TGFB3

  • Official Full Name

    transforming growth factor, beta 3

  • Overview

    This gene encodes a member of the TGF-beta family of proteins. The encoded protein is secreted and is involved in embryogenesis and cell differentiation. Defects in this gene are a cause of familial arrhythmogenic right ventricular dysplasia 1.
  • Synonyms

    TGFB3; transforming growth factor, beta 3; ARVD; FLJ16571; TGF-beta3; transforming growth factor beta-3; TGF-beta-3; MGC105479; MGC118722; TGF beta 3; TGF beta3; TGFB 3; TGFB3_HUMAN; transforming growth factor beta 3; OTTHUMP00000246179; OTTHUMP00000246180;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Transfected Stable Cell Lines
  • GMP Proteins
  • Cattle
  • Chicken
  • Human
  • Human/Mouse
  • Mouse
  • Pig
  • Rabbit
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • CHO
  • E.coli
  • HEK293
  • HEK293T
  • Human
  • Human Cell
  • Human cells
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Nicotiana Benthamiana
  • Sf21 Insect Cell
  • Avi
  • C
  • His
  • Fc
  • Flag
  • hFc
  • His (Fc)
  • His|GST
  • His|T7
  • SUMO
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TGFB3-468H Active Recombinant Human Transforming Growth Factor, Beta 3, Dimeric Form Nicotiana Benthamiana N/A
Human TGFB3-598H Active Recombinant Human Transforming Growth Factor, Beta 3 Human N/A
Human TGFB3-128H Active Recombinant Human TGFB3, Animal Free Nicotiana Benthamiana N/A
Human TGFB3-376H Active Recombinant Human Transforming Growth Factor, Beta 3 HEK293 N/A
Human TGFB3-018H Active Recombinant Human TGFB3 Protein CHO N/A
Human TGFB3-017H Active Recombinant Human TGFB3 Protein E.coli N/A
Human TGFB3-17H Active Recombinant Human TGFB3 protein HEK293 N/A Ala 301 - Ser 412
Human TGFB3-2174H Active Recombinant Human TGFB3 protein, His & Avi-tagged, Biotinylated HEK293 His & Avi Leu 24 - Ser 412
Human TGFb3-3271H Active Recombinant Human TGFb3 protein, His-tagged E.coli His Leu24~Arg300
Human TGFB3-16H Active Recombinant Human TGFB3 protein, His-tagged HEK293 His Leu 24 - Ser 412
Human TGFB3-2165H Active Recombinant Human TGFB3 protein HEK293 N/A Ala 301 - Ser 412
Human TGFB3-12H Recombinant Human TGFB3, His-tagged E.coli His
Human TGFB3-007N Recombinant Human Transforming Growth Factor, Beta 3, Monomeric Form Nicotiana Benthamiana N/A
Human TGFB3-349H Recombinant Human Transforming Growth Factor, Beta 3 Sf21 Insect Cell N/A
Human TGFB3-126H Recombinant Human TGFB3, Animal Free Nicotiana Benthamiana N/A
Human TGFB3-65H Recombinant Human Transforming Growth Ffactor, Beta 3 E.coli N/A
Human TGFB3-006N Recombinant Human Transforming Growth Factor, Beta 3, Dimeric Form Nicotiana Benthamiana N/A
Human TGFB3-1571H Recombinant human TGFB3, Active Nicotiana Benthamiana N/A
Human TGFB3-1118HCL Recombinant Human TGFB3 293 Cell Lysate HEK293 N/A
