tgfb1
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  • Official Full Name
  • Transforming Growth Factor, Beta 1
  • Background
  • Transforming growth factor beta 1 or TGF-β1 is a polypeptide member of the transforming growth factor beta superfamily of cytokines. It is a secreted protein that performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation and apoptosis. In humans, TGF-β1 is encoded by the TGFB1 gene.
  • Synonyms
  • Tgfb1; transforming growth factor, beta 1; CED; LAP; DPD1; TGFB; TGFbeta; TGF-beta 1 protein; latency-associated peptide; Camurati-Engelmann disease; Transforming growth factor beta-1; TGF-beta-1; Camui Engelmann disease; Diaphyseal dysplasia 1 progressive; TGF beta 1; TGF beta; TGF beta 1 protein; TGF-beta-5; TGF-beta1; Tgfb-1; TGFB1_HUMAN; TGFbeta1; Transforming Growth Factor b1; Transforming Growth Factor beta 1; Transforming growth factor beta 1a
Cat.#:TGFB1-706HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human TGFB1 Protein, MYC/DDK-tagged
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Cat.#:Tgfb1-1384RTag:His-SUMO
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Tgfb1 Protein, His-SUMO-tagged
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Cat.#:TGFB1-1385CTag:His
Source (Host):E. coliSpecies:Cattle
Product nameRecombinant Cattle TGFB1 Protein, His-tagged
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Cat.#:TGFB1-119HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Transforming Growth Factor, Beta 1, GST-tagged
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Cat.#:TGFB1-014HTag:
Source (Host):CHO cellSpecies:Human
Product nameRecombinant Human TGFB1 Protein
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Cat.#:TGFB1-057HTag:
Source (Host):HEK293 cellsSpecies:Human
Product nameRecombinant Human TGFB1 Protein
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Cat.#:TGFB1-120HTag:N/A
Source (Host):CHOSpecies:Human
Product nameRecombinant Human TGFB1
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Cat.#:TGFB1-196HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TGFB1
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Cat.#:TGFB1-219HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human TGFB1, MIgG2a Fc-tagged
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Cat.#:TGFB1-220HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human TGFB1, HIgG4 Fc-tagged
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Cat.#:TGFB1-244HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TGFB1 protein, His-tagged
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Cat.#:TGFB1-3209HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TGFB1, His-tagged
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Cat.#:TGFB1-336HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human TGFB1 protein, His-tagged
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Cat.#:TGFB1-345HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TGFB1 protein, His/MBP-tagged
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Cat.#:TGFB1-427HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human TGFB1, Fc tagged
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Cat.#:TGFB1-428HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human TGFB1
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Cat.#:TGFB1-429HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TGFB1 Protein, His-tagged
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Cat.#:TGFB1-4322HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human TGFB1 protein, GST-tagged
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Cat.#:TGFB1-489HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human TGFB1, His tagged
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Cat.#:TGFB1-509HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human TGFB1, Fc-tagged
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Cat.#:TGFB1-518HTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human TGFB1
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Cat.#:Tgfb1-242MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Tgfb1 protein, His-tagged
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Cat.#:Tgfb1-520MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Tgfb1, His-tagged
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Cat.#:TGFB1-576MTag:N/A
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Tgfb1
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Cat.#:TGFB1-152RTag:His
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Tgfb1, His tagged
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Cat.#:TGFB1-153RTag:
