Tgfb1

  • Official Full Name

    Transforming Growth Factor, Beta 1

  • Overview

    Transforming growth factor beta 1 or TGF-β1 is a polypeptide member of the transforming growth factor beta superfamily of cytokines. It is a secreted protein that performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation and apoptosis. In humans, TGF-β1 is encoded by the TGFB1 gene.
  • Synonyms

    Tgfb1; transforming growth factor, beta 1; CED; LAP; DPD1; TGFB; TGFbeta; TGF-beta 1 protein; latency-associated peptide; Camurati-Engelmann disease; Transforming growth factor beta-1; TGF-beta-1; Camui Engelmann disease; Diaphyseal dysplasia 1 progressive; TGF beta 1; TGF beta; TGF beta 1 protein; TGF-beta-5; TGF-beta1; Tgfb-1; TGFB1_HUMAN; TGFbeta1; Transforming Growth Factor b1; Transforming Growth Factor beta 1; Transforming growth factor beta 1a;

  • Recombinant Proteins
  • Native Proteins
  • GMP Proteins
  • Cell & Tissue Lysates
  • Transfected Stable Cell Lines
  • Protein Pre-coupled Magnetic Beads
  • African clawed frog
  • Bovine
  • Canine
  • Cattle
  • Chicken
  • Cynomolgus
  • Cynomolgus Monkey
  • Dog
  • Guinea pig
  • Horse
  • Human
  • Mouse
  • Mouse / Rat
  • Mouse, Rat
  • Mouse/Rat
  • Pig
  • Porcine
  • Rabbit
  • Rat
  • Rhesus macaque
  • Salmo gairdneri
  • Sheep
  • CHO
  • CHO cells
  • CHO-K1
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • Human
  • Human Cell
  • Human cells
  • Human Platelet
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Yeast
  • Avi
  • C
  • His
  • Fc
  • FC
  • Flag
  • GST
  • His (Fc)
  • His(C
  • ter)
  • His|Avi
  • His|GST
  • His|MBP
  • His|S
  • His|SUMO
  • His|T7
  • SUMO
  • Human Fc
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
  • GFP
  • MBP
  • No tag
  • Tag Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TGFB1-120H Active Recombinant Human TGFB1 CHO N/A
Human TGFB1-539H Active Recombinant Human TGFB1 Human N/A
Human TGFB1-219H Active Recombinant Human TGFB1, MIgG2a Fc-tagged CHO Fc
Human TGFB1-428H Active Recombinant Human TGFB1 HEK293 N/A
Human TGFB1-594H Active Recombinant Human Transforming Growth Factor, Beta 1 Human N/A
Human TGFB1-21H Active Native Human TGF- β1 Human Platelet N/A
Human TGFB1-3847H Recombinant Human TGFB1 Protein(Leu30-Ser390 (C33S)), His-tagged HEK293 N-His Leu30-Ser390 (C33S)
Human TGFB1-02H Active Recombinant Human TGFB1 Protein, Fc-tagged Human cells FC 600
Human TGFB1-3755H Recombinant Human TGFB1 Protein(Leu30-Arg278(C33S)), His-Avi-tagged, Biotinylated HEK293 N-His-Avi Leu30-Arg278(C33S)
Human TGFB1-153H Active Recombinant Human TGFB1 Protein CHO N/A Ala 279-Ser 390
Human TGFB1-4129H Recombinant Human TGFB1 Protein(Leu30-Ser390 (C33S)), His-Avi-tagged, Biotinylated HEK293 N-His-Avi Leu30-Ser390 (C33S)