Human TGFB3-2182H-B Recombinant Human TGFB3 Protein Pre-coupled Magnetic Beads HEK293
Human TGFB3-105H Active Recombinant Human TGFB3 Protein E.coli
Human TGFB3-2764H Recombinant Human TGFB3 Protein, His-tagged E.coli N-His Ala301-Ser412
Human TGFB3-31H Human Transforming Growth Factor-BETA 3 Reference standard N/A
Human TGFB3-125H Recombinant Human TGFB3 Protein Human Cell Ala301-Ser412(Tyr340Phe)
Human TGFB3-0260H Recombinant Human TGFB3 protein, hFc-tagged HEK293 hFc Ala301-Ser412
Human TGFB3-104HG Active GMP Recombinant Human TGFB3 Protein Insect Cell N/A
Human TGFB3-3572H Recombinant Human TGFB3 protein, His-SUMO-tagged E.coli His-SUMO 24-300aa
Human TGFB3-38H Recombinant Human TGFB3 Protein E.coli
Human TGFB3-2182H Recombinant Human TGFB3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human TGFB3-48H Active Recombinant Human TGFB3 Protein, Animal Free Human cells
Human TGFB3-600HB Recombinant Human TGFB3 protein, Avi-tagged, Biotinylated HEK293 Avi Ala 301 - Ser 412
Human TGFB3-1865HFL Recombinant Full Length Human TGFB3 Protein, C-Flag-tagged Mammalian cells Flag
Human TGFB3-193HG Active GMP Recombinant Human TGFB3 protein, Fc-tagged HEK293 Fc DNA sequence encoding Human TGF-β3(CAA33024.1) was expressed with Fc tag at the C-terminal.
Human TGFB3-288H Active Recombinant Human TGFB3 Protein (Ala301-Ser412), C-His tagged, Animal-free, Carrier-free E.coli C-His Ala301-Ser412
Human TGFB3-2462H Recombinant Human TGFB3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Mouse Tgfb3-6390M Recombinant Mouse Tgfb3 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Tgfb3-2129M Recombinant Mouse Tgfb3 Protein, His-tagged E.coli N-His Ala299-Ser410
Rat TGFB3-6038R Active Recombinant Rat Tgfb3 protein, His-tagged E.coli His Ala301~Ser412
Rabbit TGFB3-1254R Recombinant Rabbit TGFB3 Protein, His-tagged E.coli N-His Ala192-Ser303
Cattle TGFB3-2003C Recombinant Cattle TGFB3 protein, His & GST-tagged E.coli His/GST Glu314~Ala412 (Accession # A6QP91)
Human/Mouse TGFB3-245H Active Recombinant Human/Mouse TGFB3 Protein E.coli
Human/Mouse TGFB3-246H Active Recombinant Human/Mouse TGFB3 Protein E.coli
Human/Mouse TGFB3-247H Active Recombinant Human/Mouse TGFB3 Protein E.coli
Human/Mouse TGFB3-248H Active Recombinant Human/Mouse TGFB3 Protein E.coli
Rhesus Macaque TGFB3-4688R Recombinant Rhesus monkey TGFB3 Protein, His-tagged Mammalian Cell His
Rhesus Macaque TGFB3-4502R Recombinant Rhesus Macaque TGFB3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque TGFB3-4502R-B Recombinant Rhesus Macaque TGFB3 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish TGFB3-9736Z Recombinant Zebrafish TGFB3 Mammalian Cell His
Pig TGFB3-2004P Recombinant Pig TGFB3 protein, His & T7-tagged E.coli His/T7 Ala298~Ser409 (Accession # P15203)
Chicken TGFB3-7004C Recombinant Chicken TGFB3 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource
  • TGFB3 Related Signal Pathway