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat TGFB1 protein
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Cat.#:Tgfb1-26RTag:His
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Tgfb1 Protein, His-tagged
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Cat.#:Tgfb1-531RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Tgfb1 protein, His-tagged
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Cat.#:TGFB1-6035RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat TGFB1 Protein
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Cat.#:TGFB1-1215CTag:His
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus TGFB1 Protein, His-tagged
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Cat.#:TGFB1-1051CTag:His
Source (Host):HEK293Species:Canine
Product nameRecombinant Canine TGFB1 Protein, His-tagged
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Cat.#:TGFB1-525DTag:His/GST
Source (Host):E. coliSpecies:Dog
Product nameRecombinant Dog TGFB1 protein, His & GST-tagged
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Cat.#:TGFB1-526CTag:His
Source (Host):E. coliSpecies:Chicken
Product nameRecombinant Chicken TGFB1 protein, His-tagged
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Cat.#:TGFB1-532RTag:His/T7
Source (Host):E. coliSpecies:Rabbit
Product nameRecombinant Rabbit TGFB1 protein, His & T7-tagged
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Cat.#:TGFB1-524CTag:His/GST
Source (Host):E. coliSpecies:Cattle
Product nameRecombinant Cattle TGFB1 protein, His & GST-tagged
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Cat.#:Tgfb1-527GTag:His/S
Source (Host):E. coliSpecies:Guinea pig
Product nameRecombinant Guinea pig Tgfb1 protein, His & S-tagged
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Cat.#:TGFB1-529STag:His/GST
Source (Host):E. coliSpecies:Sheep
Product nameRecombinant Sheep TGFB1 protein, His & GST-tagged
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Cat.#:TGFB1-530PTag:His
Source (Host):E. coliSpecies:Pig
Product nameRecombinant Pig TGFB1 protein, His-tagged
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Cat.#:TGFB1-539HTag:N/A
Source (Host):CHOSpecies:Human
Product nameRecombinant Human TGFB1
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Cat.#:TGFB1-594HTag:N/A
Source (Host):Human PlateletsSpecies:Human
Product nameRecombinant Human Transforming Growth Factor, Beta 1
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Cat.#:TGFB1-126HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Transforming Growth Factor, beta 1
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Cat.#:TGFB1-908HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Transforming Growth Factor, Beta 1, His-tagged
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Cat.#:TGFB1-21HTag:N/A
Source (Host):Species:Human
Product nameNative Human TGF- β1
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Cat.#:TGFB1-001HCLTag:
Source (Host):CHOSpecies:Human
Product nameRecombinant Human TGFB1 cell lysate
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Cat.#:TGFB1-2662HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human TGFB1 cell lysate
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Cat.#:TGFB1-001MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse TGFB1 cell lysate
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Cat.#:TGFB1-803RCLTag:
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat TGFB1 cell lysate
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Cat.#:TGFB1-134HGTag:
Source (Host):CHO cellSpecies:Human
Product nameGMP Recombinant Human TGFB1 Protein
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Cat.#:TGFB1-159HGTag:
Source (Host):HEK293 cellSpecies:Human
Product nameGMP Recombinant Human TGFB1 Protein
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Cat.#:TGFB1-95HTag:
Source (Host):Species:Human
Product nameHuman Transforming Growth Factor beta-1 (rDNA derived) Reference standard
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Cat.#:TGFB1-96BTag:
Source (Host):Species:Bovine
Product nameBovine Transforming Growth Factor beta-1 Reference standard
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Cat.#:CSC-P0323Tag:
Source (Host):Species:
Product nameAnti-Human TGF-beta MAb Stable Cell Line-CHO
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Cat.#:CSC-P0324Tag:
Source (Host):Species:
Product nameAnti-Human TGF-beta F(ab) Stable Cell Line-CHO
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Cat.#:CSC-P0325Tag:
Source (Host):Species:
Product nameAnti-Human TGF-beta scFv Stable Cell Line-CHO
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Involved Pathway

