TGFB3
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Official Full Name
transforming growth factor, beta 3
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Overview
This gene encodes a member of the TGF-beta family of proteins. The encoded protein is secreted and is involved in embryogenesis and cell differentiation. Defects in this gene are a cause of familial arrhythmogenic right ventricular dysplasia 1. -
Synonyms
TGFB3; transforming growth factor, beta 3; ARVD; FLJ16571; TGF-beta3; transforming growth factor beta-3; TGF-beta-3; MGC105479; MGC118722; TGF beta 3; TGF beta3; TGFB 3; TGFB3_HUMAN; transforming growth factor beta 3; OTTHUMP00000246179; OTTHUMP00000246180;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- GMP Proteins
- Transfected Stable Cell Lines
- Ala301-Ser412
- Bovine
- Cattle
- Chicken
- Human
- Human/Mouse
- Mouse
- Pig
- Rabbit
- Rat
- Rhesus Macaque
- Zebrafish
- C-Avi
- CHO
- CHO Cells
- E. coli
- E.coli
- HEK293
- HEK293T
- Human Cell
- Human cells
- Insect Cell
- Mammalian Cell
- Mammalian cells
- Nicotiana Benthamiana
- Sf21 Insect Cell
- Biotin
- C
- His
- Fc
- Flag
- Avi
- GST
- SUMO
- T7
- Myc
- DDK
- N
- Non
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
- TGFB3 Related Signal Pathway
TGFB3 involved in several pathways and played different roles in them. We selected most pathways TGFB3 participated on our site, such as MAPK signaling pathway, Cytokine-cytokine receptor interaction, FoxO signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TGFB3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MAPK signaling pathway | CASP3A;PPP3R2;GADD45BA;CACNA1G;RAF1A;PPM1NA;FGFR2;CACNA2D4;C11orf52 |
| Cytokine-cytokine receptor interaction | TNFRSF9A;Il23a;CCR6;CXCR3.2;IL24;IL20;IL22;ACVR1B;XCR1 |
| FoxO signaling pathway | PIK3R2;CCND1;FOXG1A;IGF1;PLK1;SMAD3A;CCND2;PIK3CG;NLK |
| Cell cycle | CENPJ;CENPL;FOXM1;MCM8;BUB1;MSH5;CDK5RAP2;DCTN1A;KIF2C |
| Endocytosis | CAV3;ERBB3B;SMAP1;LDLRAP1A;ARPC3;CCDC53;RAB35B;KITB;ARFGEF2 |
| TGF-beta signaling pathway | ZFYVE9;BMP6;ROCK2B;TGIF2;BMPR2A;TGIF1;BMPR2;BAMBI;ID2A |
| Hippo signaling pathway | TEAD1;AMH;ACTB;CCND2;SMAD2;APC2;PPP2CB;LEF1;PPP2R1B |
| Leishmaniasis | ITGB1;ITGB2;CYBA;HLA-DQB1;TGFB3;STAT1;HLA-DPA1;TAB2;ITGA4 |
| Chagas disease (American trypanosomiasis) | GNAS;MAPK11;ACE;RELA;PIK3CD;MAPK9;MAP2K4;FOS;MAPK1 |
| Malaria | HBB-B1;HBB-B2;KLRB1;THBS3;THBS4;TLR9;GYPC;HBA1;SELP |
| Toxoplasmosis | MAP3K7;TLR4;IRGM1;TRAF6;CD40;LAMA3;HSPA1B;Toxoplasma Gondii Microneme Protein MIC3;STAT3 |
| Amoebiasis | GM-CSF;PRKCB;SERPINB1A;TLR4;LAMB3;ACTN1;COL4A1;GNAS;CTSG |
| Tuberculosis | RAB5B;HLA-DMB;CALM3;PPP3R1;CLEC4E;BCL10;LSP1;IFNA12;H2-AB1 |
| Hepatitis B | CASP12;CCND1;ELK1;TLR3;NFKB1;HRAS;TICAM2;TLR2;SRC |
| HTLV-I infection | FZD8;PIK3R5;WNT7A;WNT1;ITGAL;MYBL1;HLA-DRA;RELA;ELK1 |
| Pathways in cancer | FH;BCL2L1;AKT1;ITGA2B;PTEN;CUL2;CYCS;AGTR1A;CASP8 |
| Colorectal cancer | PIK3R3;MAPK10;PIK3CB;TGFB1;AXIN1;APPL1;MAPK3;AXIN2;TCF7 |
| Renal cell carcinoma | RAP1B;MAPK1;PIK3CG;ARNT2;PTPN11;CUL2;ARNT;GAB1;PIK3R5 |
| Pancreatic cancer | TGFB3;PLD1;MAPK3;PIK3R5;PIK3R3;PIK3CB;TGFB2;RB1;AKT1 |
| Chronic myeloid leukemia | BRAF;GRB2;TGFB1;BCR;NFKB1;ABL1;PIK3CB;IKBKB;CTBP2 |
| Inflammatory bowel disease (IBD) | RORC;IL17A;MAF;IL22;IL13;Il23a;IL23;IL12B;IFNG |
| Rheumatoid arthritis | IL1B;TNFRSF11A;IL-8;ATP6V1H;ATP6V0E2;HLA-DPA1;ATP6V1E2;IFNG;ATP6V1A |
| Hypertrophic cardiomyopathy (HCM) | IL6;ITGA2B;MYBPC3;CACNA2D3;RYR2;ITGB5;Itga10&Itgb1;ITGB4;TGFB3 |