Human TGFB1-2198H Active Recombinant Human TGFB1 protein HEK293 N/A Leu 30 - Arg 278
Human TGFB1-01HG Active GMP Recombinant Human TGFB1 Protein CHO-K1
Human TGFB1-3753H Recombinant Human TGFB1 Protein(Leu30-Arg278(C33S)), His-tagged HEK293 N-His Leu30-Arg278(C33S)
Human TGFB1-3754H Recombinant Mature Human TGFB1 Protein(Ala279-Ser390), His-tagged HEK293 N/A Ala279-Ser390
Human TGFB1-509H Recombinant Human TGFB1 protein, Fc-tagged HEK293 Human Fc 594
Human TGFB1-336H Recombinant Human TGFB1 protein, His-tagged HEK293 His 249
Human TGFB1-244H Recombinant Human TGFB1 protein, His-tagged E.coli His
Human TGFB1-057H Active Recombinant Human TGFB1 protein HEK293 N/A Ala 279 - Ser 390
Human TGFB1-489H Active Recombinant Human TGFB1 protein, His-tagged HEK293 His Met 1-Ser 390
Human TGFB1-126H Recombinant Human Transforming Growth Factor, beta 1 E.coli N/A
Human TGFB1-014H Active Recombinant Human TGFB1 Protein CHO N/A
Human TGFB1-119H Recombinant Human Transforming Growth Factor, Beta 1, GST-tagged E.coli GST
Human TGFB1-196H Recombinant Human TGFB1 E.coli N/A
Human TGFB1-345H Recombinant Human TGFB1 protein, His/MBP-tagged E.coli His/MBP 22-195 aa
Human TGFB1-908H Recombinant Human Transforming Growth Factor, Beta 1, His-tagged E.coli His
Human TGFB1-4322H Recombinant Human TGFB1 protein, GST-tagged Wheat Germ GST
Human TGFB1-518H Recombinant Human TGFB1 protein HEK293 112
Human TGFB1-3209H Recombinant Human TGFB1, His-tagged E.coli His 13-253AA
Human TGFB1-429H Recombinant Human TGFB1 Protein, His-tagged E.coli His
Human TGFB1-001HCL Recombinant Human TGFB1 cell lysate CHO N/A
Human TGFB1-2662HCL Recombinant Human TGFB1 cell lysate Human Cell N/A
Human TGFB1-134HG Active GMP Recombinant Human TGFB1 Protein CHO N/A
Human TGFB1-363H Active Recombinant Human TGFB1 Protein, His & Avi-tagged, Biotinylated HEK293 His/Avi Leu 30 - Ser 390
Human TGFB1-2180H Recombinant Human TGFB1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human TGFB1-706H Recombinant Human TGFB1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human TGFB1-95H Human Transforming Growth Factor beta-1 (rDNA derived) Reference standard N/A
Human TGF-137H Recombinant Human TGF protein HEK293 N/A Ala279-Ser390
Human TGFB1-560H Recombinant Human TGFB1 Protein HEK293 390
Human TGFB1-335H Recombinant Human TGFB1 protein (Met1-Arg278), His-tagged HEK293 His
Human TGFB1-364H Recombinant Human TGFB1 protein, Avi-tagged HEK293 Avi Ala279-Ser390
Human TGFB1-17H Active Recombinant Human TGFB1 Protein, Pre-aliquoted CHO Ala279-Ser390
Human TGFB1-0344H Active Recombinant Human TGFB1 protein, His-Avi-tagged, Biotinylated HEK293 His-Avi Leu30-Arg278
Human TGFB1-103H Active Recombinant Human TGFB1 Protein E.coli
Human TGFB1-137HB Recombinant Mature Human TGFB1 Protein(Ala279-Ser390), Avi-tagged, Biotinylated HEK293 C-Avi Ala279-Ser390
