"QPRT" Related Products

Recombinant Human Quinolinate Phosphoribosyltransferase, His-tagged

Cat. No.: QPRT-2814H
Product Overview: Recombinant human QPRT protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. MW =32.9 kDa (317aa), confirmed by MALDI-TOF.
Description: Quinolinate phosphoribosyltransferase, also known as QPRT, is a major enzyme in the catabolism of quinolinate. It is an intermediate in the tryptophannicotinamide adenine dinucleotide (NAD) pathway, leading to the production of nicotinic acid, carbon dioxide and pyrophosphate. Elevation of QPRT levels in the brain has been linked to the pathogenesis of neurodegenerative disorders such as epilepsy, Alzheimer"s disease, and Huntington"s disease.
Source: E.coli.
Sequences Of Amino Acids: MGSSHHHHHH SSGLVPRGSH MDAEGLALLL PPVTLAALVD SWLREDCPGL NYAALVSGAG PSQAALWAKS PGVLAGQPFF DAIFTQLNCQ VSWFLPEGSK LVPVARVAEV RGPAHCLLLG ERVALNTLAR CSGIASAAAA AVEAARGAGW TGHVAGTRKT TPGFRLVEKY GLLVGGAASH RYDLGGLVMV KDNHVVAAGG VEKAVRAARQ AADFALKVEV ECSSLQEAVQ AAEAGADLVL LDNFKPEELH PTATVLKAQF PSVAVEASGG ITLDNLPQFC GPHIDVISMG MLTQAAPALD FSLKLFAKEV APVPKIH
Purity: > 95% by SDS – PAGE.
Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 10% glycerol.
Concentration: 1mg/ml (determined by Bradford assay).
Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Gene Name: QPRT quinolinate phosphoribosyltransferase [ Homo sapiens ]
Synonyms: QPRT; quinolinate phosphoribosyltransferase; QPRTase; nicotinate-nucleotide pyrophosphorylase [carboxylating]; QAPRTase; nicotinate-nucleotide pyrophosphorylase (carboxylating); EC 2.4.2.19; nicotinate-nucleotide pyrophosphorylase
Gene ID: 23475
mRNA Refseq: NM_014298
Protein Refseq: NP_055113
MIM: 606248
UniProt ID: Q15274
Chromosome Location: 16p11.2
Pathway: Metabolic pathways; Nicotinate and nicotinamide metabolism
Function: nicotinate-nucleotide diphosphorylase (carboxylating) activity; nicotinate-nucleotide diphosphorylase (carboxylating) activity; protein homodimerization activity; transferase activity, transferring glycosyl groups

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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