THPO

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THPO

Official Full Name thrombopoietin
Background Megakaryocytopoiesis is the cellular development process that leads to platelet production. The main functional protein encoded by this gene is a humoral growth factor that is necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. This protein is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene. Mutations in this gene are the cause of thrombocythemia 1. Alternative promoter usage and differential splicing result in multiple transcript variants differing in the 5 UTR and/or coding region. Multiple AUG codons upstream of the main open reading frame (ORF) have been identified, and these upstream AUGs inhibit translation of the main ORF at different extent. [provided by RefSeq, Feb 2014]
Synonyms THPO; thrombopoietin; ML; TPO; MGDF; MKCSF; MPLLG; THCYT1; MPL ligand; c-mpl ligand; prepro-thrombopoietin; megakaryocyte stimulating factor; megakaryocyte colony-stimulating factor; megakaryocyte growth and development factor; myeloproliferative leukemia virus oncogene ligand;
    • Species :
    • Bovine
    • Chicken
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • CHO
    • E. coli
    • E.coli
    • HEK293
    • Human
    • Human Cell
    • Mammalian Cell
    • Mammalian cells
    • Sf21 Insect Cell
    • Yeast
    • Tag :
    • Fc
    • His
    • GST
    • T7
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human THPO-001HCL Recombinant Human THPO cell lysate CHO N/A
    Human THPO-13H Recombinant Human Thrombopoietin Reference standard N/A
    Human THPO-1533H Recombinant Human Thrombopoietin HEK293 N/A
    Human THPO-175H Recombinant Human Thrombopoietin Sf21 Insect Cell N/A
    Human THPO-176H Recombinant Human Thrombopoietin Mammalian cells N/A
    Human THPO-216H Recombinant Human THPO Protein, His-tagged HEK293 His
    Human THPO-216HB Recombinant Human THPO protein, His-tagged, Biotinylated HEK293 His
    Human THPO-269H Recombinant Human Thrombopoietin Human N/A
    Human THPO-26H Recombinant Human Thrombopoietin Mammalian Cell N/A
    Human THPO-27H Recombinant Human Thrombopoietin HEK293 N/A
    Human THPO-2832HCL Recombinant Human THPO cell lysate Human Cell N/A
    Human THPO-29520TH Recombinant Human THPO E.coli N/A
    Human THPO-432HG GMP Recombinant Human THPO protein, Fc-tagged HEK293 Fc
    Human THPO-573H Recombinant Human THPO protein, His & GST-tagged E.coli His/GST
    Human THPO-80H Recombinant Human THPO, His-tagged Human Cell His
    Human THPO-81H Recombinant Human THPO, Fc-tagged Human Cell Fc
    Human THPO-82H Recombinant Human Thrombopoietin HEK293 N/A
    Human THPO-861H Recombinant Human THPO, His tagged CHO His
    Human THPO-98H Recombinant Human Thrombopoietin, His-tagged HEK293 His
    Human THPO-99H Recombinant Human THPO protein, His-tagged HEK293 His
    Human THPO-P02H Recombinant Human THPO, Fc-tagged therapeutic protein E.coli Fc
    Mouse Thpo-1531M Recombinant Mouse Thpo protein E.coli N/A
    Mouse Thpo-177M Recombinant Mouse Thrombopoietin Mammalian cells N/A
    Mouse Thpo-1782M Recombinant Mouse Thrombopoietin, Fc Chimera Mammalian cells Fc
    Mouse THPO-2831MCL Recombinant Mouse THPO cell lysate Human Cell N/A
    Mouse Thpo-556MG GMP Recombinant Mouse Thpo protein, His-tagged HEK293 His
    Mouse Thpo-6417M Recombinant Mouse Thpo Protein CHO
    Mouse Thpo-6418M Recombinant Mouse Thpo Protein E. coli
    Mouse Thpo-895M Recombinant Mouse Thpo Protein CHO N/A
    Mouse Thpo-97M Recombinant Mouse Thpo, His tagged Human Cell His
    Rat Thpo-575R Recombinant Rat Thpo protein, His & T7-tagged E.coli His/T7
    Rat THPO-6057R Recombinant Rat THPO Protein Mammalian Cell His
    Rat Thpo-891R Recombinant Rat Thpo Protein E.coli N/A
    Cynomolgus Monkey THPO-1163C Recombinant Cynomolgus THPO Protein, His-tagged HEK293 His
    Cynomolgus Monkey THPO-2273CCL Recombinant Cynomolgus THPO cell lysate Human Cell N/A
    Bovine THPO-4327B Recombinant Bovine THPO Protein Yeast N/A
    Chicken THPO-1175C Recombinant Chicken THPO Mammalian Cell His
    Zebrafish THPO-7258Z Recombinant Zebrafish THPO Mammalian Cell His

    THPO involved in several pathways and played different roles in them. We selected most pathways THPO participated on our site, such as Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Hematopoietic cell lineage, which may be useful for your reference. Also, other proteins which involved in the same pathway with THPO were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interaction GHRA; IFNA7; IL29; VEGFA; CSF2RA; IL10; TNFRSF11B; IFNA16; BMP7A; VEGFB
    Jak-STAT signaling pathway IL3; SOCS3; SOCS9; IL21R.1; PTPN2; TP-1; OSMR; Ifnlr1; PIAS4A; PIK3R5
    Hematopoietic cell lineage IL11RA2; IL5RA; TFRC; CD4; IL3RA; CD2; Itga10&Itgb1; CSF3R; HLA-DRB3; Il6ra

    THPO has several biochemical functions, for example, cytokine activity, growth factor activity, hormone activity. Some of the functions are cooperated with other proteins, some of the functions could acted by THPO itself. We selected most functions THPO had, and list some proteins which have the same functions with THPO. You can find most of the proteins on our site.

    Function Related Protein
    cytokine activity BMP2B; SPAW; BMP3; GPR19; IL23; IL37; CLCF1; Fasl; BMP2; FAM3D
    growth factor activity GDF5; PDGFD; LACRT; JAG2; FGF7; GDNF; FGF1A; GDF1; NTF3; BMP8A
    hormone activity UTS2D; GPHB5; GH1; ADIPOQ; INS; IGF2; LEPB; PRL2C2; C1QTNF9; MLN

    THPO has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with THPO here. Most of them are supplied by our site. Hope this information will be useful for your research of THPO.

    EP300; APH1A; NUMBL

    Kuter, DJ; et al. Milestones in understanding platelet production: a historical overview. BRITISH JOURNAL OF HAEMATOLOGY 165:248-258(2014).
    Arai, F; Yoshihara, H; et al. Niche Regulation of Hematopoietic Stem Cells in the Endosteum The Role of Thrombopoietin/Mp1 Signaling in the Maintenance of Quiescent Hematopoietic Stem Cells. HEMATOPOIETIC STEM CELLS VII 1176:36-46(2009).

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