Human TGFB1-0343H Active Recombinant Human TGFB1 protein, Fc-Avi-tagged, Biotinylated HEK293 Fc-Avi Leu30-Arg278
Human TGFB1-137H Recombinant Human TGFB1 protein, His & Avi-tagged HEK293 His & Avi Leu30-Ser390
Human TGFB1-159HG Active GMP Recombinant Human TGFB1 Protein HEK293 N/A
Human TGFB1-329HG Active GMP Recombinant Human TGFB1 protein, Fc-tagged HEK293 Fc DNA sequence encoding Human TGF-β1(NP_000651.3) was expressed with Fc tag at the C-terminal.
Human TGFB1-286H Active Recombinant Human TGFB1 Protein (Ala279-Ser390), C-His tagged, Animal-free, Carrier-free E.coli C-His Ala279-Ser390
Human TGFB1-519H Recombinant Human TGFB1(Leu30-Arg278(Cys33Ser)) Protein, None-tagged HEK293 N/A
Human TGFB1-157H Active Recombinant Human TGFB1 Protein CHO
Human TGFB1-6470H Recombinant Human TGFB1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human TGFB1-6431H Recombinant Human TGFB1 Protein (Leu30-Ser390), N-His tagged E.coli N-His Leu30-Ser390
Human TGFB1-138H Recombinant Human TGFB1(Ala279-Ser390) Protein, N-Avi-tagged, Biotinylated HEK293 Avi
Human TGFB1-73H Recombinant Human TGFB1 Protein (AA 30-390), N-His-Tagged HEK293 N-His AA 30-390
Human TGFB1-1249H Recombinant Human TGFB1 Protein, His-tagged CHO N-His Ala279-Ser390
Human TGFB1-37H Recombinant Human/Bovine/Porcine TGFB1 Protein E.coli
Human TGFB1-362H Recombinant Human TGFB1 protein, His-tagged, Biotinylated HEK293 His 370
Human TGFB1-72H Recombinant Human TGFB1 Protein (AA 30-390), N-GFP/His-Tagged HEK293 N-GFP/His AA 30-390
Human TGFB1-299H Recombinant Active Human TGFB1 Protein, His-tagged(C-ter) E.coli His(C-ter)
Human TGFB1-146HFL Active Recombinant Full Length Human TGFB1 Protein, C-Flag-tagged Mammalian cells Flag
Human TGFB1-158H Recombinant Human TGFB1 Protein, Leu30-Arg278, C33S, N-His-Avi tagged, Biotinylated HEK293 N-His-Avi Leu30-Arg278, C33S
Human TGFB1-02HG Active Recombinant Human TGFB1 Protein (Ala279-Ser390), GMP Grade CHO Ala279-Ser390
Human TGFB1-46H Active Recombinant Human TGFB1 Protein, Animal Free Human cells
Human TGFB1-04H Recombinant Human TGFB1 Protein, Fc-tagged HEK293 Fc
Human TGFB1-2510H Recombinant Human TGFB1 protein(281-390 aa), N-MBP & C-His-tagged HEK293 N-MBP & C-His 281-390 aa
Human TGFB1-1283H Recombinant Human TGFB1 Protein (M1-S390), His tagged E.coli His M1-S390
Human TGFB-13H Recombinant Human TGFB1 Protein, Fc-tagged HEK293 Fc
Human TGFB1-1250H Recombinant Human TGFB1 Protein, His-tagged E.coli N-His Leu30-Ser390
Human TGFB1-528H Recombinant Human TGFB1 Protein 390
Human TGFB1-1284H Recombinant Human TGFB1 Protein (M1-S390), Tag Free E.coli No tag M1-S390
Human TGFB1-2180H-B Recombinant Human TGFB1 Protein Pre-coupled Magnetic Beads HEK293
Human TGFB1-563H Recombinant Human TGFB1 Protein HEK293 390
Human TGFB1-6430H Recombinant Human TGFB1 Protein (Leu30-Ser390), N-His tagged Mammalian cells N-His Leu30-Ser390
