Recombinant Human APPBP1/UBA3 Protein, His-tagged
| Cat.No. : | APPBP1/UBA3-204H |
| Product Overview : | Recombinant Human APPBP1/UBA3 protein is produced by Bacterial recombinant expression system. The UBA3 protein is fused with a His tag. |
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| Description : | APPBP1/UBA3 is the heterodimeric E1 enzyme that conjugates Nedd8 to protein substrates. Nedd8 is conjugated onto the catalytic cysteine residue of UBA3 by formation of a thioester bond in an ATP-dependent reaction. The activated Nedd8 is then passed on to an E2 (Ubc12) to be finally attached to a substrate. Nedd8 is mainly conjugated on Cullins to increase the activity of the Cullin – RING E3 Ub ligases. |
| Source : | Bacterial |
| Species : | Human |
| Tag : | His |
| Form : | 20 mM Tris, 150 mM NaCl, 2 mM βME, 10% Glycerol |
| Molecular Mass : | APPBP1 (60.2 kDa) & UBA (51.8 kDa) |
| Purity : | > 95 % by SDS-PAGE |
| Storage : | Store at -80 centigrade; avoid multiple freeze-thaw cycles. |
| Shipping : | Dry ice shipping. |
| Gene Name : | NAE1 NEDD8 activating enzyme E1 subunit 1 [ Homo sapiens (human) ] & UBA3 ubiquitin like modifier activating enzyme 3 [ Homo sapiens (human) ] |
| Official Symbol : | NAE1 & UBA3 |
| Synonyms : | APPBP1 (NAE1;HPP1; ula-1; A-116A10.1) & UBA3 (UBE1C; hUBA3; MGC22384; DKFZp566J164) |
| Gene ID : | 8883 & 9039 |
| mRNA Refseq : | NM_003905 & NM_003968 |
| Protein Refseq : | NP_003896 & NP_003959 |
| UniProt ID : | Q13564 & Q8TBC4 |
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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