TGFB3 involved in several pathways and played different roles in them. We selected most pathways TGFB3 participated on our site, such as MAPK signaling pathway, Cytokine-cytokine receptor interaction, FoxO signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TGFB3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayPPP5C;NR4A1;RASA2;CASP3A;KRAS;FGF12;PPM1NB;CACNB4A;GNA12A
Cytokine-cytokine receptor interactionIL19;TGFBR1A;IL1R1;IL21R.1;EPOR;IL23R;CCL16;TNFSF18;TNFRSF18
FoxO signaling pathwayHOMER1B;S1PR1;PRKAG2A;PIK3CD;MAPK3;CAT;PCK2;NLK;RAF1
Cell cycleCENPH;ORC5;SKP2;CLIP1;CDC14B;ESCO1;ORC1L;MAPRE1;MDM2
EndocytosisRAB11B;VPS36;AGAP1;EPN2;WASL;PIP5K1B;KITA;ADRB2A;HLA-B
TGF-beta signaling pathwayIFNG1-2;BMPR1AB;ACVR2A;BMP4;TFDP1;NODAL;TGFBR2;TGFB1A;CHRD
Hippo signaling pathwayYAP1;CTGF;FZD9;PPP1CC;WNT5B;YWHAB;YWHAE;WWTR1;FZD3
LeishmaniasisTRAF6;HLA-DRB1;ITGB2L;C3;IL4;ITGA4;FCGR2A;IFNG;PRKCB
Chagas disease (American trypanosomiasis)MAPK10;FOS;TGFB2;FADD;NOS2;IL1B;BDKRB2;GNAO1;CD247
MalariaHBA2;ICAM1;TGFB2;HBA1;LRP1;ITGB2;IL12A;CD40;GYPC
ToxoplasmosisCYCS;ITGA6;LAMA4;NOS2;Toxoplasma Gondii Profilin Family Protein;LY96;HLA-DQA2;IL12B;HLA-DRA
AmoebiasisPRKACB;LAMB2;Itgam&Itgb2;RELA;PIK3CA;SERPINB3C;COL4A1;COL4A6;CD14
TuberculosisCALM3;ATP6V0A1;cgr2b;FCGR2A;RELA;CALML3;IL12A;CASP10;MYD88
Hepatitis BMAPK3;ATF4;IFN-a;CREB3L2;TGFBR1;MAP2K1;MAPK10;MAVS;TGFB2
HTLV-I infectionANAPC5;ANAPC11;ANAPC7;HLA-DOA;WNT9A;WNT2;PIK3R3;CALR;SLC2A1
Pathways in cancerHSP90AA1;CBL;GNA12;BIRC5;Fgf15;HIF1A;NOS2;TCF7L2;PIK3CG
Colorectal cancerMAPK10;CCND1;AKT1;PIK3CD;BAX;MLH1;MSH3;LEF1;BAD
Renal cell carcinomaCDC42;PAK3;PDGFB;EGLN2;PIK3CA;KRAS;MAPK3;VHL;TGFB2
Pancreatic cancerRALGDS;STAT3;KRAS;CASP9;TGFBR1;AKT2;PIK3CA;TGFB2;CCND1
Chronic myeloid leukemiaMAP2K2;GAB2;SMAD4;TGFB2;HDAC2;KRAS;SOS1;IKBKG;TGFB1
Inflammatory bowel disease (IBD)IL5;HLA-DRB5;IL18RAP;Il23a;HLA-DRB3;IL12RB2;TBX21;IL17F;H2-AA
Rheumatoid arthritisCcl12;HLA-DRB4;TLR2;ATP6V0E1;H2-AB1;ATP6V1D;CD80;Ctsl;ACP5
Hypertrophic cardiomyopathy (HCM)MYL3;ITGB3;MYH7;TNNC1;SLC8A1;ACTG1;CACNG3;ITGB8;TPM4
Dilated cardiomyopathyCACNB4;ITGB8;LAMA2;TNNC1;TNF;CACNA2D3;ITGA9;ITGB4;ITGB3