Human TGFB1-666HF Recombinant Full Length Human TGFB1 Protein, GST-tagged In Vitro Cell Free System GST 390 amino acids
Human TGFB1-001H Recombinant Human TGFB1 Protein, Mature chain, Tag Free, Biotinylated HEK293 Tag Free Mature chain
Human TGFB1-2682H Active Recombinant Human TGFB1 protein, His-tagged HEK293 His Leu30-Ser390(C33S)
Human TGFB1-03H Recombinant human/bovine/porcine TGFB1 Protein, Animal-Free E. coli
Human TGFB1-6427H Recombinant Human TGFB1 Protein (Gly316-Ser390), C-His tagged Yeast C-His Gly316-Ser390
Human TGFB1-6428H Recombinant Human TGFB1 Protein (Tyr317-Ser390), N-His tagged Yeast N-His Tyr317-Ser390
Human TGFB1-6429H Recombinant Human TGFB1 Protein (Gly316-Ser390), N-His tagged Yeast N-His Gly316-Ser390
Mouse Tgfb1-01M Active GMP Recombinant Mouse Tgfb1 Protein, His-Tagged E.coli His
Mouse TGFB1-6543M Recombinant Mouse TGFB1 Protein(Leu30-Ser390), His-tagged HEK293 N-His Leu30-Ser390
Mouse Tgfb1-520M Recombinant Mouse Tgfb1 protein, His-tagged HEK293 His Met1-Ser390
Mouse Tgfb1-242M Recombinant Mouse Tgfb1 protein, His-tagged E.coli His
Mouse TGFB1-001MCL Recombinant Mouse TGFB1 cell lysate Human Cell N/A
Mouse Tgfb1-83M Active Recombinant Mouse Tgfb1 Protein (Alag279-Ser390), C-His tagged, Animal-free, Carrier-free E.coli C-His Alag279-Ser390
Mouse Tgfb1-300M Recombinant Active Mouse TGFB1 Protein, His-tagged(C-ter) E.coli His(C-ter)
Mouse TGFB1-226H Recombinant Human TGFB1 Protein Human Cell
Mouse Tgfb1-045M Recombinant Mouse Tgfb1 Protein, His-tagged HEK293 His Leu30-Ser390
Mouse Tgfb1-1251M Recombinant Mouse Tgfb1 Protein, His-tagged CHO N-His Ala279-Ser390
Mouse Tgfb1-6387M Recombinant Mouse Tgfb1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Tgfb1-7348M Recombinant Mouse Tgfb1 Protein, His-tagged E.coli His 279-390
Mouse Tgfb1-520MB Recombinant Mouse Tgfb1 protein, His-tagged, Biotinylated HEK293 His
Mouse TGFb1-33M Active Recombinant Mouse TGF-beta 1 Protein CHO cells N/A Ala279-Ser390
Rat TGFB1-152R Recombinant Rat Tgfb1, His tagged Human Cell His
Rat Tgfb1-1384R Recombinant Rat Tgfb1 Protein, His-SUMO-tagged E.coli His/SUMO
Rat Tgfb1-531R Recombinant Rat Tgfb1 protein, His-tagged E.coli His Ala279~Ser390
Rat TGFB1-6035R Recombinant Rat TGFB1 Protein Mammalian Cell His
Rat Tgfb1-26R Recombinant Rat Tgfb1 Protein, His-tagged HEK293 His
Rat TGFB1-803RCL Recombinant Rat TGFB1 cell lysate Human Cell N/A
Rat Tgfb1-3571R Recombinant Rat Tgfb1 protein E.coli N/A 30-278aa
Rat TGFB1-5693R-B Recombinant Rat TGFB1 Protein Pre-coupled Magnetic Beads HEK293
Rat Tgfb1-3570R Recombinant Rat Tgfb1 protein, His-tagged E.coli His 30-278aa
Rat TGFB1-5693R Recombinant Rat TGFB1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Tgfb1-5071R Recombinant Rat Tgfb1 protein, His-tagged HEK293 His 30-278aa