| Dilated cardiomyopathy | ATP2A2;CACNG7;ITGA10;TGFB1;SGCB;ITGA3;ITGA4;LAMA2;ITGB7 |
TGFB3 has several biochemical functions, for example, cytokine activity, growth factor activity, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TGFB3 itself. We selected most functions TGFB3 had, and list some proteins which have the same functions with TGFB3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cytokine activity | IL16;WNT2;TNFSF4;IFNA14;CCL20B;GPI1;THPO;IFNG;MIF |
| growth factor activity | BMP6;IL9;THBS4;INHBA;CSF1A;COL20A1;IL10;GDNF;TGFB1 |
| identical protein binding | ATXN10;PRPS2;SLC2A1;CTSC;ABCD1;MTSS1;TRIM21;SH2B2;YWHAZ |
| protein binding | FAM53C;BRK1;AREG;RAB17;MRC2;PLEKHA1;PPP1R15B;LETMD1;GRM2 |
| protein heterodimerization activity | TAF6;ITGA3;HIST1H2BB;HIST2H3C;VEGFB;BAX;PDZD7;VOX;HAND1 |
| transforming growth factor beta binding | HYAL2;ACVR1;LTBP4;ENG;TGFBR3;THBS1;VASN;ITGAV;TGFBR1 |
| type I transforming growth factor beta receptor binding | TGFB1;ENG;FKBP1A;TGFBR2;SMAD7;SNX25;TGFB3;SMAD2;SMAD6 |
| type II transforming growth factor beta receptor binding | TGFB3;TGFB1A;BAMBI;TGFBR3;TGFB1;TGFBR1;TGFB2;ENG |
| type III transforming growth factor beta receptor binding | TGFB1;TGFB3;TGFBR2;TGFB2 |
TGFB3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TGFB3 here. Most of them are supplied by our site. Hope this information will be useful for your research of TGFB3.
TGFBR2; TGFBR1; TGFBR3; CHMP2A; SDC4; CCL20
Research Area
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Customer Reviews (3)
Write a reviewReproducibility is very good, and the results are very consistent in each experiment or application, making it ideal for experiments or applications that require a high degree of reproducibility.
Their recombinant proteins are very soluble and can be easily dissolved in various buffers.
Catalytic activity of this protein is very high, which can greatly reduce the time and energy required for chemical reactions and has high economic value.
Q&As (6)
Ask a questionCurrently, researchers are exploring treatments that target TGFB3. Several drugs and antibodies have shown potential efficacy against TGFB3 and are being used in clinical trials for the treatment of the disease.
TGFB3 can regulate cell proliferation by activating multiple signaling pathways, such as the Smad signaling pathway and non-Smad signaling pathway. It can promote the progression of the cell cycle or inhibit cell proliferation, depending on the cell type and context.
TGFB3 protein can be used as a biomarker to assist the clinical diagnosis of a variety of diseases, such as congenital developmental abnormalities, inflammatory diseases and fibrotic diseases. Measuring TGFB3 protein levels can provide an indicator of early diagnosis and prognostic assessment of disease.
Mutations in TGFB3 have been found to be associated with inherited connective tissue diseases such as Loeys-Dietz syndrome and Marfan syndrome.
In pulmonary fibrosis, the expression of TGFB3 is elevated and is involved in the development of pulmonary fibrosis. Due to its important role in the pathological process, inhibition of the TGFB3 signaling pathway may be a potential strategy for the treatment of pulmonary fibrosis.
TGFB3 plays an important regulatory role in the immune system. It can influence the immune response through the proliferation, differentiation, and functional regulation of immune cells.
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