||Recombinant human Xeno-free TGF beta 3 is expressed fromhuman 293 cellsas a mature disulfide-linked homodimer with apparent molecular mass of 25 kDa.
||Transforming growth factor beta-3 is a protein that in humans is encoded by the TGFB3 gene. It has been shown to interact with TGF beta receptor 2. This cytokine is produced in a human cell expression system with serum-free, chemically defined media. The cytokine is greater than 95% pure.
||Human 293 cells.
||0.1 to 0.5 ng/mL ED50.
||The protein was resolved by SDS polyacrylamide gel electrophoresis and the gel was stained with Coomassie blue.
||The specific activity was determined by the dose-dependent inhibition of IL-4 induced proliferation of mouse HT-2 cells (BALB/c spleen activated by sheep erythrocytes in the presence of IL-2).
||Cell cycle; Chronic myeloid leukemia; Colorectal cancer; Cytokine-cytokine receptor interaction; Hypertrophic cardiomyopathy (HCM); MAPK signaling pathway; Pancreatic cancer;Pathways in cancer; Renal cell carcinoma; TGF-beta signaling pathway