Rabbit TGFB1-532R Recombinant Rabbit TGFB1 protein, His & T7-tagged E.coli His/T7 Phe1~Glu99 (Accession # Q4LG86)
Dog TGFB1-525D Recombinant Dog TGFB1 protein, His & GST-tagged E.coli His/GST Ala279~Ser390 (Accession # P54831)
African clawed frog TGFB1-5530A Recombinant African clawed frog TGFB1 protein, His-tagged Yeast His 271-382aa
African clawed frog tgfb1-3767A Recombinant African clawed frog tgfb1 protein, His-SUMO-tagged E.coli His-SUMO 271-382aa
Bovine Tgfb1-33B Recombinant Bovine Tgfb1 Protein, Ala279-Ser390 CHO Ala279-Ser390
Bovine TGFB1-96B Bovine Transforming Growth Factor beta-1 Reference standard N/A
Bovine TGFB1-829B Recombinant Bovine TGFB1 Protein (279-390 aa), His-tagged E.coli His 279-390 aa
Canine TGFB1-1051C Recombinant Canine TGFB1 protein, His-tagged HEK293 His Met1-Ser390
Cattle TGFB1-524C Recombinant Cattle TGFB1 protein, His & GST-tagged E.coli His/GST Ala279~Ser390 (Accession # P18341)
Cynomolgus TGFB1-028C Recombinant Cynomolgus TGFB1 Protein(Leu 30 - Ser 390 (C33S)), His-tagged HEK293 N-His Leu 30 - Ser 390 (C33S)
Cynomolgus Monkey TGFB1-1215C Active Recombinant Cynomolgus TGFB1 Protein, His-tagged HEK293 His
Guinea pig Tgfb1-527G Recombinant Guinea pig Tgfb1 protein, His & S-tagged E.coli His/S Gly279~Ser390 (Accession # Q9Z1Y6)
Horse TGFB1-1248H Recombinant Horse TGFB1 Protein, His&GST-tagged E.coli N-His&GST Ala279-Ser390
Mouse / Rat TGFB1-0758M Recombinant Mouse / Rat TGFB1 protein, Avi-tagged, Biotinylated HEK293 Avi Ala279-Ser390
Mouse, Rat TGFB1-576M Active Recombinant Mouse, Rat TGFB1 protein HEK293 N/A Ala279-Ser390
Mouse/Rat TGFB1-153R Active Recombinant Mouse/Rat TGFB1 protein HEK293 N/A Ala 279 - Ser 390
Porcine TGFB1-01P Active GMP Recombinant Porcine TGFB1 Protein, His-Tagged E.coli His
Rhesus macaque TGFB1-6544R Recombinant Rhesus macaque TGFB1 Protein(Leu30-Ser390(C33S)), His-tagged HEK293 N-His Leu30-Ser390 (C33S)
Salmo gairdneri TGFB1-5529S Recombinant Salmo gairdneri TGFB1 protein, His-tagged Yeast His 271-382aa
Sheep TGFB1-529S Recombinant Sheep TGFB1 protein, His & GST-tagged E.coli His/GST Ala279~Ser390 (Accession # P50414)
Pig TGFB1-530P Recombinant Pig TGFB1 protein, His-tagged E.coli His Ala279~Ser390 (Accession # P07200)
Pig TGFB1-199P Active Recombinant Pig TGFB1 Protein (Ala279-Ser390), C-His tagged, Animal-free, Carrier-free E.coli C-His Ala279-Ser390
Pig TGFB1-301P Recombinant Active Pig TGFB1 Protein, His-tagged(C-ter) E.coli His(C-ter)
Chicken TGFB1-526C Recombinant Chicken TGFB1 protein, His-tagged E.coli His Asp260~Ser373 (Accession # P09531)
Chicken TGFB1-3568C Recombinant Chicken TGFB1 protein, His-SUMO-tagged E.coli His-SUMO 260-373aa
  • Background
  • Quality Guarantee
  • Case Study
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource
  • Tgfb1 Related Signal Pathway
TGFB1-7.jpg