Tgfb1 involved in several pathways and played different roles in them. We selected most pathways Tgfb1 participated on our site, such as MAPK signaling pathway, Cytokine-cytokine receptor interaction, FoxO signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Tgfb1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
FLNB; RAC3; TGFBR1B; CACNB1; CACNA1B; PDGFB; CASP3B; HSPA1B; MAP3K1; AKT3A
Cytokine-cytokine receptor interaction
IL8L1; IL25; IL8L2; CCL7; IFNE; CCL15; CCL21; CXCR5; EDA; PRL2
FoxO signaling pathway
FASLG; SIRT1; BNIP4; BRAF; IRS4; KLF2A; GADD45AA; FOXO1; FOXO6; HOMER2
Cell cycle
CDC26; CENPL; TFDP1; ABL1; NCAPH; LMNB1; YWHAH; RNF168; NUP50; OFD1
Endocytosis
RNF41; ARF3B; SMAP1; HSPA2; ARPC1B; FGFR3; RAB11FIP5; MET; ADRB2B; ARF6A
TGF-beta signaling pathway
SMURF1; RPS6KB2; BMP7B; NDR1; MAPK3; AMH; TGFBR1A; BMP8A; TGIF2; INHBC
Osteoclast differentiation
NCF1; GRB2; TGFB1; NOX3; PIK3R2; TNFRSF11B; IFNG; PPP3CA; BLNK; MAPK12
Hippo signaling pathway
NF2; Fzd4; FGF1; GDF5; WNT5B; SMAD1; AXIN2; RASSF1; PPP2R2A; SMAD4
Intestinal i
IL4; LTBR; HLA-DPA1; IL6; MHC2DAB; MAP3K14; HLA-DRA; HLA-DPB1; BMA2; HLA-DOA
ne network for IgA production
CCL28; CD40LG; CD40; TGFB1A; HLA-DOA; CD80; IL4; IL15; CXCL12A; ICOS
Non-alcoholic fatty liver disease (NAFLD)
AKT2; NDUFB11; NR1H3; NDUFV2; PRKAG3; IKBKB; MAPK10; COX7B; NDUFB4; ADIPOQ
Leishmaniasis
CYBA; HLA-DMB; HLA-DRB5; ITGB2; IFNG; HLA-DPA1; IL1A; HLA-DOA; ELK1; MYD88
Chagas disease (American trypanosomiasis)
C3; IFNGR2; TLR9; TGFB2; CCL5; GNAS; CCL2; IKBKB; TLR4; PIK3R2
Malaria
DARC; THBS4; TLR2; CSF3; ITGB2L; KLRC4-KLRK1; IL18; SDC2; TGFB1; GYPB
Toxoplasmosis
HLA-DRB3; HLA-DQB1; HSPA1L; RELA; PIK3R1; MAPK1; BIRC8; BIRC3; LAMB1; MYD88
Amoebiasis
GNAS; LAMC1; ITGB2L; LAMA3; IL-8; PRKACG; ACTN2; LAMA4; FN1; LAMB3
Tuberculosis
cgr2b; RHOA; EEA1; ITGB2; HLA-DMA; HLA-DMB; KSR1; FCGR3B; IFNG; CAMK2G
Hepatitis B
TP53; EP300; CCNE1; IFNA21; NFATC1; IFNA10; MAP2K2; CASP12; GRB2; MAPK1
HTLV-I infection
FOS; POLE2; NRAS; HRAS; PPP3CC; CRTC1; FZD7; CDC16; ANAPC5; FZD3
Pathways in cancer
DAPK3; RET; MAPK1; RXRA; STAT5A; FGF14; EPAS1; BRCA2; FGF9; FZD5
Proteoglycans in cancer
PTCH1; DDX5; ITGAV; TLR4; VTN; RDX; RAF1; FZD8; ELK1; PDCD4
Colorectal cancer
KRAS; FOS; Casp3; MAPK1; CYCS; LEF1; TGFB3; TRP53; BRAF; BIRC5
Renal cell carcinoma
ETS1; PIK3R2; MET; KRAS; PIK3CB; CDC42; RAC1; ARAF; AHA-1; TCEB2
Pancreatic cancer
RALBP1; ARHGEF6; PIK3CA; NFKB1; AKT1; TGFA; IKBKB; MAPK3; PIK3R5; RALGDS
Chronic myeloid leukemia
RUNX1; PIK3R5; IKBKG; MAPK1; RB1; CRK; ARAF; GRB2; TGFB3; STAT5B
Inflammatory bowel disease (IBD)
STAT6; NFKB1; STAT1; IL23; IL1B; TLR5; IL18RAP; IL12B; HLA-DQB1; NFATC1
Rheumatoid arthritis
CD28; ATP6V1C1; CD80; HLA-DPA1; ACP5; CD86; TLR2; ATP6V1E1; HLA-DMB; ATP6V0E1
Hypertrophic cardiomyopathy (HCM)
ITGB1; ITGA4; PRKAG2; SGCB; CACNB2; SGCD; TNNI3; ITGAV; ITGA9; MYH7
Dilated cardiomyopathy
ACTB; ITGA9; ADRB1; ITGA2B; ITGAV; PRKACA; SGCG; CACNA2D1; ITGB6; ITGB8

