factor; MKCSF; c-mpl ligand; megakaryocyte colony-stimulating factor; MGDF; megakaryocyte growth and development factor; MPL ligand; myeloproliferative leukemia virus oncogene ligand; C-mpl ligand; Megakaryocyte colony-stimulating factor; Megakaryocyte growth and development factor; MGC163194; Myeloproliferative leukemia virus oncogene ligand; Thrombopoietin; ML; TPO; MPLLG; THPO
Gene ID: 7066
mRNA Refseq: NM_000460
Protein Refseq: NP_000451
MIM: 600044
UniProt ID: P40225
Chromosome Location: 3q27
Pathway: Hematopoietic cell lineage
Function: cytokine activity; growth factor activity; hormone activity

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