Fig1. Elucidation of the EMT mechanism in fibrosis of asthmatic airway remodeling by Cl- channel.

What is TGF-β1 protein?

TGF-β1 (transforming growth factor-beta one) protein is a secreted ligand of the TGF-β superfamily of proteins encoded by TGF-β1 gene which is situated on the long arm of chromosome 19 at locus 19q.13. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-β binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-β family members. This encoded protein regulates cell proliferation, differentiation and growth, and can modulate expression and activation of other growth factors including interferon gamma and tumor necrosis factor alpha. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease.

What is the function of TGF-β1 protein?

Bioactive TGF-β1 is involved in several biological processes associated with tumor growth and progression, such as cell differentiation, proliferation, apoptosis, and angiogenesis, and possesses an immune response suppression activity, as well as in establishing a protumoral stroma, and finally promotes cancer cell metastasis. TGF-β1 acts as a tumor suppressor in normal epithelial cells in the early stage of carcinoma by inhibiting proliferation and inducing apoptosis in premalignant epithelial cells. Within the tumor microenvironment, cancer cells may express and release TGF-β1, which influences the activities of immune cells. Also it Can induce epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. It acts as a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts.

TGF-β protein Related Pathways

TGF-β Superfamily Signaling Pathway: The signaling pathway includes a great variety of different TGF-β/BMP superfamily ligands and receptors, several types of the R-SMADs, and functionally critical negative feedback loops. TGF-β signaling is involved in the regulation of proliferation, differentiation and survival/or apoptosis of many cells, including glioma cells. TGF-β acts via specific receptors activating multiple intracellular pathways resulting in phosphorylation of receptor-regulated Smad2/3 proteins that associate with the common mediator, Smad4. TGF-β may contribute to tumor pathogenesis by direct support of tumor growth, self-renewal of glioma initiating stem cells and inhibiting of anti-tumor immunity.

P38 MAPK Signaling Pathway: p38 MAP Kinase (MAPK) participates in a signaling cascade controlling cellular responses to cytokines and stress. TGF-β1 and GPCR stimulation indirectly activate p38. p38 MAPKs regulate downstream targets including several kinases, transcription factors and cytosolic proteins.

TGF-β1 Related Diseases

The gene causing Camurati-Engelmann disease (CED) has been assigned to the chromosomal region 19q13 where the TGF-β1 gene situates. The proteins encoded by the mutated TGF-β1 alleles were characterized by impaired secretion, function or stability of the TGF-β1-LAP complex which cause Inflammatory Bowel Disease (IBD), immunodeficiency, and encephalopathy.

Biomedical Application of TGF-β1 Protein

Drug Target in Cancer Immunotherapies. Due to TGF-β1 generating a permissive and immunosuppressive the tumor microenvironment, it is an attractive target for cancer immunotherapies. For decades, a vast number of laboratories have dedicated their work to unveiling the leading cellular and molecular mechanisms involved in the TGF-β1 roles in cancer.

High Purity

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TGFB1-2.jpg

Fig2. ELISA data of TG1-HM10MB. (TGFB1-137HBS)

Case Study 1: Sheng-Lan Tian, 2018

TGFB1-3.jpg

Fig1. Protein expression levels of TGF-β1, smad2, p-smad2, smad3, and p-smad3 were evaluated with Western blot assay.

Case Study 2: Wei Yang, 2018

TGFB1-4.jpg

Fig2. Expression of TGF-β1 gene in inflammatory MAC-T cells was analyzed by RT-qPCR.