TGFB3 has several biochemical functions, for example, cytokine activity, growth factor activity, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TGFB3 itself. We selected most functions TGFB3 had, and list some proteins which have the same functions with TGFB3. You can find most of the proteins on our site.

Function Related Protein
cytokine activityBMP7A;TNFSF4;TXLNA;IL24;IFNA6;TNFSF18;IL17F;GDF10B;IFNA4
growth factor activityFGF13B;FGF10A;FGF1A;AGT;NGF;PROK1;FGF8B;BMP2;BDNF
identical protein bindingNME1;ATL1;RAD52;MYOM1;RUNX1T1;DAPK2;PHC2;TNK2;KCTD13
protein bindingTTC5;TTLL10;C1QTNF8;CXXC11;OBSCN;PSMD6;CD86;FKBP4;FANCG
protein heterodimerization activityHYPM;HIST1H2AK;H2AFVA;BCL2;SNX2;H2BFWT;AGTR1A;TGFB2;IKBKG
transforming growth factor beta bindingLTBP4;THBS1;LTBP1;HYAL2;TGFBR1;TGFBR2;ITGAV;CD109;TGFB3
type I transforming growth factor beta receptor bindingSMAD2;SMAD7;TGFB1;TGFB3;FKBP1A;ENG;SMAD6;TGFBR2;SNX25
type II transforming growth factor beta receptor bindingTGFB3;ENG;TGFB1;TGFB1A;TGFBR1;TGFB2;TGFBR3;BAMBI
type III transforming growth factor beta receptor bindingTGFB3;TGFB2;TGFBR2;TGFB1

TGFB3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TGFB3 here. Most of them are supplied by our site. Hope this information will be useful for your research of TGFB3.

TGFBR2; TGFBR1; TGFBR3; CHMP2A; SDC4; CCL20

Research Area

Related articles

Petra, H; Eva, H; et al. Molecular Profiling of Acute and Chronic Rejections of Renal Allografts. CLINICAL & DEVELOPMENTAL IMMUNOLOGY :-(2013).
Le, M; Naridze, R; et al. Transforming Growth Factor Beta 3 Is Required for Excisional Wound Repair In Vivo. PLOS ONE 7:-(2012).
  • Q&As
  • Reviews

Q&As (6)

Ask a question
Is there a treatment for TGFB3? 12/16/2019

Currently, researchers are exploring treatments that target TGFB3. Several drugs and antibodies have shown potential efficacy against TGFB3 and are being used in clinical trials for the treatment of the disease.

How does TGFB3 participate in cell proliferation? 08/27/2019

TGFB3 can regulate cell proliferation by activating multiple signaling pathways, such as the Smad signaling pathway and non-Smad signaling pathway. It can promote the progression of the cell cycle or inhibit cell proliferation, depending on the cell type and context.

What are the applications of TGFB3 protein in clinical diagnosis? 07/25/2019

TGFB3 protein can be used as a biomarker to assist the clinical diagnosis of a variety of diseases, such as congenital developmental abnormalities, inflammatory diseases and fibrotic diseases. Measuring TGFB3 protein levels can provide an indicator of early diagnosis and prognostic assessment of disease.

Are there any genetic diseases associated with TGFB3? 06/23/2019

Mutations in TGFB3 have been found to be associated with inherited connective tissue diseases such as Loeys-Dietz syndrome and Marfan syndrome.

Is TGFB3 potentially used to treat pulmonary fibrosis? 05/25/2019

In pulmonary fibrosis, the expression of TGFB3 is elevated and is involved in the development of pulmonary fibrosis. Due to its important role in the pathological process, inhibition of the TGFB3 signaling pathway may be a potential strategy for the treatment of pulmonary fibrosis.

How is TGFB3 related to the immune system? 04/13/2019

TGFB3 plays an important regulatory role in the immune system. It can influence the immune response through the proliferation, differentiation, and functional regulation of immune cells.

Customer Reviews (3)

Write a review
Reviews
12/08/2019

    Reproducibility is very good, and the results are very consistent in each experiment or application, making it ideal for experiments or applications that require a high degree of reproducibility.

    10/13/2019

      Their recombinant proteins are very soluble and can be easily dissolved in various buffers.

      05/19/2019

        Catalytic activity of this protein is very high, which can greatly reduce the time and energy required for chemical reactions and has high economic value.

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