Protein Function

Tgfb1 has several biochemical functions, for example, antigen binding, cytokine activity, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Tgfb1 itself. We selected most functions Tgfb1 had, and list some proteins which have the same functions with Tgfb1. You can find most of the proteins on our site.
Function
Related Protein
Function antigen binding
Related Protein SLAMF1; FCN2; IGLL1; LCK; TGFB1; IgG3; SPON2; Ighg2a; TSPAN4; KIR2DL3
Function cytokine activity
Related Protein IFNA12; BMP3; TNFSF8; GDF10; CLCF1; IFNG1-2; LEFTY2; GDF6B; RNF207B; IFNK
Function enzyme binding
Related Protein CNTNAP2; GSTM1; Ar; HIST1H2AD; NR5A1; USP22; BCHE; UBE2L3; TMBIM6; UGT1A6A
Function glycoprotein binding
Related Protein APOH; FYN; ITGAM; CALR; PIP; EDEM1; AZGP1; LCK; CD4; CANX
Function growth factor activity
Related Protein NRTN; NDP; BMP6; RABEP1; IL5; PTN; FGF13B; NENF; FGF8; PDGFA
Function protein N-terminus binding
Related Protein SERPINB1A; PDCD10; NIPBL; MAP2K1; SUV39H1; SDCBP; THAP7; LACRT; VPS25; TBL1XR1
Function protein binding
Related Protein DGCR8; NUP133; UNC13A; SH2D2A; SPSB1; MRAP; MAP1LC3C; HELT; PCNP; SLC25A46
Function protein heterodimerization activity
Related Protein HIST1H3D; TCF12; H2AFVB; CEBPA; PKNOX1; SEPHS1; H2AFJ; F11R.1; EGFR; HIST1H4C
Function protein homodimerization activity
Related Protein SRM; AGR2; TCF3B; GDNFA; TREX1; HINT2; LMLN; E2F8; FGFR1OP2; FGFR1OP
Function type I transforming growth factor beta receptor binding
Related Protein TGFB1; TGFB3; SMAD6; SMAD7; TGFBR2; FKBP1A; SMAD2; ENG; SNX25
Function type II transforming growth factor beta receptor binding
Related Protein TGFBR3; TGFB1A; ENG; TGFB3; TGFB1; TGFB2; BAMBI; TGFBR1
Function type III transforming growth factor beta receptor binding
Related Protein TGFB3; TGFB1; TGFB2; TGFBR2

Interacting Protein

Tgfb1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Tgfb1 here. Most of them are supplied by our site. Hope this information will be useful for your research of Tgfb1.
TGFBR2; APP; MEOX2; 80125; FSTL1; THBS1; ENG

Tgfb1 Related Articles

Mrizak, D; Martin, N; et al. Effect of Nasopharyngeal Carcinoma-Derived Exosomes on Human Regulatory T Cells. JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE 107:-(2015).
Wang, YD; Rajanbabu, V; et al. Transcriptome analysis of medaka following epinecidin-1 and TH1-5 treatment of NNV infection. FISH & SHELLFISH IMMUNOLOGY 42:121-131(2015).

Tgfb1 Related Gene Family

TGF