TGFB1-6.jpg

P38 MAPK Signaling Pathway

Tgfb1 involved in several pathways and played different roles in them. We selected most pathways Tgfb1 participated on our site, such as MAPK signaling pathway, Cytokine-cytokine receptor interaction, FoxO signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Tgfb1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayCACNB2;NFATC1;CACNA1SA;PDGFA;NLK2;MAPKAPK2A;PTPN7;FGFR3;CACNG6
Cytokine-cytokine receptor interactionTGFBR1A;CXCL16;CSF1;TP-1;CXCR1;IL2RB;CXCL8;ACVR1L;IL3RA
FoxO signaling pathwayMAPK12B;INSRB;KLF2A;G6PC2;PLK1;GADD45BB;CCNB2;PRKAG3;MAPK12A
Cell cycleCCNE1;ORC1;SKP1;GADD45A;CDK4;CEP72;RAD9B;TBC1D8;ACTR1A
EndocytosisEEA1;SH3GLB1A;TGFB1A;SNX5;FAM125A;VPS37B;CHMP7;HSP70;HLA-C
TGF-beta signaling pathwayNBL1;INHBC;SMURF1;RPS6KB1B;ACVR1;BMPR2A;TGFBR1;BMP7;SP1
Osteoclast differentiationPPARG;IFNAR1;RAC1;FOSL1;TYK2;MITF;IFNG;MAP2K1;FCGR3
Hippo signaling pathwayYWHAH;CRB1;BTRC;LLGL1;GDF6;WNT7A;SOX2;WNT5B;TP73
Intestinal iCD40LG;HLA-DOA;TNFSF13;CCR10;CXCL12;BMA1;CXCL12B;CXCL12A;MHC2A
ne network for IgA productionPIGR;CD40;HLA-DRB5;CCL27B;IL15RA;MADCAM1;CD40LG;Il2;CXCL12
Non-alcoholic fatty liver disease (NAFLD)NDUFB2;GSK3A;COX7B2;SREBF1;COX7A2L;NDUFB10;Casp3;NDUFB7;MLXIPL
LeishmaniasisTAB2;TNF;FOS;NFKBIB;FCGR4;HLA-DRB3;HLA-DPA1;IL4;CYBA
Chagas disease (American trypanosomiasis)CASP8;GNAL;CD247;IL12B;NOS2;MAP2K4;CCL3;BDKRB2;GNA14
MalariaTNF;PECAM1;IL1B;MET;LRP1;KLRB1;KLRC4-KLRK1;THBS1;ITGB2
ToxoplasmosisSTAT3;ITGA6;MAPK13;TRAF6;TLR4;LDLR;HLA-DQA1;HLA-DOA;HLA-DPB1
AmoebiasisRAB5B;IL1R2;GNA15;HSPB1;LAMB1;COL4A6;PIK3R1;SERPINB1A;CXCL8
TuberculosisCasp3;EP300;FCGR1A;IL10RB;IL6;CYCS;FCGR2A;LAMP2;CALM4
Hepatitis BOSTN;DDX58;PTK2B;TLR3;CREB3L3;PIK3R3;DDX3X;NFATC4;MAP3K1
HTLV-I infectionHLA-G;IKBKB;CCND3;RANBP1;HLA-B;STAT5A;CCNB2;PTTG2;FZD6
Pathways in cancerLAMB1;TGFB2;LPAR3;FGF5;SMAD3;MTOR;ITGAV;PLEKHG5;RXRA
Proteoglycans in cancerSRC;SOS1;PRKCB;MAPK13;FZD7;WNT16;PAK1;ROCK2;WNT3
Colorectal cancerBAX;SMAD4;RAC2;AKT1;RHOA;PIK3CD;CYCS;TCF7;MAP2K1
Renal cell carcinomaMAPK3;ARNT;FLCN;PIK3R3;PAK6;PIK3R5;RAPGEF1;PAK1;PAK2
Pancreatic cancerPIK3R3;MAPK3;STAT1;MAPK1;CASP9;PIK3R1;TGFB2;RAC2;SMAD4
Chronic myeloid leukemiaTP53;SMAD4;AKT2;MAPK1;GAB2;IKBKB;STAT5B;TGFB1;PIK3CB
Inflammatory bowel disease (IBD)FOXP3;HLA-DQA2;IL23R;RORC;IL21R;IL13;IFNG;HLA-DRB5;MAF
Rheumatoid arthritisTGFB1;ATP6V1E1;ICAM1;Il23a;Ctsl;ATP6V0E2;HLA-DRB4;ITGB2;ATP6V1F
Hypertrophic cardiomyopathy (HCM)SGCG;TPM2;ITGA7;CACNA2D1;ITGA8;DES;MYH7;CACNA2D4;CACNA2D2
Dilated cardiomyopathyCACNA2D2;ITGA10;ITGA5;TPM1;TNF;CACNG2;MYH7;IGF1;ITGB5

Tgfb1 has several biochemical functions, for example, antigen binding, cytokine activity, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Tgfb1 itself. We selected most functions Tgfb1 had, and list some proteins which have the same functions with Tgfb1. You can find most of the proteins on our site.

Function Related Protein
antigen bindingIL7R;PPP2R1A;TOPORS;IGHM;TSPAN4;HNRNPM;CD40;SLAMF1;SPON2
cytokine activityTNFSF11;IFNA14;MSTN;CSF1;INHBB;INHBC;WNT1;IFNA6;IFNA21
enzyme bindingTSPAN14;EGLN1;TUT1;CCDC99;HIST1H2AI;LYN;RPA3;MDM4;GOLPH3
glycoprotein bindingEDEM1;FOXRED2;SERPINA1D;ITGA3;STX1A;ITGAM;CNTN1;ACE2;BBC3
growth factor activityCSPG5;FGF6A;CXCL1;GDF1;NDR2;GDF3;GDF7;INHA;OGN
protein N-terminus bindingTRAF6;NCOA3;RPS21;PDLIM5;MAU2;KCNQ2;PARP1;NPAT;ZWINT
protein bindingMATN1;DDB2;CSK;APBB2;BCAR3;LRPAP1;GPN1;PPIB;FAM96A
protein heterodimerization activityUBA2;GRIN1;NPM1;GTF2A2;TGFB2;NEFL;HER5;ENO2;Fzd4
protein homodimerization activityFOXP2;BMPR1A;TIMM9;TIGIT;GOLGA5;ACTN1;BCL11A;PAFAH1B2;ALX1
type I transforming growth factor beta receptor bindingENG;SMAD2;FKBP1A;TGFB3;TGFBR2;SMAD6;SNX25;SMAD7;TGFB1
type II transforming growth factor beta receptor bindingTGFB1;ENG;TGFBR3;TGFB2;TGFB3;TGFBR1;BAMBI;TGFB1A
type III transforming growth factor beta receptor bindingTGFBR2;TGFB2;TGFB3;TGFB1

Tgfb1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Tgfb1 here. Most of them are supplied by our site. Hope this information will be useful for your research of Tgfb1.

TGFBR2; APP; MEOX2; 80125; FSTL1; THBS1; ENG

Gene Family

TGF

Research Area

Related articles

Mrizak, D; Martin, N; et al. Effect of Nasopharyngeal Carcinoma-Derived Exosomes on Human Regulatory T Cells. JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE 107:-(2015).
Wang, YD; Rajanbabu, V; et al. Transcriptome analysis of medaka following epinecidin-1 and TH1-5 treatment of NNV infection. FISH & SHELLFISH IMMUNOLOGY 42:121-131(2015).
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How is TGFB1 involved in bone remodeling? 08/04/2020

TGFB1 stimulates the activity of cells involved in bone formation (osteoblasts) and plays a role in regulating bone resorption by influencing osteoclast function.

Are there any side effects associated with therapies targeting TGFB1? 10/09/2019

Potential side effects of anti-TGFB1 therapies may include immune system suppression, gastrointestinal issues, and skin reactions.

Can TGFB1 be used as a biomarker for certain diseases? 04/11/2017

TGFB1 levels have been studied as potential biomarkers for diseases like cancer and fibrosis, aiding in diagnosis and monitoring disease progression.

In what ways does TGFB1 influence wound healing? 05/15/2016

TGFB1 plays a critical role in wound healing by stimulating the formation of new blood vessels, promoting the production of extracellular matrix, and aiding in the migration of cells to the wound site.

How does TGFB1 contribute to fibrosis? 05/06/2016

TGFB1 can induce the production of excessive extracellular matrix proteins, leading to tissue scarring and fibrosis in organs such as the liver, lung, and kidneys.

Customer Reviews (3)

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11/16/2021

    The impressive performance of the TGFB1 protein both in ELISA assays and protein electron microscopy structure analysis makes it a highly versatile and recommended choice for scientists across various disciplines.

    03/01/2020

      Its reliability and efficacy in generating high-quality data make it an indispensable tool in the quest for unraveling the mysteries of protein structure and function.

      07/16/2018

        The TGFB1 protein's excellent performance in ELISA ensures accurate and reproducible results, enhancing the reliability of experimental data.

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